8GCM
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![BU of 8gcm by Molmil](/molmil-images/mine/8gcm) | Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein | 分子名称: | (5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. | 登録日 | 2023-03-02 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GCP
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![BU of 8gcp by Molmil](/molmil-images/mine/8gcp) | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. | 登録日 | 2023-03-02 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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6MVS
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![BU of 6mvs by Molmil](/molmil-images/mine/6mvs) | Structure of a bacterial ALDH16 complexed with NAD | 分子名称: | Aldehyde dehydrogenase, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Tanner, J.J, Liu, L. | 登録日 | 2018-10-28 | 公開日 | 2018-12-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer. J. Mol. Biol., 431, 2019
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6MVT
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![BU of 6mvt by Molmil](/molmil-images/mine/6mvt) | Structure of a bacterial ALDH16 complexed with NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Aldehyde dehydrogenase, SODIUM ION | 著者 | Tanner, J.J, Liu, L. | 登録日 | 2018-10-28 | 公開日 | 2018-12-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer. J. Mol. Biol., 431, 2019
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7TQ7
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![BU of 7tq7 by Molmil](/molmil-images/mine/7tq7) | Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 13c | 分子名称: | N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-({[(1R,2R)-2-propylcyclopropyl]methoxy}carbonyl)-L-leucinamide, Orf1a protein, TETRAETHYLENE GLYCOL | 著者 | Lovell, S, Liu, L, Battaile, K.P, Nguyen, H.N, Chamandi, S.D, Picard, H.R, Madden, T.K, Thruman, H.A, Kim, Y, Groutas, W.C, Chang, K.O. | 登録日 | 2022-01-26 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies. Acs Pharmacol Transl Sci, 6, 2023
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8W1F
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![BU of 8w1f by Molmil](/molmil-images/mine/8w1f) | Crystal Structure of DPS-like protein PA4880 from Pseudomonas aeruginosa (dodecamer, Mg bound) | 分子名称: | DPS-LIKE PROTEIN, FE (II) ION, MAGNESIUM ION, ... | 著者 | Lovell, S, Liu, L, Seibold, S, Battaile, K.P, Rivera, M. | 登録日 | 2024-02-15 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Pseudomonas aeruginosa gene PA4880 encodes a Dps-like protein with a Dps fold, bacterioferritin-type ferroxidase centers, and endonuclease activity. Front Mol Biosci, 11, 2024
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7XCT
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![BU of 7xct by Molmil](/molmil-images/mine/7xct) | Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B type 1-K, ... | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | 登録日 | 2022-03-25 | 公開日 | 2022-04-20 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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7XCR
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![BU of 7xcr by Molmil](/molmil-images/mine/7xcr) | Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | 登録日 | 2022-03-25 | 公開日 | 2022-04-20 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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7XD0
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![BU of 7xd0 by Molmil](/molmil-images/mine/7xd0) | cryo-EM structure of H2BK34ub nucleosome | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | 登録日 | 2022-03-26 | 公開日 | 2022-04-20 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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6MVR
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![BU of 6mvr by Molmil](/molmil-images/mine/6mvr) | Structure of a bacterial ALDH16 | 分子名称: | Aldehyde dehydrogenase, GLYCEROL, SULFATE ION | 著者 | Tanner, J.J, Liu, L. | 登録日 | 2018-10-28 | 公開日 | 2018-12-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer. J. Mol. Biol., 431, 2019
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5GXU
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![BU of 5gxu by Molmil](/molmil-images/mine/5gxu) | Cystal structure of Arabidopsis ATR2 | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH--cytochrome P450 reductase 2 | 著者 | Niu, G, Liu, L. | 登録日 | 2016-09-20 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function FEBS J., 284, 2017
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7YH8
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![BU of 7yh8 by Molmil](/molmil-images/mine/7yh8) | Crystal structure of a heterochiral protein complex | 分子名称: | D-Pep-1, L-19437 | 著者 | Liang, M, Li, S, Wang, T, Liu, L, Lu, P. | 登録日 | 2022-07-13 | 公開日 | 2023-07-19 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a heterochiral protein complex To Be Published
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5FEJ
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![BU of 5fej by Molmil](/molmil-images/mine/5fej) | CopM in the Cu(I)-bound form | 分子名称: | COPPER (I) ION, CopM | 著者 | Zhao, S, Wang, X, Liu, L. | 登録日 | 2015-12-17 | 公開日 | 2016-09-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM. Acta Crystallogr D Struct Biol, 72, 2016
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5FW5
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![BU of 5fw5 by Molmil](/molmil-images/mine/5fw5) | Crystal structure of human G3BP1 in complex with Semliki Forest Virus nsP3-25 comprising two FGDF motives | 分子名称: | ACETATE ION, GLYCEROL, NON-STRUCTURAL PROTEIN 3, ... | 著者 | Schulte, T, Liu, L, Panas, M.D, Thaa, B, Goette, B, Achour, A, McInerney, G.M. | 登録日 | 2016-02-12 | 公開日 | 2016-07-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication. Open Biol, 6, 2016
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5IWZ
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![BU of 5iwz by Molmil](/molmil-images/mine/5iwz) | Synaptonemal complex protein | 分子名称: | Synaptonemal complex protein 2 | 著者 | Feng, J, Fu, S, Cao, X, Wu, H, Lu, J, Zeng, M, Liu, L, Yang, X, Shen, Y. | 登録日 | 2016-03-23 | 公開日 | 2017-03-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.098 Å) | 主引用文献 | Structure of synaptonemal complexes protein at 2.6 angstroms resolution To Be Published
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4L4T
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![BU of 4l4t by Molmil](/molmil-images/mine/4l4t) | Structure of human MAIT TCR in complex with human MR1-6-FP | 分子名称: | 2-amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde, Beta-2-microglobulin, MAIT T-cell receptor alpha chain, ... | 著者 | Patel, O, Kjer-Nielsen, L, Le Nours, J, Eckle, S.B.G, Birkinshaw, R.W, Beddoe, T, Corbett, A.J, Liu, L, Miles, J.J, Meehan, B, Reantragoon, R, Sandoval-Romero, M.L, Sullivan, L.C, Brooks, A.G, Chen, Z, Fairlie, D.P, McCluskey, J, Rossjohn, J. | 登録日 | 2013-06-09 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun, 4, 2013
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8WB2
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![BU of 8wb2 by Molmil](/molmil-images/mine/8wb2) | |
5FFE
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![BU of 5ffe by Molmil](/molmil-images/mine/5ffe) | |
4L4V
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![BU of 4l4v by Molmil](/molmil-images/mine/4l4v) | Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH | 分子名称: | 1-deoxy-1-(7-hydroxy-6-methyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Patel, O, Kjer-Nielsen, L, Le Nours, J, Eckle, S.B.G, Birkinshaw, R.W, Beddoe, T, Corbett, A.J, Liu, L, Miles, J.J, Meehan, B, Reantragoon, R, Sandoval-Romero, M.L, Sullivan, L.C, Brooks, A.G, Chen, Z, Fairlie, D.P, McCluskey, J, Rossjohn, J. | 登録日 | 2013-06-09 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun, 4, 2013
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6MPW
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![BU of 6mpw by Molmil](/molmil-images/mine/6mpw) | |
7XD1
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![BU of 7xd1 by Molmil](/molmil-images/mine/7xd1) | cryo-EM structure of unmodified nucleosome | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | 登録日 | 2022-03-26 | 公開日 | 2022-04-20 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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6MQ2
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6L1G
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8W1E
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![BU of 8w1e by Molmil](/molmil-images/mine/8w1e) | Crystal Structure of DPS-like protein PA4880 from Pseudomonas aeruginosa (dodecamer) | 分子名称: | DPS-LIKE PROTEIN, FE (II) ION, SULFATE ION | 著者 | Lovell, S, Liu, L, Seibold, S, Battaile, K.P, Rivera, M. | 登録日 | 2024-02-15 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Pseudomonas aeruginosa gene PA4880 encodes a Dps-like protein with a Dps fold, bacterioferritin-type ferroxidase centers, and endonuclease activity. Front Mol Biosci, 11, 2024
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4GM3
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![BU of 4gm3 by Molmil](/molmil-images/mine/4gm3) | Crystal structure of human WD repeat domain 5 with compound MM-101 | 分子名称: | MM-101, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.393 Å) | 主引用文献 | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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