1ECF
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1ECG
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![BU of 1ecg by Molmil](/molmil-images/mine/1ecg) | DON INACTIVATED ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE | Descriptor: | 5-OXO-L-NORLEUCINE, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID) | Authors: | Krahn, J.M. | Deposit date: | 1996-04-23 | Release date: | 1996-11-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site. J.Biol.Chem., 271, 1996
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1ECC
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1ECB
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1MQ3
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![BU of 1mq3 by Molmil](/molmil-images/mine/1mq3) | Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine Template Paired with dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... | Authors: | Krahn, J.M, Beard, W.A, Miller, H, Grollman, A.P, Wilson, S.H. | Deposit date: | 2002-09-13 | Release date: | 2003-01-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals
Structural Insights into its Coding Potential Structure, 11, 2003
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1MQ2
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![BU of 1mq2 by Molmil](/molmil-images/mine/1mq2) | Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine and dAMP | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3', ... | Authors: | Krahn, J.M, Beard, W.A, Miller, H, Grollman, A.P, Wilson, S.H. | Deposit date: | 2002-09-13 | Release date: | 2003-01-28 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals
Structural Insights into its Coding Potential Structure, 11, 2003
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2RK1
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![BU of 2rk1 by Molmil](/molmil-images/mine/2rk1) | DHFR R67 Complexed with NADP and dihydrofolate | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, DIHYDROFOLIC ACID, Dihydrofolate reductase type 2, ... | Authors: | Krahn, J.M, London, R.E. | Deposit date: | 2007-10-16 | Release date: | 2008-06-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 46, 2007
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2RH2
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![BU of 2rh2 by Molmil](/molmil-images/mine/2rh2) | High Resolution DHFR R-67 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2 | Authors: | Krahn, J.M, London, R.E. | Deposit date: | 2007-10-05 | Release date: | 2008-06-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.96 Å) | Cite: | Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex Biochemistry, 46, 2007
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2RK2
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![BU of 2rk2 by Molmil](/molmil-images/mine/2rk2) | DHFR R-67 complexed with NADP | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Krahn, J.M, London, R.E. | Deposit date: | 2007-10-16 | Release date: | 2008-06-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 46, 2007
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1TVA
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![BU of 1tva by Molmil](/molmil-images/mine/1tva) | HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE | Descriptor: | 5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | Authors: | Krahn, J.M, Beard, W.A, Wilson, S.H. | Deposit date: | 2004-06-29 | Release date: | 2004-11-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity Structure, 12, 2004
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1TV9
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![BU of 1tv9 by Molmil](/molmil-images/mine/1tv9) | HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE | Descriptor: | 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | Authors: | Krahn, J.M, Beard, W.M, Wilson, S.H. | Deposit date: | 2004-06-29 | Release date: | 2004-11-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | STRUCTURAL INSIGHTS INTO DNA POLYMERASE BETA DETERRENTS FOR MISINCORPORATION SUPPORT OF AN INDUCED-FIT MECHANISM FOR FIDELITY Structure, 12, 2004
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3MQ1
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![BU of 3mq1 by Molmil](/molmil-images/mine/3mq1) | Crystal Structure of Dust Mite Allergen Der p 5 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Mite allergen Der p 5, ... | Authors: | Mueller, G.A, Gosavi, R.A, Krahn, J.M, Edwards, L.L, Cuneo, M.J, Glesner, J, Pomes, A, Chapman, M.D, London, R.E, Pedersen, L.C. | Deposit date: | 2010-04-27 | Release date: | 2010-06-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Der p 5 crystal structure provides insight into the group 5 dust mite allergens. J.Biol.Chem., 285, 2010
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7N06
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![BU of 7n06 by Molmil](/molmil-images/mine/7n06) | SARS-CoV-2 Nsp15 endoribonuclease post-cleavage state | Descriptor: | RNA (5'-R(*AP*UP*A)-3'), Uridylate-specific endoribonuclease | Authors: | Frazier, M.N, Dillard, L.B, Krahn, J.M, Stanley, R.E. | Deposit date: | 2021-05-25 | Release date: | 2021-06-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic Acids Res., 49, 2021
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7N33
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![BU of 7n33 by Molmil](/molmil-images/mine/7n33) | SARS-CoV-2 Nsp15 endoribonuclease pre-cleavage state | Descriptor: | RNA (5'-R(*A)-D(*(UFT))-R(P*A)-3'), Uridylate-specific endoribonuclease | Authors: | Frazier, M.N, Dillard, L.B, Krahn, J.M, Stanley, R.E. | Deposit date: | 2021-05-31 | Release date: | 2021-06-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic Acids Res., 49, 2021
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7SCD
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![BU of 7scd by Molmil](/molmil-images/mine/7scd) | Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-1 octasaccharide substrate and co-factor product PAP | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5 | Authors: | Wander, R, Kaminski, A.M, Krahn, J.M, Liu, J, Pedersen, L.C. | Deposit date: | 2021-09-27 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate Acs Catalysis, 11, 2021
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7SCE
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![BU of 7sce by Molmil](/molmil-images/mine/7sce) | Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-2 octasaccharide substrate and co-factor product PAP | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5 | Authors: | Wander, R, Kaminski, A.M, Krahn, J.M, Liu, J, Pedersen, L.C. | Deposit date: | 2021-09-27 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate Acs Catalysis, 11, 2021
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8V5D
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![BU of 8v5d by Molmil](/molmil-images/mine/8v5d) | Human mitochondrial DNA polymerase catalytic subunit, PolG, in an APO conformation | Descriptor: | DNA polymerase subunit gamma-1 | Authors: | Riccio, A.A, Brannon, A.J, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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8V54
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![BU of 8v54 by Molmil](/molmil-images/mine/8v54) | Engaged conformation of the human mitochondrial DNA polymerase gamma bound to DNA | Descriptor: | DNA (25-MER), DNA (44-MER), DNA polymerase subunit gamma-1, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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8V5R
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![BU of 8v5r by Molmil](/molmil-images/mine/8v5r) | Active conformation of DNA polymerase gamma bound to DNA | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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1ECJ
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8V55
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![BU of 8v55 by Molmil](/molmil-images/mine/8v55) | Human mitochondrial DNA polymerase gamma bound to a replication fork in an open conformation | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, M.J, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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6MAT
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![BU of 6mat by Molmil](/molmil-images/mine/6mat) | Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Rix7 mutant, unknown protein | Authors: | Lo, Y.H, Sobhany, M, Hsu, A.L, Ford, B.L, Krahn, J.M, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2018-08-28 | Release date: | 2019-02-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7. Nat Commun, 10, 2019
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6OF2
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![BU of 6of2 by Molmil](/molmil-images/mine/6of2) | Precursor ribosomal RNA processing complex, State 2. | Descriptor: | CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2019-03-28 | Release date: | 2019-09-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6OF3
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![BU of 6of3 by Molmil](/molmil-images/mine/6of3) | Precursor ribosomal RNA processing complex, State 1. | Descriptor: | CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2019-03-28 | Release date: | 2019-09-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6VCJ
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![BU of 6vcj by Molmil](/molmil-images/mine/6vcj) | Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen | Descriptor: | (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Dihydrofolate reductase, FOLIC ACID, ... | Authors: | Pedersen, L.C, London, R.E, Gabel, S.A, Krahn, J.M, DeRose, E.F. | Deposit date: | 2019-12-21 | Release date: | 2020-10-28 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J.Med.Chem., 63, 2020
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