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PDB: 57 件
5W0G
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BU of 5w0g by Molmil
Structure of U2AF65 (U2AF2) RRM1 at 1.07 resolution
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, Splicing factor U2AF 65 kDa subunit, ...
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2017-05-30
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.
Biochemistry, 56, 2017
5W0H
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Structure of U2AF65 (U2AF2) RRM2 at 1.11 Angstrom Resolution
分子名称: Splicing factor U2AF 65 kDa subunit
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2017-05-30
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.11 Å)
主引用文献Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.
Biochemistry, 56, 2017
6XLX
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BU of 6xlx by Molmil
Crystal structure of cancer-associated G301D mutant of U2AF65 bound to AdML splice site
分子名称: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
著者Maji, D, Jenkins, J.L, Kielkopf, C.L.
登録日2020-06-29
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
6XLV
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BU of 6xlv by Molmil
Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site
分子名称: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
著者Maji, D, Jenkins, J.L, Kielkopf, C.L.
登録日2020-06-29
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
3BS9
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BU of 3bs9 by Molmil
X-ray structure of human TIA-1 RRM2
分子名称: IODIDE ION, Nucleolysin TIA-1 isoform p40
著者Kumar, A.O, Kielkopf, C.L.
登録日2007-12-22
公開日2008-01-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.
Biochem.Biophys.Res.Commun., 367, 2008
5EV1
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BU of 5ev1 by Molmil
Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal
分子名称: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(*UP*UP*U)-D(P*UP*UP*(BRU)P*U)-R(P*UP*U)-3'), SODIUM ION, ...
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.037 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV2
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Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称: 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, DNA (5'-R(P*UP*U)-D(P*UP*U)-R(P*U)-D(P*UP*(BRU)P*U)-3'), ...
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV3
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Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)-3'), Splicing factor U2AF 65 kDa subunit
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV4
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Structure IV of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称: DNA/RNA (5'-R(P*UP*UP*UP*(UD)P*UP*U)-D(P*(BRU)P*(UD))-R(P*C)-3'), GLYCEROL, Splicing factor U2AF 65 kDa subunit
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
6N3D
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Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Loerch, S, Jenkins, J.L, Kielkopf, C.L.
登録日2018-11-15
公開日2019-01-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6NSX
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BU of 6nsx by Molmil
Yeast Hsh155 Ligand bound to Human Tat-SF1 Motif
分子名称: CHLORIDE ION, HIV Tat-specific factor 1, Hsh155
著者Jenkins, J.L, Leach, J.R, Kielkopf, C.L.
登録日2019-01-25
公開日2019-06-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction.
Rna, 25, 2019
6N3E
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BU of 6n3e by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
分子名称: FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ...
著者Loerch, S, Jenkins, J.L, Kielkopf, C.L.
登録日2018-11-15
公開日2019-01-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.893 Å)
主引用文献The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6N3F
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BU of 6n3f by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ...
著者Leach, J.R, Jenkins, J.L, Kielkopf, C.L.
登録日2018-11-15
公開日2019-01-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
3CGP
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BU of 3cgp by Molmil
X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex bound to iodide ions
分子名称: IODIDE ION, RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), ...
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGS
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BU of 3cgs by Molmil
X-ray structure containing the pseudouridylated U2 snRNA and mammalian intron branch site consensus sequences
分子名称: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*GP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3')
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGR
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BU of 3cgr by Molmil
X-ray structure containing the pseudouridylated U2 snRNA and intron branch site consensus sequences
分子名称: RNA (5'-R(*CP*GP*CP*AP*CP*UP*AP*AP*CP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*GP*(PSU)P*AP*GP*UP*GP*C)-3'), SULFATE ION
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGQ
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BU of 3cgq by Molmil
X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex
分子名称: RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), SULFATE ION
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
7S3C
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BU of 7s3c by Molmil
Crystal structure of intact U2AF65 RRM-region bound to AdML-A5 oligonucleotide
分子名称: DNA/RNA (5'-R(P*UP*UP*(UD)P*AP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
著者Glasser, E, Jenkins, J.L, Kielkopf, C.L.
登録日2021-09-05
公開日2022-05-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.
Nucleic Acids Res., 50, 2022
7S3B
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BU of 7s3b by Molmil
Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide
分子名称: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
著者Jenkins, J.L, Henderson, S, Kielkopf, C.L.
登録日2021-09-05
公開日2022-05-25
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.
Nucleic Acids Res., 50, 2022
3VAK
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BU of 3vak by Molmil
Structure of U2AF65 variant with BrU5 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ...
著者Jenkins, J.L, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAF
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BU of 3vaf by Molmil
Structure of U2AF65 variant with BrU3 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(*UP*UP*(BRU)P*(BRU)P*UP*UP*U)-3', GLYCEROL, ...
著者Jenkins, J.L, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAM
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BU of 3vam by Molmil
Structure of U2AF65 variant with BrU5C2 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*CP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ...
著者Jenkins, J.L, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAJ
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Structure of U2AF65 variant with BrU5C6 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*CP*U)-3'), GLYCEROL, ...
著者Jenkins, J.L, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAI
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BU of 3vai by Molmil
Structure of U2AF65 variant with BrU3C5 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(*UP*UP*(BRU)P*UP*CP*UP*U)-3', GLYCEROL, ...
著者Jenkins, J.L, Frato, K.H, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAH
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Structure of U2AF65 variant with BrU3C4 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(P*UP*UP*(BRU)P*CP*UP*UP*U)-3', GLYCEROL, ...
著者Jenkins, J.L, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013

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