5DRB
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![BU of 5drb by Molmil](/molmil-images/mine/5drb) | Crystal structure of WNK1 in complex with WNK463 | Descriptor: | N-tert-butyl-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl}piperidin-4-yl)-1H-imidazole-5-carboxamide, Serine/threonine-protein kinase WNK1 | Authors: | Kohls, D, Xie, X. | Deposit date: | 2015-09-15 | Release date: | 2016-09-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat.Chem.Biol., 12, 2016
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1QD1
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![BU of 1qd1 by Molmil](/molmil-images/mine/1qd1) | THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE. | Descriptor: | FORMIMINOTRANSFERASE-CYCLODEAMINASE, GLYCEROL, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid | Authors: | Kohls, D, Sulea, T, Purisima, E, MacKenzie, R.E, Vrielink, A. | Deposit date: | 1999-07-08 | Release date: | 2000-01-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme. Structure Fold.Des., 8, 2000
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5WE8
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![BU of 5we8 by Molmil](/molmil-images/mine/5we8) | |
5WDY
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![BU of 5wdy by Molmil](/molmil-images/mine/5wdy) | |
1Z1L
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![BU of 1z1l by Molmil](/molmil-images/mine/1z1l) | The Crystal Structure of the Phosphodiesterase 2A Catalytic Domain | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, ZINC ION, ... | Authors: | Ding, Y.H, Kohls, D, Low, C. | Deposit date: | 2005-03-04 | Release date: | 2005-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Determinants for Inhibitor Specificity and Selectivity in PDE2A Using the Wheat Germ in Vitro Translation System. Biochemistry, 44, 2005
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2RKU
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![BU of 2rku by Molmil](/molmil-images/mine/2rku) | Structure of PLK1 in complex with BI2536 | Descriptor: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, D(-)-TARTARIC ACID, L(+)-TARTARIC ACID, ... | Authors: | Ding, Y.-H, Kothe, M, Kohls, D, Low, S. | Deposit date: | 2007-10-17 | Release date: | 2008-02-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Selectivity-determining residues in Plk1. Chem.Biol.Drug Des., 70, 2007
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2OU7
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![BU of 2ou7 by Molmil](/molmil-images/mine/2ou7) | Structure of the Catalytic Domain of Human Polo-like Kinase 1 | Descriptor: | ACETATE ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Ding, Y.-H, Kothe, M, Kohls, D, Low, S. | Deposit date: | 2007-02-09 | Release date: | 2007-04-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the catalytic domain of human polo-like kinase 1. Biochemistry, 46, 2007
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2OWB
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![BU of 2owb by Molmil](/molmil-images/mine/2owb) | Structure of the Catalytic Domain of Human Polo-like Kinase 1 | Descriptor: | 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ACETATE ION, Serine/threonine-protein kinase PLK1, ... | Authors: | Ding, Y.-H, Kothe, M, Kohls, D, Low, S. | Deposit date: | 2007-02-15 | Release date: | 2007-04-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the catalytic domain of human polo-like kinase 1. Biochemistry, 46, 2007
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3RWQ
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![BU of 3rwq by Molmil](/molmil-images/mine/3rwq) | Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1) | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... | Authors: | Kazmirski, S, Kohls, D. | Deposit date: | 2011-05-09 | Release date: | 2011-11-16 | Last modified: | 2011-12-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1). J.Med.Chem., 54, 2011
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