3S2P
Crystal structure of CDK2 with a 2-aminopyrimidine compound
Summary for 3S2P
| Entry DOI | 10.2210/pdb3s2p/pdb |
| Descriptor | Cyclin-dependent kinase 2, (3S,4S)-1-{3-[2-amino-6-(propan-2-yl)pyrimidin-4-yl]-4-hydroxyphenyl}pyrrolidine-3,4-diol (3 entities in total) |
| Functional Keywords | protein kinase, transferase, cell division protein kinase 2, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 34306.87 |
| Authors | Kim, K.-H.,Lee, J.,Jeong, S. (deposition date: 2011-05-17, release date: 2011-07-20, Last modification date: 2024-03-20) |
| Primary citation | Lee, J.,Kim, K.-H.,Jeong, S. Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors Bioorg.Med.Chem.Lett., 21:4203-4205, 2011 Cited by PubMed Abstract: A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities. PubMed: 21684737DOI: 10.1016/j.bmcl.2011.05.081 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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