8WGT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wgt by Molmil](/molmil-images/mine/8wgt) | Crystal structure of V30M-TTR in complex with compound 7 | 分子名称: | Transthyretin, [4,7-bis(chloranyl)-2-ethyl-1-benzofuran-3-yl]-[3,5-bis(iodanyl)-4-oxidanyl-phenyl]methanone | 著者 | Yokoyama, T. | 登録日 | 2023-09-22 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
|
|
8WGS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wgs by Molmil](/molmil-images/mine/8wgs) | Crystal structure of V30M-TTR in complex with compound 4 | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-4-iodanyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-09-22 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
|
|
8WGU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wgu by Molmil](/molmil-images/mine/8wgu) | Crystal structure of V30M-TTR in complex with compound 20 | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-[2-ethyl-4,7-bis(fluoranyl)-1-benzofuran-3-yl]methanone | 著者 | Yokoyama, T. | 登録日 | 2023-09-22 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.508 Å) | 主引用文献 | Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
|
|
6IMY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6imy by Molmil](/molmil-images/mine/6imy) | Crystal structure of V30M mutated transthyretin in complex with 4'-caroboxybenzo-18-Crown-6 | 分子名称: | 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecine-18-carboxylic acid, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J. Med. Chem., 62, 2019
|
|
6IN2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6in2 by Molmil](/molmil-images/mine/6in2) | Crystal structure of BRD1 in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ACETATE ION, Bromodomain-containing protein 1 | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor To Be Published
|
|
7FH2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fh2 by Molmil](/molmil-images/mine/7fh2) | |
4QRF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qrf by Molmil](/molmil-images/mine/4qrf) | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester | 分子名称: | 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | 登録日 | 2014-06-30 | 公開日 | 2014-11-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
|
|
8IP9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ip9 by Molmil](/molmil-images/mine/8ip9) | Wheat 40S ribosome in complex with a tRNAi | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S23, 40S ribosomal protein eS1, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
|
|
8IPA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ipa by Molmil](/molmil-images/mine/8ipa) | Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide | 分子名称: | 18S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, 40S ribosomal protein eL8, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
|
|
8IPB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ipb by Molmil](/molmil-images/mine/8ipb) | Wheat 80S ribosome pausing on AUG-Stop with cycloheximide | 分子名称: | 18S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, 40S ribosomal protein eL8, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
|
|
8IP8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ip8 by Molmil](/molmil-images/mine/8ip8) | Wheat 80S ribosome stalled on AUG-Stop boron dependently | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein eL8, 40S ribosomal protein eS1, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
|
|
8I74
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i74 by Molmil](/molmil-images/mine/8i74) | |
8I75
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i75 by Molmil](/molmil-images/mine/8i75) | |
8I76
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i76 by Molmil](/molmil-images/mine/8i76) | |
6IP6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ip6 by Molmil](/molmil-images/mine/6ip6) | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | 登録日 | 2018-11-02 | 公開日 | 2019-05-29 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
|
|
6IP8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ip8 by Molmil](/molmil-images/mine/6ip8) | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | 登録日 | 2018-11-02 | 公開日 | 2019-05-29 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
|
|
6IP5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ip5 by Molmil](/molmil-images/mine/6ip5) | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | 登録日 | 2018-11-02 | 公開日 | 2019-05-29 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
|
|
7F4Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7f4z by Molmil](/molmil-images/mine/7f4z) | X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1B, ... | 著者 | Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
|
|
7F4X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7f4x by Molmil](/molmil-images/mine/7f4x) | Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... | 著者 | Yokoyama, T, Ostermann, A, Schrader, T.E. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION | 主引用文献 | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
|
|
7F50
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7f50 by Molmil](/molmil-images/mine/7f50) | X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with AMPPnP | 分子名称: | CHLORIDE ION, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... | 著者 | Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | 主引用文献 | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
|
|
5H0Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h0z by Molmil](/molmil-images/mine/5h0z) | Crystal structure of P113A mutated human transthyretin | 分子名称: | CHLORIDE ION, SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.735 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
|
|
5H0W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h0w by Molmil](/molmil-images/mine/5h0w) | Crystal structure of H88F mutated human transthyretin | 分子名称: | SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
|
|
5H0Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h0y by Molmil](/molmil-images/mine/5h0y) | Crystal structure of H88Y mutated human transthyretin | 分子名称: | CHLORIDE ION, SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
|
|
8II1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ii1 by Molmil](/molmil-images/mine/8ii1) | Crystal structure of V30M-TTR in complex with BID | 分子名称: | Benziodarone, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.907 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
|
|
8II3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ii3 by Molmil](/molmil-images/mine/8ii3) | Crystal structure of V30M-TTR in complex with 6-hydroxy BID | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
|
|