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PDB: 25 results

7C2W
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Crystal Structure of IRAK4 kinase in complex with a small molecule inhibitor
Descriptor: Interleukin-1 receptor-associated kinase 4, N-(2-morpholin-4-yl-1,3-benzoxazol-6-yl)-6-pyridin-4-yl-pyridine-2-carboxamide
Authors:Krishnamurthy, N.R, Anirudha, L.
Deposit date:2020-05-09
Release date:2020-11-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies.
Acs Med.Chem.Lett., 11, 2020
7C2V
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Crystal Structure of IRAK4 kinase in complex with the inhibitor CA-4948
Descriptor: 2-(2-methylpyridin-4-yl)-N-[2-morpholin-4-yl-5-[(3R)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide, Interleukin-1 receptor-associated kinase 4
Authors:Krishnamurthy, N.R, Robert, B.
Deposit date:2020-05-09
Release date:2020-11-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies.
Acs Med.Chem.Lett., 11, 2020
1XFJ
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Crystal structure of protein CC_0490 from Caulobacter crescentus, Pfam DUF152
Descriptor: ACETATE ION, BETA-MERCAPTOETHANOL, GLYCEROL, ...
Authors:Krishnamurthy, N.R, Kumaran, D, Swaminathan, S, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2004-09-14
Release date:2004-09-21
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a conserved hypothetical protein from Caulobacter crescentus
To be Published
1YBF
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Crystal structure of AMP nucleosidase from Bacteroides thetaiotaomicron VPI-5482
Descriptor: AMP nucleosidase
Authors:Krishnamurthy, N.R, Swaminathan, S, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2004-12-20
Release date:2005-01-04
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of AMP nucleosidase from Bacteroides thetaiotaomicron
To be published
1ZCC
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Crystal structure of glycerophosphodiester phosphodiesterase from Agrobacterium tumefaciens str.C58
Descriptor: ACETATE ION, SULFATE ION, glycerophosphodiester phosphodiesterase
Authors:Krishnamurthy, N.R, Kumaran, D, Swaminathan, S, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2005-04-11
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of glycerophosphodiester phosphodiesterase from Agrobacterium tumefaciens by SAD with a large asymmetric unit.
Proteins, 65, 2006
1U02
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Crystal structure of trehalose-6-phosphate phosphatase related protein
Descriptor: GLYCEROL, MAGNESIUM ION, SODIUM ION, ...
Authors:Krishnamurthy, N.R, Kumaran, D, Swaminathan, S, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2004-07-12
Release date:2004-07-20
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of trehalose-6-phosphate phosphatase-related protein: biochemical and biological implications.
Protein Sci., 15, 2006
1I6F
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BU of 1i6f by Molmil
NMR SOLUTION STRUCTURE OF THE INSECT-SPECIFIC NEUROTOXIN VARIANT 5 (CSE-V5) FROM THE SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: NEUROTOXIN V-5
Authors:Jablonsky, M.J, Jackson, P.L, Krishna, N.R.
Deposit date:2001-03-02
Release date:2001-08-01
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of an insect-specific neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.
Biochemistry, 40, 2001
1I6G
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BU of 1i6g by Molmil
NMR SOLUTION STRUCTURE OF THE INSECT-SPECIFIC NEUROTOXIN VARIANT 5 (CSE-V5) FROM THE SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: NEUROTOXIN V-5
Authors:Jablonsky, M.J, Jackson, P.L, Krishna, N.R.
Deposit date:2001-03-02
Release date:2001-08-01
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:Solution structure of an insect-specific neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.
Biochemistry, 40, 2001
1B3C
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SOLUTION STRUCTURE OF A BETA-NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: PROTEIN (NEUROTOXIN CSE-I)
Authors:Jablonsky, M.J, Jackson, P.L, Trent, J.O, Watt, D.D, Krishna, N.R.
Deposit date:1998-12-08
Release date:1998-12-16
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Solution structure of a beta-neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.
Biochem.Biophys.Res.Commun., 254, 1999
1C56
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BU of 1c56 by Molmil
NMR SOLUTION STRUCTURE OF BUTANTOXIN
Descriptor: BUTANTOXIN
Authors:Holaday Jr, S.K, Martin, B.M, Fletcher Jr, P.L, Krishna, N.R.
Deposit date:1999-10-25
Release date:2000-07-19
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:NMR solution structure of butantoxin.
Arch.Biochem.Biophys., 379, 2000
1C55
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BU of 1c55 by Molmil
NMR SOLUTION STRUCTURE OF BUTANTOXIN
Descriptor: BUTANTOXIN
Authors:Holaday Jr, S.K, Martin, B.M, Fletcher Jr, P.L, Krishna, N.R.
Deposit date:1999-10-19
Release date:2000-07-19
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:NMR solution structure of butantoxin.
Arch.Biochem.Biophys., 379, 2000
2B3C
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SOLUTION STRUCTURE OF A BETA-NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: PROTEIN (NEUROTOXIN CSE-I)
Authors:Jablonsky, M.J, Jackson, P.L, Trent, J.O, Watt, D.D, Krishna, N.R.
Deposit date:1998-12-09
Release date:1998-12-16
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Solution structure of a beta-neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.
Biochem.Biophys.Res.Commun., 254, 1999
1GP8
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BU of 1gp8 by Molmil
NMR SOLUTION STRUCTURE OF THE COAT PROTEIN-BINDING DOMAIN OF BACTERIOPHAGE P22 SCAFFOLDING PROTEIN
Descriptor: PROTEIN (SCAFFOLDING PROTEIN)
Authors:Sun, Y, Parker, M.H, Weigele, P, Casjens, S, Prevelige Jr, P.E, Krishna, N.R.
Deposit date:1999-05-11
Release date:1999-05-17
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of the coat protein-binding domain of the scaffolding protein from a double-stranded DNA virus.
J.Mol.Biol., 297, 2000
1NRB
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BU of 1nrb by Molmil
SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: NEUROTOXIN V, CSE-V
Authors:Jablonsky, M.J, Krishna, N.R.
Deposit date:1995-01-03
Release date:1995-02-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of an Old World-like neurotoxin from the venom of the New World scorpion Centruroides sculpturatus Ewing.
J.Mol.Biol., 248, 1995
1NRA
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BU of 1nra by Molmil
SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: NEUROTOXIN V, CSE-V
Authors:Jablonsky, M.J, Krishna, N.R.
Deposit date:1995-01-03
Release date:1995-02-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of an Old World-like neurotoxin from the venom of the New World scorpion Centruroides sculpturatus Ewing.
J.Mol.Biol., 248, 1995
1VNA
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BU of 1vna by Molmil
PROTON NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY(SLASH)SIMULATED ANNEALING STUDIES ON THE VARIANT-1 NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: NEUROTOXIN
Authors:Lee, W, Krishna, N.R.
Deposit date:1993-10-26
Release date:1994-01-31
Last modified:2024-10-09
Method:SOLUTION NMR
Cite:Proton nuclear magnetic resonance and distance geometry/simulated annealing studies on the variant-1 neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.
Biochemistry, 33, 1994
1VNB
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BU of 1vnb by Molmil
PROTON NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY(SLASH)SIMULATED ANNEALING STUDIES ON THE VARIANT-1 NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING
Descriptor: NEUROTOXIN
Authors:Lee, W, Krishna, N.R.
Deposit date:1993-10-26
Release date:1994-01-31
Last modified:2024-10-23
Method:SOLUTION NMR
Cite:Proton nuclear magnetic resonance and distance geometry/simulated annealing studies on the variant-1 neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.
Biochemistry, 33, 1994
1NH5
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BU of 1nh5 by Molmil
AUTOMATIC ASSIGNMENT OF NMR DATA AND DETERMINATION OF THE PROTEIN STRUCTURE OF A NEW WORLD SCORPION NEUROTOXIN USING NOAH/DIAMOD
Descriptor: Neurotoxin 5
Authors:Xu, Y, Jablonsky, M.J, Jackson, P.L, Krishna, N.R, Braun, W.
Deposit date:2002-12-18
Release date:2003-01-07
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:Automatic assignment of NOESY Cross peaks and determination of the protein structure of a new world scorpion neurotoxin Using NOAH/DIAMOD
J.Magn.Reson., 148, 2001
2FQ5
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BU of 2fq5 by Molmil
NMR structure of 2F associated with lipid disc
Descriptor: Peptide 2F
Authors:Mishra, V.K, Anantharamaiah, G.M, Krishna, N.R.
Deposit date:2006-01-17
Release date:2006-01-24
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Association of a Model Class A (Apolipoprotein) Amphipathic {alpha} Helical Peptide with Lipid: High resolution NMR studies of peptide-lipid discoidal complexes
J.Biol.Chem., 281, 2006
2FQ8
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NMR structure of 2F associated with lipid disc
Descriptor: 2F
Authors:Mishra, V.K, Anantharamaiah, G.M, Krishna, N.R.
Deposit date:2006-01-17
Release date:2006-01-24
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Association of a Model Class A (Apolipoprotein) Amphipathic {alpha} Helical Peptide with Lipid: high resolution NMR studies of peptide-lipid discoidal complexes
J.Biol.Chem., 281, 2006
2GP8
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BU of 2gp8 by Molmil
NMR SOLUTION STRUCTURE OF THE COAT PROTEIN-BINDING DOMAIN OF BACTERIOPHAGE P22 SCAFFOLDING PROTEIN
Descriptor: PROTEIN (SCAFFOLDING PROTEIN)
Authors:Sun, Y, Parker, M.H, Weigele, P, Casjens, S, Prevelige Jr, P.E, Krishna, N.R.
Deposit date:1999-05-11
Release date:1999-05-17
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of the coat protein-binding domain of the scaffolding protein from a double-stranded DNA virus.
J.Mol.Biol., 297, 2000
2JYG
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BU of 2jyg by Molmil
Solution Structure of the W184A/M185A Mutant of the Carboxy-terminal Dimerization Domain of the HIV-1 Capsid Protein
Descriptor: Capsid protein p24 (CA)
Authors:Wong, H.C, Shin, R, Krishna, N.R.
Deposit date:2007-12-13
Release date:2008-02-26
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution Structure of a Double Mutant of the Carboxy-Terminal Dimerization Domain of the HIV-1 Capsid Protein.
Biochemistry, 47, 2008
2JYL
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Solution Structure of A Double Mutant of The Carboxy-terminal Dimerization Domain of The HIV-1 Capsid Protein
Descriptor: Capsid protein p24 (CA)
Authors:Wong, H.C, Shin, R, Krishna, N.R.
Deposit date:2007-12-14
Release date:2008-02-12
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution Structure of a Double Mutant of the Carboxy-Terminal Dimerization Domain of the HIV-1 Capsid Protein.
Biochemistry, 47, 2008
6INL
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Crystal structure of CDK2 IN complex with Inhibitor CVT-313
Descriptor: 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol), Cyclin-dependent kinase 2
Authors:Talapati, S.R, Krishnamurthy, N.R.
Deposit date:2018-10-25
Release date:2019-10-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313.
Acta Crystallogr.,Sect.F, 76, 2020
4JOA
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Crystal Structure of Human Anaplastic Lymphoma Kinase in complex with 7-azaindole based inhibitor
Descriptor: 3-[1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, ALK tyrosine kinase receptor
Authors:Hosahalli, S, Krishnamurthy, N.R, Lakshminarasimhan, A.
Deposit date:2013-03-18
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode
Bioorg.Med.Chem.Lett., 23, 2013

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