8D97
| Apo gRAMP | Descriptor: | RAMP superfamily protein, RNA (42-MER), ZINC ION | Authors: | Hu, C, Nam, K.H, Schuler, G, Ke, A. | Deposit date: | 2022-06-09 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377, 2022
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8CTL
| IscB and wRNA bound to Target DNA (locked state) | Descriptor: | DNA non-target strand, DNA target strand, IscB, ... | Authors: | Schuler, G.A, Hu, C, Ke, A. | Deposit date: | 2022-05-16 | Release date: | 2022-06-15 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for RNA-guided DNA cleavage by IscB-omega RNA and mechanistic comparison with Cas9. Science, 376, 2022
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8D9H
| gRAMP-TPR-CHAT match PFS target RNA(Craspase) | Descriptor: | CHAT domain protein, PHOSPHATE ION, RAMP superfamily protein, ... | Authors: | Hu, C, Nam, K.H, Schuler, G, Ke, A. | Deposit date: | 2022-06-09 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377, 2022
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8D9E
| gRAMP-match PFS target | Descriptor: | RAMP superfamily protein, RNA (36-MER), RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*GP*UP*A)-3'), ... | Authors: | Hu, C, Nam, K.H, Schuler, G, Ke, A. | Deposit date: | 2022-06-09 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377, 2022
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8D9F
| gRAMP-TPR-CHAT (Craspase) | Descriptor: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | Authors: | Hu, C, Nam, K.H, Schuler, G, Ke, A. | Deposit date: | 2022-06-09 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377, 2022
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8D9I
| gRAMP non-matching PFS-with Mg | Descriptor: | RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*A)-3'), ... | Authors: | Hu, C, Nam, K.H, Schuler, G, Ke, A. | Deposit date: | 2022-06-09 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377, 2022
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8D9G
| gRAMP-TPR-CHAT Non match PFS target RNA(Craspase) | Descriptor: | CHAT domain protein, RAMP superfamily protein, RNA (36-MER), ... | Authors: | Hu, C, Nam, K.H, Schuler, G, Ke, A. | Deposit date: | 2022-06-09 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377, 2022
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8D8N
| gRAMP non-match PFS target RNA | Descriptor: | RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*AP*CP*A)-3'), ... | Authors: | Hu, C, Nam, K.H, Schuler, G, Ke, A. | Deposit date: | 2022-06-08 | Release date: | 2022-08-31 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377, 2022
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8CSZ
| IscB and wRNA bound to Target DNA | Descriptor: | DNA non-target strand, DNA target strand, IscB, ... | Authors: | Schuler, G.A, Hu, C, Ke, A. | Deposit date: | 2022-05-13 | Release date: | 2022-06-15 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for RNA-guided DNA cleavage by IscB-omega RNA and mechanistic comparison with Cas9. Science, 376, 2022
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4Y1I
| Lactococcus lactis yybP-ykoY Mn riboswitch bound to Mn2+ | Descriptor: | BARIUM ION, GUANOSINE-5'-TRIPHOSPHATE, Lactococcus lactis yybP-ykoY riboswitch, ... | Authors: | Price, I.R, Ke, A. | Deposit date: | 2015-02-07 | Release date: | 2015-04-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Mn(2+)-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches. Mol.Cell, 57, 2015
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4Y1J
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6C27
| SAM-III riboswitch ON-state | Descriptor: | COBALT HEXAMMINE(III), SAM-III riboswitch | Authors: | Grigg, J.C, Price, I.R, Ke, A. | Deposit date: | 2018-01-07 | Release date: | 2019-01-09 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (3.601 Å) | Cite: | Evidence for two-tiered conformation selection in the SAM-III riboswitch To Be Published
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2XXA
| The Crystal Structure of the Signal Recognition Particle (SRP) in Complex with its Receptor(SR) | Descriptor: | 4.5S RNA, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Ataide, S.F, Schmitz, N, Shen, K, Ke, A, Shan, S, Doudna, J.A, Ban, N. | Deposit date: | 2010-11-09 | Release date: | 2011-03-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.94 Å) | Cite: | The Crystal Structure of the Signal Recognition Particle in Complex with its Receptor. Science, 331, 2011
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4Y1M
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6UFG
| Co-crystal structure of M. tuberculosis ileS T-box in complex with tRNA-3'-OH | Descriptor: | MAGNESIUM ION, POTASSIUM ION, RNA (166-MER), ... | Authors: | Battaglia, R.A, Grigg, J.C, Ke, A. | Deposit date: | 2019-09-24 | Release date: | 2019-11-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.929 Å) | Cite: | Structural basis for tRNA decoding and aminoacylation sensing by T-box riboregulators. Nat.Struct.Mol.Biol., 26, 2019
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6UFH
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3R4F
| Prohead RNA | Descriptor: | MAGNESIUM ION, pRNA | Authors: | Ding, F, Lu, C, Zhano, W, Rajashankar, K.R, Anderson, D.L, Jardine, P.J, Grimes, S, Ke, A. | Deposit date: | 2011-03-17 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure and assembly of the essential RNA ring component of a viral DNA packaging motor. Proc.Natl.Acad.Sci.USA, 108, 2011
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7TRA
| Cascade complex from type I-A CRISPR-Cas system | Descriptor: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | Authors: | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | Deposit date: | 2022-01-28 | Release date: | 2022-08-10 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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7TR9
| Cascade complex from type I-A CRISPR-Cas system | Descriptor: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | Authors: | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | Deposit date: | 2022-01-28 | Release date: | 2022-08-10 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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7TR8
| Cascade complex from type I-A CRISPR-Cas system | Descriptor: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | Authors: | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | Deposit date: | 2022-01-28 | Release date: | 2022-08-10 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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7TR6
| Cascade complex from type I-A CRISPR-Cas system | Descriptor: | Cas11a, Cas5a, Cas7a, ... | Authors: | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | Deposit date: | 2022-01-28 | Release date: | 2022-08-10 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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7R2K
| elongated Cascade complex from type I-A CRISPR-Cas system | Descriptor: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | Authors: | Hu, C, Ni, D, Nam, K.H, Terns, M, Stahlberg, H, Ke, A. | Deposit date: | 2022-02-04 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural snapshots for an atypic type I CRISPR-Cas system To Be Published
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7R21
| elongated Cascade complex from type I-A CRISPR-Cas system | Descriptor: | Cas11a, Cas7a, CrRNA (62-MER), ... | Authors: | Hu, C, Ni, D, Nam, K.H, Stahlberg, H, Terns, M, Ke, A. | Deposit date: | 2022-02-04 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural snapshots for an atypic type I CRISPR-Cas system To Be Published
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7MI5
| Asymmetrical PAM-Non PAM prespacer bound Cas4/Cas1/Cas2 complex | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (26-MER), ... | Authors: | Hu, C.Y, Ke, A.K. | Deposit date: | 2021-04-16 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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7MI4
| Symmetrical PAM-PAM prespacer bound Cas4/Cas1/Cas2 complex | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (35-MER), ... | Authors: | Hu, C.Y, Ke, A.K. | Deposit date: | 2021-04-16 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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