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PDB: 20 件
4ZIR
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BU of 4zir by Molmil
Crystal structure of EcfAA' heterodimer bound to AMPPNP
分子名称: CHLORIDE ION, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ...
著者Karpowich, N.K, Cocco, N, Song, J.M, Wang, D.N.
登録日2015-04-28
公開日2015-06-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism.
Nat.Struct.Mol.Biol., 22, 2015
1N4A
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BU of 1n4a by Molmil
The Ligand Bound Structure of E.coli BtuF, the Periplasmic Binding Protein for Vitamin B12
分子名称: CYANOCOBALAMIN, Vitamin B12 transport protein btuF
著者Karpowich, N.K, Smith, P.C, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2002-10-30
公開日2003-03-11
最終更新日2021-08-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in protein mobility upon ligand binding.
J.Biol.Chem., 278, 2003
5KBW
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BU of 5kbw by Molmil
Crystal structure of TmRibU, the riboflavin-binding S subunit from the Thermotoga maritima ECF transporter
分子名称: RIBOFLAVIN, Riboflavin transporter RibU
著者Karpowich, N.K, Wang, D.N, Song, J.M.
登録日2016-06-03
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6093 Å)
主引用文献An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin.
J.Mol.Biol., 428, 2016
5KC4
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BU of 5kc4 by Molmil
Structure of TmRibU, orthorhombic crystal form
分子名称: RIBOFLAVIN, Riboflavin transporter RibU, nonyl beta-D-glucopyranoside
著者Karpowich, N.K, Wang, D.N, Song, J.M.
登録日2016-06-04
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin.
J.Mol.Biol., 428, 2016
5KC0
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BU of 5kc0 by Molmil
Crystal structure of TmRibU, hexagonal crystal form
分子名称: RIBOFLAVIN, Riboflavin transporter RibU, nonyl beta-D-glucopyranoside
著者Karpowich, N.K, Wang, D.N, Song, J.M.
登録日2016-06-03
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2001 Å)
主引用文献An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin.
J.Mol.Biol., 428, 2016
2QJU
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BU of 2qju by Molmil
Crystal Structure of an NSS Homolog with Bound Antidepressant
分子名称: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, LEUCINE, ...
著者Zhou, Z, Karpowich, N.K, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS)
登録日2007-07-09
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science, 317, 2007
4HLU
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BU of 4hlu by Molmil
Structure of the EcfA-A' heterodimer bound to ADP
分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Energy-coupling factor transporter ATP-binding protein EcfA, ...
著者Wang, D.N, Karpowich, N.K.
登録日2012-10-17
公開日2013-02-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7003 Å)
主引用文献Assembly and mechanism of a group II ECF transporter.
Proc.Natl.Acad.Sci.USA, 110, 2013
8SE6
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BU of 8se6 by Molmil
NKG2D complexed with inhibitor 36
分子名称: N-[(1S)-2-(dimethylamino)-2-oxo-1-{3-[3-(2,2,2-trifluoroethyl)azetidin-1-yl]phenyl}ethyl]-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein, TETRAETHYLENE GLYCOL, ...
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2023-04-08
公開日2023-10-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Bioorg.Med.Chem.Lett., 96, 2023
8SE5
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BU of 8se5 by Molmil
NKG2D complexed with inhibitor 14
分子名称: DI(HYDROXYETHYL)ETHER, N-{(1S)-2-[(1R,5S,6S)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein, ...
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2023-04-08
公開日2023-10-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Bioorg.Med.Chem.Lett., 96, 2023
3GWU
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BU of 3gwu by Molmil
Leucine transporter LeuT in complex with sertraline
分子名称: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ...
著者Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
登録日2009-04-01
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWV
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BU of 3gwv by Molmil
Leucine transporter LeuT in complex with R-fluoxetine
分子名称: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ...
著者Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
登録日2009-04-01
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWW
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BU of 3gww by Molmil
Leucine transporter LeuT in complex with S-fluoxetine
分子名称: (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ...
著者Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
登録日2009-04-01
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
8EA8
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BU of 8ea8 by Molmil
NKG2D complexed with inhibitor 4a
分子名称: DI(HYDROXYETHYL)ETHER, N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ...
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2022-08-28
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA7
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BU of 8ea7 by Molmil
NKG2D complexed with inhibitor 3g
分子名称: (4M)-N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-(1-methyl-1H-pyrazol-5-yl)-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, DI(HYDROXYETHYL)ETHER, NKG2-D type II integral membrane protein
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2022-08-28
公開日2023-05-03
最終更新日2023-05-10
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA5
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BU of 8ea5 by Molmil
NKG2D complexed with inhibitor 1a
分子名称: (3S,5aS,8aR)-3-benzyl-6-[(3,5-dichlorophenyl)methyl]-1,4-dimethyloctahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione, NKG2-D type II integral membrane protein, TRIETHYLENE GLYCOL
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2022-08-28
公開日2023-05-03
最終更新日2023-05-10
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA9
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BU of 8ea9 by Molmil
NKG2D complexed with inhibitor 4d
分子名称: DI(HYDROXYETHYL)ETHER, N-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-(dimethylamino)-2-oxoethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ...
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2022-08-28
公開日2023-05-03
最終更新日2023-05-10
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EAB
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BU of 8eab by Molmil
NKG2D complexed with inhibitor 4f
分子名称: DI(HYDROXYETHYL)ETHER, N-[(1S)-2-oxo-1-[3-(trifluoromethyl)phenyl]-2-({4-[4-(trifluoromethyl)phenyl]pyridin-3-yl}amino)ethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2022-08-28
公開日2023-05-03
最終更新日2023-05-10
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA6
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NKG2D complexed with inhibitor 3e
分子名称: N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2022-08-28
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EAA
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BU of 8eaa by Molmil
NKG2D complexed with inhibitor 4e
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, N-{(1S)-2-(dimethylamino)-1-[3-methyl-5-(trifluoromethyl)phenyl]-2-oxoethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, ...
著者Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
登録日2022-08-28
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
2H28
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BU of 2h28 by Molmil
Crystal structure of YeeU from E. coli. Northeast Structural Genomics target ER304
分子名称: CHLORIDE ION, GLYCEROL, Hypothetical protein yeeU, ...
著者Arbing, M, Su, M, Benach, J, Karpowich, N.K, Jiang, M, Xiao, R, Cunningham, K, Ma, L.-C, Chen, C.X, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2006-05-18
公開日2006-07-18
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems.
Structure, 18, 2010

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