Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5WDY

Crystal structure of WNK1 in complex with 1-cyclohexyl-N-({6-fluoro-1-[2-(3-methoxyphenyl)pyridin-4-yl]-1H-indol-3-yl}methyl)methanamine (compound 6)

Summary for 5WDY
Entry DOI10.2210/pdb5wdy/pdb
DescriptorSerine/threonine-protein kinase WNK1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1-cyclohexyl-N-({6-fluoro-1-[2-(3-methoxyphenyl)pyridin-4-yl]-1H-indol-3-yl}methyl)methanamine, ... (5 entities in total)
Functional Keywordskinase, inhibitor, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : Q9H4A3
Total number of polymer chains2
Total formula weight65852.14
Authors
Xie, X.,Kohls, D. (deposition date: 2017-07-06, release date: 2017-08-16, Last modification date: 2024-03-13)
Primary citationYamada, K.,Levell, J.,Yoon, T.,Kohls, D.,Yowe, D.,Rigel, D.F.,Imase, H.,Yuan, J.,Yasoshima, K.,DiPetrillo, K.,Monovich, L.,Xu, L.,Zhu, M.,Kato, M.,Jain, M.,Idamakanti, N.,Taslimi, P.,Kawanami, T.,Argikar, U.A.,Kunjathoor, V.,Xie, X.,Yagi, Y.I.,Iwaki, Y.,Robinson, Z.,Park, H.M.
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
J. Med. Chem., 60:7099-7107, 2017
Cited by
PubMed: 28771350
DOI: 10.1021/acs.jmedchem.7b00708
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.458 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon