5JF7
 
 | | Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor SMP289 | | Descriptor: | 2-(3-benzyl-5-bromo-1H-indol-1-yl)-N-hydroxyacetamide, ACETATE ION, IMIDAZOLE, ... | | Authors: | Fieulaine, S, Giglione, C, Meinnel, T, Hamiche, K. | | Deposit date: | 2016-04-19 | | Release date: | 2016-11-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds.
Sci Rep, 6, 2016
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5JF8
 | | Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor RAS358 (21) | | Descriptor: | ACETATE ION, IMIDAZOLE, Peptide deformylase, ... | | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | | Deposit date: | 2016-04-19 | | Release date: | 2016-11-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds.
Sci Rep, 6, 2016
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5JF0
 | | Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with tripeptide Met-Ala-Arg | | Descriptor: | ACETATE ION, MET-ALA-ARG, NICKEL (II) ION, ... | | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | | Deposit date: | 2016-04-19 | | Release date: | 2016-11-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds.
Sci Rep, 6, 2016
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3O3J
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3PN4
 | | Crystal structure of Arabidopsis thaliana petide deformylase 1B (AtPDF1B) in complex with actinonin (crystallized in PEG-550-MME) | | Descriptor: | ACTINONIN, Peptide deformylase 1B, chloroplastic, ... | | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | | Deposit date: | 2010-11-18 | | Release date: | 2011-06-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Trapping conformational States along ligand-binding dynamics of Peptide deformylase: the impact of induced fit on enzyme catalysis.
Plos Biol., 9, 2011
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3PN3
 | | Crystal structure of Arabidopsis thaliana petide deformylase 1B (AtPDF1B) in complex with inhibitor 21 | | Descriptor: | Peptide deformylase 1B, chloroplastic, ZINC ION, ... | | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | | Deposit date: | 2010-11-18 | | Release date: | 2011-06-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Trapping conformational States along ligand-binding dynamics of Peptide deformylase: the impact of induced fit on enzyme catalysis.
Plos Biol., 9, 2011
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3PN5
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4JE7
 | | Crystal structure of a human-like mitochondrial peptide deformylase in complex with actinonin | | Descriptor: | ACTINONIN, Peptide deformylase 1A, chloroplastic/mitochondrial, ... | | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | | Deposit date: | 2013-02-26 | | Release date: | 2014-02-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart.
Acta Crystallogr.,Sect.D, 70, 2014
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4JE6
 | | Crystal structure of a human-like mitochondrial peptide deformylase | | Descriptor: | Peptide deformylase 1A, chloroplastic/mitochondrial, ZINC ION | | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | | Deposit date: | 2013-02-26 | | Release date: | 2014-02-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart.
Acta Crystallogr.,Sect.D, 70, 2014
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3PN2
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4JE8
 | | Crystal structure of a human-like mitochondrial peptide deformylase in complex with Met-Ala-Ser | | Descriptor: | Peptide deformylase 1A, chloroplastic/mitochondrial, ZINC ION, ... | | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | | Deposit date: | 2013-02-26 | | Release date: | 2014-02-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart.
Acta Crystallogr.,Sect.D, 70, 2014
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3PN6
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1U2T
 | | X-Ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp. PCC6803 in complex with sucrose6P | | Descriptor: | 6-O-phosphono-beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, sucrose-phosphatase (SPP) | | Authors: | Fieulaine, S, Lunn, J.E, Borel, F, Ferrer, J.-L. | | Deposit date: | 2004-07-20 | | Release date: | 2005-06-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell
PLANT CELL, 17, 2005
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1ZXZ
 | | X-ray structure of peptide deformylase from Arabidopsis thaliana (AtPDF1A); crystals grown in PEG-5000 MME as precipitant | | Descriptor: | Peptide deformylase, mitochondrial, ZINC ION | | Authors: | Fieulaine, S, Juillan-Binard, C, Serero, A, Dardel, F, Giglione, C, Meinnel, T, Ferrer, J.-L. | | Deposit date: | 2005-06-09 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms
J.Biol.Chem., 280, 2005
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1ZY0
 | | X-ray structure of peptide deformylase from Arabidopsis thaliana (AtPDF1A); crystals grown in PEG-6000 | | Descriptor: | Peptide deformylase, mitochondrial, ZINC ION | | Authors: | Fieulaine, S, Juillan-Binard, C, Serero, A, Dardel, F, Giglione, C, Meinnel, T, Ferrer, J.-L. | | Deposit date: | 2005-06-09 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms
J.Biol.Chem., 280, 2005
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1ZY1
 | | X-ray structure of peptide deformylase from Arabidopsis thaliana (AtPDF1A) in complex with Met-Ala-Ser | | Descriptor: | Peptide deformylase, mitochondrial, ZINC ION, ... | | Authors: | Fieulaine, S, Juillan-Binard, C, Serero, A, Dardel, F, Giglione, C, Meinnel, T, Ferrer, J.-L. | | Deposit date: | 2005-06-09 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms
J.Biol.Chem., 280, 2005
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2B1Q
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2B1R
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1TJ5
 | | X-Ray structure of the Sucrose-Phosphatase (SPP) from Synechocystis sp. PCC6803 in complex with sucrose and phosphate | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, Sucrose-Phosphatase, ... | | Authors: | Fieulaine, S, Lunn, J.E, Borel, F, Ferrer, J.-L. | | Deposit date: | 2004-06-03 | | Release date: | 2005-06-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
Plant Cell, 17, 2005
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1U2S
 | | X-Ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp. PCC6803 in complex with glucose | | Descriptor: | MAGNESIUM ION, alpha-D-glucopyranose, sucrose-phosphatase | | Authors: | Fieulaine, S, Lunn, J.E, Borel, F, Ferrer, J.-L. | | Deposit date: | 2004-07-20 | | Release date: | 2005-06-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell
PLANT CELL, 17, 2005
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2D2V
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1S2O
 | | X-Ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp. PCC6803 at 1.40 A resolution | | Descriptor: | MAGNESIUM ION, sucrose-phosphatase | | Authors: | Fieulaine, S, Lunn, J.E, Borel, F, Ferrer, J.L. | | Deposit date: | 2004-01-09 | | Release date: | 2005-02-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
Plant Cell, 17, 2005
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1TJ4
 | | X-Ray structure of the Sucrose-Phosphatase (SPP) from Synechocystis sp. PCC6803 in complex with sucrose | | Descriptor: | MAGNESIUM ION, Sucrose-Phosphatase, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Fieulaine, S, Lunn, J.E, Borel, F, Ferrer, J.-L. | | Deposit date: | 2004-06-03 | | Release date: | 2005-06-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
Plant Cell, 17, 2005
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6ET4
 | | HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR | | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Hakansson, M, Walse, B, Gustavsson, A.-L, Lain, S. | | Deposit date: | 2017-10-25 | | Release date: | 2018-03-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Nat Commun, 9, 2018
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6GK0
 | | HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR | | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 4-~{tert}-butyl-~{N}-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide, ACETIC ACID, ... | | Authors: | Hakansson, M, Ladds, M.J.G.W, Walse, B, Lain, S. | | Deposit date: | 2018-05-17 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
J.Biol.Chem., 295, 2020
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