8I33
 
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6IY0
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5V7I
 | | Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), in complex with glycine, PLP and folate-competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | | 分子名称: | (4R)-6-amino-3-methyl-4-(propan-2-yl)-4-[3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Ducker, G.S, Ghergurovich, J.M, Mainolfi, N, Suri, V, Jeong, S, Friedman, A, Manfredi, M, Kim, H, Rabinowitz, J.D. | | 登録日 | 2017-03-20 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2R64
 | | Crystal structure of a 3-aminoindazole compound with CDK2 | | 分子名称: | Cell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE | | 著者 | Lee, J, Choi, H, Kim, K.H, Jeong, S, Park, J.W, Baek, C.S, Lee, S.H. | | 登録日 | 2007-09-05 | | 公開日 | 2008-09-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
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2DUV
 | | Structure of CDK2 with a 3-hydroxychromones | | 分子名称: | 2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE, Cell division protein kinase 2 | | 著者 | Kim, K.H, Lee, J, Park, T, Jeong, S, Hong, C. | | 登録日 | 2006-07-27 | | 公開日 | 2007-01-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
Bioorg.Med.Chem.Lett., 17, 2007
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3S2P
 | | Crystal structure of CDK2 with a 2-aminopyrimidine compound | | 分子名称: | (3S,4S)-1-{3-[2-amino-6-(propan-2-yl)pyrimidin-4-yl]-4-hydroxyphenyl}pyrrolidine-3,4-diol, Cyclin-dependent kinase 2 | | 著者 | Kim, K.-H, Lee, J, Jeong, S. | | 登録日 | 2011-05-17 | | 公開日 | 2011-07-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors
Bioorg.Med.Chem.Lett., 21, 2011
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5ZNX
 | | Crystal structure of CM14-treated HlyU from Vibrio vulnificus | | 分子名称: | Transcriptional activator | | 著者 | Park, N, Kim, S, Jo, I, Ahn, J, Hong, S, Jeong, S, Baek, Y. | | 登録日 | 2018-04-11 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.114 Å) | | 主引用文献 | Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species.
Sci Rep, 9, 2019
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6KUI
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6KWW
 | | HslU from Staphylococcus aureus | | 分子名称: | ATP-dependent protease ATPase subunit HslU | | 著者 | Ha, N.-C, Jeong, S. | | 登録日 | 2019-09-09 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Cleavage-Dependent Activation of ATP-Dependent Protease HslUV from Staphylococcus aureus .
Mol.Cells, 43, 2020
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6KR1
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7CT8
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7CT9
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7CTA
 | | Crystal structure of Cx-SAM bound CmoB from Vibrio vulnificus | | 分子名称: | (2S)-4-[{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(carboxylatomethyl)sulfonio] -2-ammoniobutanoate, SULFATE ION, tRNA U34 carboxymethyltransferase | | 著者 | Kim, J, Jeong, S. | | 登録日 | 2020-08-18 | | 公開日 | 2021-03-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural snapshots of CmoB in various states during wobble uridine modification of tRNA.
Biochem.Biophys.Res.Commun., 534, 2021
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