6YXU
| Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State I, primary channel engaged | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Kouba, T, Koval, T, Krasny, L, Dohnalek, J. | 登録日 | 2020-05-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase. Nat Commun, 11, 2020
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6YYS
| Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State II, primary channel engaged and active site interfering | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Kouba, T, Koval, T, Krasny, L, Dohnalek, J. | 登録日 | 2020-05-05 | 公開日 | 2020-11-04 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase. Nat Commun, 11, 2020
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6Z11
| Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State III, primary channel dis-engaged and active site interfering | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Kouba, T, Koval, T, Krasny, L, Dohnalek, J. | 登録日 | 2020-05-11 | 公開日 | 2020-11-04 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | HelD, a helicase-like protein from gram-positive bacteria
in complex with RNA polymerase To Be Published
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6EYD
| Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Kouba, T, Barvik, I, Krasny, L. | 登録日 | 2017-11-11 | 公開日 | 2018-12-12 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.22 Å) | 主引用文献 | The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
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6F6W
| Structure of Mycobacterium smegmatis RNA polymerase core | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Kouba, T, Barvik, I, Krasny, L. | 登録日 | 2017-12-06 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
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7OE7
| Apo-structure of Lassa virus L protein (well-resolved alpha ribbon) [APO-RIBBON] | 分子名称: | MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-01 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OEA
| Lassa virus L protein bound to 3' promoter RNA (well-resolved polymerase core) [3END-CORE] | 分子名称: | 3' vRNA, MAGNESIUM ION, RNA-directed RNA polymerase L, ... | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-02 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OE3
| Apo-structure of Lassa virus L protein (well-resolved endonuclease) [APO-ENDO] | 分子名称: | MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-01 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OEB
| Lassa virus L protein bound to 3' promoter RNA (well-resolved endonuclease) [3END-ENDO] | 分子名称: | 3' vRNA, MAGNESIUM ION, RNA-directed RNA polymerase L, ... | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-02 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OCH
| Apo-structure of Lassa virus L protein (well-resolved polymerase core) [APO-CORE] | 分子名称: | MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-04-26 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OJK
| Lassa virus L protein bound to the distal promoter duplex [DISTAL-PROMOTER] | 分子名称: | 3' RNA, 5' RNA, RNA-directed RNA polymerase L, ... | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-16 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OJN
| Lassa virus L protein in an elongation conformation [ELONGATION] | 分子名称: | 3' RNA, 5' RNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-16 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OJJ
| Lassa virus L protein with endonuclease and C-terminal domains in close proximity [MID-LINK] | 分子名称: | MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-16 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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7OJL
| Lassa virus L protein in a pre-initiation conformation [PREINITIATION] | 分子名称: | 3' RNA, 5' RNA, MANGANESE (II) ION, ... | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | 登録日 | 2021-05-16 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
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8R6P
| Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA, HelD N-terminal domain and open promoter DNA | 分子名称: | DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | 登録日 | 2023-11-22 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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8R6R
| Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA and open promoter DNA | 分子名称: | DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | 登録日 | 2023-11-22 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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6Y6K
| Cryo-EM structure of a Phenuiviridae L protein | 分子名称: | MAGNESIUM ION, RNA-dependent RNA polymerase | 著者 | Vogel, D, Thorkelsson, S.R, Quemin, E, Meier, K, Kouba, T, Gogrefe, N, Busch, C, Reindl, S, Guenther, S, Cusack, S, Gruenewald, K, Rosenthal, M. | 登録日 | 2020-02-26 | 公開日 | 2020-04-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 48, 2020
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6QCS
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6QCT
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8CBQ
| structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | 登録日 | 2023-01-25 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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8CBN
| structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | 登録日 | 2023-01-25 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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5NP0
| Closed dimer of human ATM (Ataxia telangiectasia mutated) | 分子名称: | Serine-protein kinase ATM | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | 登録日 | 2017-04-13 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
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5NP1
| Open protomer of human ATM (Ataxia telangiectasia mutated) | 分子名称: | Serine-protein kinase ATM | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | 登録日 | 2017-04-13 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
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7R0E
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7QTL
| Influenza A/H7N9 polymerase elongation complex | 分子名称: | 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... | 著者 | Cusack, S, Kouba, T. | 登録日 | 2022-01-14 | 公開日 | 2022-12-28 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
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