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PDB: 80 results

8B79
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BU of 8b79 by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site
Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B7E
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The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site
Descriptor: CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B77
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The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8PJC
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Crystal structure of human insulin desB30 precursor with an Alanine-Alanine-Lysine C-peptide in dimer (T2) conformation
Descriptor: Insulin
Authors:Schluckebier, G, Johansson, E.
Deposit date:2023-06-23
Release date:2023-11-08
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PJH
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Crystal structure of human insulin desB30 precursor with an Aspartate-Glycine-Lysine C-peptide in dimer (T2) conformation
Descriptor: Insulin
Authors:Schluckebier, G, Johansson, E.
Deposit date:2023-06-23
Release date:2023-11-08
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
6H1V
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The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(P*AP*AP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-07-12
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Nucleic Acids Res., 47, 2019
6QIB
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The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2019-01-18
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Nucleic Acids Res., 47, 2019
6FWK
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The crystal structure of Pol2CORE-M644G in complex with DNA and an incoming nucleotide
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-03-06
Release date:2019-01-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
6G0A
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The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*DC)-3'), ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-03-16
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
6I8A
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BU of 6i8a by Molmil
The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-11-19
Release date:2019-01-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.652 Å)
Cite:Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
1FTD
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BU of 1ftd by Molmil
5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'-SYMMETRIC BIS-BENZIMIDAZOLE COMPLEX
Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, [3-(4-{2'-[4-(3-DIMETHYLAMINO-PROPOXY)-PHENYL]-3H,3'H-[5,5']BIBENZOIMIDAZOLYL-2-YL}-PHENOXY)-PROPYL]-DIMETHYL-AMINE
Authors:Mann, J, Baron, A, Opoku-Boahen, Y, Johansson, E, Parkinson, G, Kelland, L.R, Neidle, S.
Deposit date:2000-09-12
Release date:2001-02-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity.
J.Med.Chem., 44, 2001
1QHW
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BU of 1qhw by Molmil
PURPLE ACID PHOSPHATASE FROM RAT BONE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PROTEIN (PURPLE ACID PHOSPHATASE), ...
Authors:Lindqvist, Y, Johansson, E, Kaija, H, Vihko, P, Schneider, G.
Deposit date:1999-03-26
Release date:1999-09-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 A resolution with a mu-(hydr)oxo bridged di-iron center.
J.Mol.Biol., 291, 1999
1U9Z
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Crystal Structure of Phosphoribosyl Diphosphate Synthase Complexed with AMP and Ribose 5-Phosphate
Descriptor: ADENOSINE MONOPHOSPHATE, RIBOSE-5-PHOSPHATE, Ribose-phosphate pyrophosphokinase
Authors:Kadziola, A, Johansson, E, Jepsen, C.H, McGuire, J, Larsen, S, Hove-Jensen, B.
Deposit date:2004-08-11
Release date:2005-08-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii
J.Mol.Biol., 354, 2005
1U9Y
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BU of 1u9y by Molmil
Crystal Structure of Phosphoribosyl Diphosphate Synthase from Methanocaldococcus jannaschii
Descriptor: Ribose-phosphate pyrophosphokinase
Authors:Kadziola, A, Johansson, E, Jepsen, C.H, McGuire, J, Larsen, S, Hove-Jensen, B.
Deposit date:2004-08-11
Release date:2005-08-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii
J.Mol.Biol., 354, 2005
2BSL
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BU of 2bsl by Molmil
Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,4-dihydroxybenzoate
Descriptor: 3,4-DIHYDROXYBENZOIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE A, ...
Authors:Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A.
Deposit date:2005-05-23
Release date:2006-08-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
2BX7
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BU of 2bx7 by Molmil
Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,5-dihydroxybenzoate
Descriptor: 3,5-DIHYDROXYBENZOATE, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
Authors:Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A.
Deposit date:2005-07-25
Release date:2006-08-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
2J4J
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BU of 2j4j by Molmil
Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP and AMPPCP to 2.1 Angstrom resolution
Descriptor: COBALT (II) ION, MAGNESIUM ION, P1-(5'-ADENOSINE)P4-(5'-URIDINE)-BETA,GAMMA-METHYLENE TETRAPHOSPHATE, ...
Authors:Jensen, K.S, Johansson, E, Jensen, K.F.
Deposit date:2006-09-01
Release date:2007-02-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Enzymatic Investigation of the Sulfolobus Solfataricus Uridylate Kinase Shows Competitive Utp Inhibition and the Lack of GTP Stimulation
Biochemistry, 46, 2007
2J4K
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BU of 2j4k by Molmil
Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP to 2.2 Angstrom resolution
Descriptor: CADMIUM ION, MAGNESIUM ION, URIDINE-5'-MONOPHOSPHATE, ...
Authors:Jensen, K.S, Johansson, E, Jensen, K.F.
Deposit date:2006-09-01
Release date:2007-02-27
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Enzymatic Investigation of the Sulfolobus Solfataricus Uridylate Kinase Shows Competitive Utp Inhibition and the Lack of GTP Stimulation
Biochemistry, 46, 2007
1UUM
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BU of 1uum by Molmil
Rat dihydroorotate dehydrogenase (DHOD)in complex with atovaquone
Descriptor: 2-[4-(4-CHLOROPHENYL)CYCLOHEXYLIDENE]-3,4-DIHYDROXY-1(2H)-NAPHTHALENONE, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ...
Authors:Hansen, M, Le Nours, J, Johansson, E, Antal, T, Ullrich, A, Loffler, M, Larsen, S.
Deposit date:2004-01-06
Release date:2004-04-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain
Protein Sci., 13, 2004
1UUO
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BU of 1uuo by Molmil
Rat dihydroorotate dehydrogenase (DHOD)in complex with brequinar
Descriptor: 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ...
Authors:Hansen, M, Le Nours, J, Johansson, E, Antal, T, Ullrich, A, Loffler, M, Larsen, S.
Deposit date:2004-01-08
Release date:2004-04-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain
Protein Sci., 13, 2004
3NVA
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BU of 3nva by Molmil
Dimeric form of CTP synthase from Sulfolobus solfataricus
Descriptor: CTP synthase
Authors:Harris, P, Willemoes, M, Lauritsen, I, Johansson, E, Jensen, K.F.
Deposit date:2010-07-08
Release date:2010-09-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.504 Å)
Cite:Structure of the dimeric form of CTP synthase from Sulfolobus solfataricus
Acta Crystallogr.,Sect.F, 67, 2011
2J4L
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BU of 2j4l by Molmil
Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UTP to 2.8 Angstrom resolution
Descriptor: MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE, URIDYLATE KINASE
Authors:Jensen, K.S, Johansson, E, Jensen, K.F.
Deposit date:2006-09-01
Release date:2007-02-27
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Enzymatic Investigation of the Sulfolobus Solfataricus Uridylate Kinase Shows Competitive Utp Inhibition and the Lack of GTP Stimulation
Biochemistry, 46, 2007
2V9X
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E138D variant of Escherichia coli dCTP deaminase in complex with dUTP
Descriptor: DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, DEOXYURIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thymark, M, Johansson, E, Larsen, S, Willemoes, M.
Deposit date:2007-08-28
Release date:2007-11-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutational Analysis of the Nucleotide Binding Site of Escherichia Coli Dctp Deaminase.
Arch.Biochem.Biophys., 470, 2008
2HXB
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dCTP deaminase-dUTPase from Methanocaldococcus jannaschii
Descriptor: dCTP deaminase, dUMP-forming
Authors:Bynck, J.H, Johansson, E.
Deposit date:2006-08-03
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural evidence for a concerted Bifunctionality in dCTP deaminase-dUTPase from Methanocaldococcus jannaschii
To be Published
2HXD
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BU of 2hxd by Molmil
Bifunctional dCTP deaminase-dUTPase mutant enzyme variant E145A from Methanocaldococcus jannaschii in complex with alpha,beta-imido dUTP and magnesium
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, MAGNESIUM ION, dCTP deaminase, ...
Authors:Bynck, J.H, Johansson, E.
Deposit date:2006-08-03
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural evidence for a concerted Bifunctionality in dCTP deaminase-dUTPase from Methanocaldococcus jannaschii
To be Published

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