8QMH
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![BU of 8qmh by Molmil](/molmil-images/mine/8qmh) | Crystal structure of RNA G2C4 repeats in complex with small synthetic molecule ANP77 | Descriptor: | 3-(7-azanyl-1,8-naphthyridin-2-yl)-2-[(7-azanyl-1,8-naphthyridin-2-yl)methyl]-~{N}-(3-azanylpropyl)propanamide, CHLORIDE ION, RNA (5'-R(*GP*GP*CP*CP*CP*C)-3') | Authors: | Kiliszek, A, Ryczek, M, Blaszczyk, L. | Deposit date: | 2023-09-22 | Release date: | 2024-05-01 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand. Nucleic Acids Res., 52, 2024
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5MWI
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![BU of 5mwi by Molmil](/molmil-images/mine/5mwi) | |
4XW0
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3GLP
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![BU of 3glp by Molmil](/molmil-images/mine/3glp) | 1.23 A resolution X-ray structure of (GCUGCUGC)2 | Descriptor: | 5'-R(*GP*CP*UP*GP*CP*UP*GP*C)-3', GLYCEROL, SULFATE ION | Authors: | Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, W. | Deposit date: | 2009-03-12 | Release date: | 2009-05-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy. Nucleic Acids Res., 37, 2009
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3GM7
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![BU of 3gm7 by Molmil](/molmil-images/mine/3gm7) | |
3NJ7
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![BU of 3nj7 by Molmil](/molmil-images/mine/3nj7) | 1.9 A resolution X-ray structure of (GGCAGCAGCC)2 | Descriptor: | 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3', SULFATE ION | Authors: | Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, W. | Deposit date: | 2010-06-17 | Release date: | 2010-08-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.904 Å) | Cite: | Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases. Nucleic Acids Res., 38, 2010
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4XW1
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3NJ6
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![BU of 3nj6 by Molmil](/molmil-images/mine/3nj6) | 0.95 A resolution X-ray structure of (GGCAGCAGCC)2 | Descriptor: | 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3', SULFATE ION | Authors: | Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, W. | Deposit date: | 2010-06-17 | Release date: | 2010-08-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases. Nucleic Acids Res., 38, 2010
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5EMG
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![BU of 5emg by Molmil](/molmil-images/mine/5emg) | Crystal structures of PNA p(GCTGCTGC)2 duplex containing T-T mismatches | Descriptor: | CHLORIDE ION, GPN-CPN-TPN-GPN-CPN-TPN-GPN-CPN, SODIUM ION | Authors: | Kiliszek, A, Banaszak, K, Dauter, Z, Rypniewski, W. | Deposit date: | 2015-11-06 | Release date: | 2016-01-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs. Nucleic Acids Res., 44, 2016
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4E59
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5EMF
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![BU of 5emf by Molmil](/molmil-images/mine/5emf) | Crystal structure of RNA r(GCUGCUGC) with antisense PNA p(GCAGCAGC) | Descriptor: | CHLORIDE ION, RNA (5'-R(*GP*CP*UP*GP*CP*UP*GP*C)-3'), antisense PNA p(GCAGCAGC) | Authors: | Kiliszek, A, Banaszak, K, Dauter, Z, Rypniewski, W. | Deposit date: | 2015-11-06 | Release date: | 2016-01-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs. Nucleic Acids Res., 44, 2016
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4E58
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![BU of 4e58 by Molmil](/molmil-images/mine/4e58) | Crystal structure of GCC(LCG)CCGC duplex containing LNA residue | Descriptor: | RNA duplex containing CCG repeats, SULFATE ION | Authors: | Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, R. | Deposit date: | 2012-03-14 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Crystallographic characterization of CCG repeats. Nucleic Acids Res., 40, 2012
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6QIS
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![BU of 6qis by Molmil](/molmil-images/mine/6qis) | Crystal structure of CAG repeats with synthetic CMBL3a compound (model II) | Descriptor: | CMBL3a, RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3'), SULFATE ION | Authors: | Kiliszek, A, Blaszczyk, L, Rypniewski, W, Nakatani, K. | Deposit date: | 2019-01-21 | Release date: | 2019-09-25 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res., 47, 2019
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6QIQ
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![BU of 6qiq by Molmil](/molmil-images/mine/6qiq) | Crystal structure of seleno-derivative CAG repeats with synthetic CMBL3a compound | Descriptor: | CMBL3a, RNA (5'-R(*GP*CP*AP*G)-D(P*(CSL))-R(P*AP*GP*C)-3') | Authors: | Kiliszek, A, Blaszczyk, L, Rypniewski, W, Micura, R, Nakatani, K. | Deposit date: | 2019-01-21 | Release date: | 2019-09-25 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.519 Å) | Cite: | Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res., 47, 2019
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6QIT
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![BU of 6qit by Molmil](/molmil-images/mine/6qit) | Crystal structure of CAG repeats with synthetic CMBL3b compound | Descriptor: | CMBL3a, RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3') | Authors: | Kiliszek, A, Blaszczyk, L, Rypniewski, W, Nakatani, K. | Deposit date: | 2019-01-21 | Release date: | 2019-09-25 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res., 47, 2019
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5EME
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![BU of 5eme by Molmil](/molmil-images/mine/5eme) | Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC) | Descriptor: | Antisense PNA strand, CHLORIDE ION, RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3') | Authors: | Kiliszek, A, Banaszak, K, Dauter, Z, Rypniewski, W. | Deposit date: | 2015-11-06 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs. Nucleic Acids Res., 44, 2016
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6QIV
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![BU of 6qiv by Molmil](/molmil-images/mine/6qiv) | Crystal structure of seleno-derivative CAG repeats with synthetic CMBL4 compound | Descriptor: | CMBL4, RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3') | Authors: | Kiliszek, A, Blaszczyk, L, Rypniewski, W, Nakatani, K. | Deposit date: | 2019-01-21 | Release date: | 2019-09-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res., 47, 2019
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6QIR
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![BU of 6qir by Molmil](/molmil-images/mine/6qir) | Crystal structure of CAG repeats with synthetic CMBL3a compound (model I) | Descriptor: | CMBL3a, RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3') | Authors: | Kiliszek, A, Blaszczyk, L, Rypniewski, W, Nakatani, K. | Deposit date: | 2019-01-21 | Release date: | 2019-09-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.531 Å) | Cite: | Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res., 47, 2019
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3R1C
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![BU of 3r1c by Molmil](/molmil-images/mine/3r1c) | Crystal structure of GCGGCGGC duplex | Descriptor: | RNA (5'-R(*GP*CP*GP*GP*CP*GP*GP*C)-3'), SULFATE ION | Authors: | Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, W. | Deposit date: | 2011-03-10 | Release date: | 2011-06-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.0531 Å) | Cite: | Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome. Nucleic Acids Res., 39, 2011
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3R1D
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![BU of 3r1d by Molmil](/molmil-images/mine/3r1d) | Crystal structure of GC(8BrG)GCGGCGGC duplex | Descriptor: | BROMIDE ION, RNA (5'-R(*GP*CP*(GRB)P*GP*CP*GP*GP*CP*GP*GP*C)-3'), SULFATE ION | Authors: | Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, W. | Deposit date: | 2011-03-10 | Release date: | 2011-06-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome. Nucleic Acids Res., 39, 2011
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3R1E
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![BU of 3r1e by Molmil](/molmil-images/mine/3r1e) | Crystal structure of GC(8BrG)GCGGC duplex | Descriptor: | BROMIDE ION, CALCIUM ION, GLYCEROL, ... | Authors: | Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, W. | Deposit date: | 2011-03-10 | Release date: | 2011-06-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (0.972 Å) | Cite: | Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome. Nucleic Acids Res., 39, 2011
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6HNU
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![BU of 6hnu by Molmil](/molmil-images/mine/6hnu) | Crystal structure of the aminotransferase Aro8 from C. Albicans with ligands | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aromatic amino acid aminotransferase I, ... | Authors: | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | Deposit date: | 2018-09-17 | Release date: | 2019-02-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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6HNV
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![BU of 6hnv by Molmil](/molmil-images/mine/6hnv) | Crystal structure of aminotransferase Aro9 from C. Albicans with ligands | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINOHEXANEDIOIC ACID, 2-OXOADIPIC ACID, ... | Authors: | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | Deposit date: | 2018-09-17 | Release date: | 2019-02-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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6HNB
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![BU of 6hnb by Molmil](/molmil-images/mine/6hnb) | Crystal structure of aminotransferase Aro8 from Candida albicans | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aromatic amino acid aminotransferase I, CHLORIDE ION, ... | Authors: | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | Deposit date: | 2018-09-14 | Release date: | 2019-02-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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8AMG
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![BU of 8amg by Molmil](/molmil-images/mine/8amg) | Crystal structure of AUGUGGCAU duplex with barium ions (model 1) | Descriptor: | BARIUM ION, RNA (5'-R(*AP*UP*GP*UP*GP*GP*CP*AP*U)-3') | Authors: | Kiliszek, A, Rypniewski, W. | Deposit date: | 2022-08-03 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structure and thermodynamics of a UGG motif interacting with Ba2+ and other metal ions: accommodating changes in the RNA structure and the presence of a G(syn)-G(syn) pair. Rna, 29, 2022
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