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PDB: 45 件
2WX1
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BU of 2wx1 by Molmil
TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked tri-ubiquitin, P212121
分子名称: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION
著者Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D.
登録日2009-10-30
公開日2009-11-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WWZ
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BU of 2wwz by Molmil
TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P212121
分子名称: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION
著者Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D.
登録日2009-10-30
公開日2009-11-24
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WX0
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BU of 2wx0 by Molmil
TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21
分子名称: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION
著者Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D.
登録日2009-10-30
公開日2009-11-24
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
3ZJE
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BU of 3zje by Molmil
A20 OTU domain in reversibly oxidised (SOH) state
分子名称: 1,2-ETHANEDIOL, A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJD
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BU of 3zjd by Molmil
A20 OTU domain in reduced, active state at 1.87 A resolution
分子名称: 1,2-ETHANEDIOL, A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJF
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BU of 3zjf by Molmil
A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak.
分子名称: A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJG
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BU of 3zjg by Molmil
A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak.
分子名称: CHLORIDE ION, TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
8C0D
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BU of 8c0d by Molmil
UFL1/DDRGK1 bound to UFC1
分子名称: DDRGK domain-containing protein 1, E3 UFM1-protein ligase 1, Ubiquitin-fold modifier-conjugating enzyme 1
著者Magnussen, H.M, Kulathu, Y.
登録日2022-12-16
公開日2023-12-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.564 Å)
主引用文献The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
8BZR
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BU of 8bzr by Molmil
UFC1-UFM1 conjugate
分子名称: 1,2-ETHANEDIOL, Ubiquitin-fold modifier 1, Ubiquitin-fold modifier-conjugating enzyme 1
著者Magnussen, H.M, Kulathu, Y.
登録日2022-12-15
公開日2023-12-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.781 Å)
主引用文献The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
8A67
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BU of 8a67 by Molmil
Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with matured synthetic nanobody NbSL3.3Q (3rd generation)
分子名称: CHLORIDE ION, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Lange, S.M, Kulathu, Y.
登録日2022-06-16
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Comprehensive approach to study branched ubiquitin chains reveals roles for K48-K63 branches in VCP/p97-related processes
Biorxiv, 2023
8QFD
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BU of 8qfd by Molmil
UFL1 E3 ligase bound 60S ribosome
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Makhlouf, L, Kulathu, Y, Zeqiraj, E.
登録日2023-09-04
公開日2024-02-21
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
6FGE
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BU of 6fge by Molmil
Crystal structure of human ZUFSP/ZUP1 in complex with ubiquitin
分子名称: ACETATE ION, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Kwasna, D, Abdul Rehman, S.A, Kulathu, Y.
登録日2018-01-10
公開日2018-04-04
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Mol. Cell, 70, 2018
7NPI
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BU of 7npi by Molmil
Crystal structure of Mindy2 (C266A) in complex with Lys48-linked penta-ubiquitin (K48-Ub5)
分子名称: CHLORIDE ION, Polyubiquitin-C, SODIUM ION, ...
著者Lange, S.M, Armstrong, L.A, Kulathu, Y.
登録日2021-02-26
公開日2021-09-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021
4Y1H
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BU of 4y1h by Molmil
Crystal structure of K33 linked tri-Ubiquitin
分子名称: 1,2-ETHANEDIOL, Ubiquitin-40S ribosomal protein S27a
著者Kristariyanto, Y.A, Abdul Rehman, S.A, Choi, S.Y, Ritorto, S, Campbell, D.G, Morrice, N.A, Toth, R, Kulathu, Y.
登録日2015-02-07
公開日2015-03-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem.J., 467, 2015
4XYZ
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BU of 4xyz by Molmil
Crystal structure of K33 linked di-Ubiquitin
分子名称: 1,2-ETHANEDIOL, ACETATE ION, IODIDE ION, ...
著者Kristariyanto, Y.A, Abdul Rehman, S.A, Choi, S.Y, Ritorto, S, Campbell, D.G, Morrice, N.A, Toth, R, Kulathu, Y.
登録日2015-02-03
公開日2015-03-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem.J., 467, 2015
4S1Z
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BU of 4s1z by Molmil
Crystal structure of TRABID NZF1 in complex with K29 linked di-Ubiquitin
分子名称: Ubiquitin, Ubiquitin thioesterase ZRANB1, ZINC ION
著者Kristariyanto, Y.A, Abdul Rehman, S.A, Campbell, D.G, Morrice, N.A, Johnson, C, Toth, R, Kulathu, Y.
登録日2015-01-16
公開日2015-04-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Mol.Cell, 58, 2015
4S22
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BU of 4s22 by Molmil
Crystal structure of K29 linked di-Ubiquitin
分子名称: 1,2-ETHANEDIOL, GLYCEROL, IODIDE ION, ...
著者Kristariyanto, Y.A, Abdul Rehman, S.A, Campbell, D.G, Morrice, N.A, Johnson, C, Toth, R, Kulathu, Y.
登録日2015-01-17
公開日2015-04-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Mol.Cell, 58, 2015
7NPO
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BU of 7npo by Molmil
Branched K48-K63-Ub3
分子名称: GLYCEROL, Polyubiquitin-B
著者Lange, S.M, Kwasna, D, Kulathu, Y.
登録日2021-02-27
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Branched Lys48-Lys63-linked triubiquitin
To be published
7NBB
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BU of 7nbb by Molmil
Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with synthetic nanobody NbSL3
分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ...
著者Lange, S.M, Kulathu, Y.
登録日2021-01-26
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with synthetic nanobody NbSL3
To Be Published
5JQS
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BU of 5jqs by Molmil
Crystal structure of deubiquitinase MINDY-1 in complex with Ubiquitin
分子名称: 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, Protein FAM63A, ...
著者Abdul Rehman, S.A, Kulathu, Y.
登録日2016-05-05
公開日2016-06-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Mol.Cell, 63, 2016
5JKN
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BU of 5jkn by Molmil
Crystal structure of deubiquitinase MINDY-1
分子名称: DI(HYDROXYETHYL)ETHER, MERCURY (II) ION, PHOSPHATE ION, ...
著者Abdul Rehman, S.A, Kulathu, Y.
登録日2016-04-26
公開日2016-06-22
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Mol.Cell, 63, 2016
6RUU
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BU of 6ruu by Molmil
Pseudokinase domain of human IRAK3
分子名称: GLYCEROL, Interleukin-1 receptor-associated kinase 3, MERCURY (II) ION, ...
著者Lange, S.M, Kulathu, Y, Cohen, P.
登録日2019-05-29
公開日2020-09-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.
Structure, 29, 2021
6TUV
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BU of 6tuv by Molmil
Crystal structure of Mindy1 in complex with Lys48 linked di-ubiquitin
分子名称: Polyubiquitin-C, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase MINDY-1
著者Abdul Rehman, S.A, Kulathu, Y.
登録日2020-01-08
公開日2021-01-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021
6TXB
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BU of 6txb by Molmil
Crystal structure of Mindy1 mutant (P138A) in complex with Lys48 linked di-ubiquitin
分子名称: CHLORIDE ION, Polyubiquitin-C, SODIUM ION, ...
著者Abdul Rehman, S.A, Kulathu, Y.
登録日2020-01-14
公開日2021-01-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021
6Y6R
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BU of 6y6r by Molmil
Crystal structure of MINDY1 T335D mutant
分子名称: Ubiquitin carboxyl-terminal hydrolase MINDY-1
著者Abdul Rehman, S.A, Kulathu, Y.
登録日2020-02-27
公開日2021-03-31
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021

 

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