4P2B
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4P37
| Crystal structure of the Megavirus polyadenylate synthase | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Priet, S, Lartigue, A, Claverie, J.M, Abergel, C. | Deposit date: | 2014-03-06 | Release date: | 2015-04-01 | Last modified: | 2015-04-29 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | mRNA maturation in giant viruses: variation on a theme. Nucleic Acids Res., 43, 2015
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7UCR
| Joint X-ray/neutron structure of the Sarcin-Ricin loop RNA | Descriptor: | SULFATE ION, Sarcin-Ricin loop RNA | Authors: | Harp, J.M, Egli, M.E, Pallan, P.S, Coates, L. | Deposit date: | 2022-03-17 | Release date: | 2022-07-20 | Last modified: | 2024-04-03 | Method: | NEUTRON DIFFRACTION (1 Å), X-RAY DIFFRACTION | Cite: | Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure. Nucleic Acids Res., 50, 2022
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7UKS
| Crystal structure of SOS1 with phthalazine inhibitor bound (compound 15) | Descriptor: | 4-methyl-N-{(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl}-7-(piperazin-1-yl)phthalazin-1-amine, Son of sevenless homolog 1 | Authors: | Gunn, R.J, Lawson, J.D, Ketcham, J.M, Marx, M.A. | Deposit date: | 2022-04-01 | Release date: | 2022-07-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. J.Med.Chem., 65, 2022
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7UKR
| Crystal Structure of SOS1 with MRTX0902, a Potent and Selective Inhibitor of the SOS1:KRAS Protein-Protein Interaction | Descriptor: | 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl)pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile, Son of sevenless homolog 1 | Authors: | Gunn, R.J, Lawson, J.D, Ketcham, J.M, Marx, M.A. | Deposit date: | 2022-04-01 | Release date: | 2022-07-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. J.Med.Chem., 65, 2022
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1PIV
| BINDING OF THE ANTIVIRAL DRUG WIN51711 TO THE SABIN STRAIN OF TYPE 3 POLIOVIRUS: STRUCTURAL COMPARISON WITH DRUG BINDING IN RHINOVIRUS 14 | Descriptor: | 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, MYRISTIC ACID, POLIOVIRUS TYPE 3 (SUBUNIT VP1), ... | Authors: | Hiremath, C.N, Grant, R.A, Filman, D.J, Hogle, J.M. | Deposit date: | 1995-02-02 | Release date: | 1995-06-03 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Binding of the antiviral drug WIN51711 to the sabin strain of type 3 poliovirus: structural comparison with drug binding in rhinovirus 14. Acta Crystallogr.,Sect.D, 51, 1995
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4TMA
| Crystal structure of gyrase bound to its inhibitor YacG | Descriptor: | DNA gyrase inhibitor YacG, DNA gyrase subunit A, DNA gyrase subunit B, ... | Authors: | Vos, S.M, Lyubimov, A.Y, Hershey, D.M, Schoeffler, A.J, Berger, J.M. | Deposit date: | 2014-05-31 | Release date: | 2014-07-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes Dev., 28, 2014
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4QNH
| Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a | Descriptor: | CALCIUM ION, Calmodulin, SULFATE ION, ... | Authors: | Zhang, M, Pascal, J.M, Logothetis, D.E, Zhang, J.F. | Deposit date: | 2014-06-17 | Release date: | 2014-08-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nat.Chem.Biol., 10, 2014
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4RM9
| Crystal structure of human ezrin in space group C2221 | Descriptor: | Ezrin | Authors: | Phang, J.M, Harrop, S.J, Davies, R, Duff, A.P, Wilk, K.E, Curmi, P.M.G. | Deposit date: | 2014-10-21 | Release date: | 2015-12-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin. Biochem. J., 473, 2016
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4S13
| Ferulic Acid Decarboxylase (FDC1) | Descriptor: | 4-ethenylphenol, Ferulic acid decarboxylase 1 | Authors: | Lee, S.G, Bhuiya, M.W, Yu, O, Jez, J.M. | Deposit date: | 2015-01-07 | Release date: | 2015-05-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.348 Å) | Cite: | Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae. Appl.Environ.Microbiol., 81, 2015
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1NK3
| VND/NK-2 HOMEODOMAIN/DNA COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | DNA (5'-D(*AP*CP*AP*GP*CP*CP*AP*CP*TP*TP*GP*AP*CP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*GP*TP*CP*AP*AP*GP*TP*GP*GP*CP*TP*GP*T)-3'), HOMEOBOX PROTEIN VND | Authors: | Gruschus, J.M, Tsao, D.H.H, Wang, L.-H, Nirenberg, M, Ferretti, J.A. | Deposit date: | 1998-05-06 | Release date: | 1998-12-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: basis of binding specificity. Biochemistry, 36, 1997
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1NK2
| VND/NK-2 HOMEODOMAIN/DNA COMPLEX, NMR, 20 STRUCTURES | Descriptor: | DNA (5'-D(*AP*CP*AP*GP*CP*CP*AP*CP*TP*TP*GP*AP*CP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*GP*TP*CP*AP*AP*GP*TP*GP*GP*CP*TP*GP*T)-3'), HOMEOBOX PROTEIN VND | Authors: | Gruschus, J.M, Tsao, D.H.H, Wang, L.-H, Nirenberg, M, Ferretti, J.A. | Deposit date: | 1998-05-06 | Release date: | 1999-02-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: basis of binding specificity. Biochemistry, 36, 1997
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4QYY
| Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State | Descriptor: | (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. | Deposit date: | 2014-07-26 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57, 2014
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4QQV
| Extracellular domains of mouse IL-3 beta receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-3 receptor class 2 subunit beta | Authors: | Jackson, C.J, Young, I.G, Murphy, J.M, Carr, P.D, Ewens, C.L, Dai, J, Ollis, D.L. | Deposit date: | 2014-06-30 | Release date: | 2014-09-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Crystal structure of the mouse interleukin-3 beta-receptor: insights into interleukin-3 binding and receptor activation. Biochem.J., 463, 2014
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4R6W
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4S1L
| Structure of Uranotaenia sapphirina cypovirus (CPV17) polyhedrin at 298 K | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, polyhedrin | Authors: | Ginn, H.M, Messerschmidt, M, Ji, X, Zhang, H, Axford, D, Gildea, R.J, Winter, G, Brewster, A.S, Hattne, J, Wagner, A, Grimes, J.M, Evans, G, Sauter, N.K, Sutton, G, Stuart, D.I. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data. Nat Commun, 6, 2015
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4RSO
| The structure of the neurotropic AAVrh.8 viral vector | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, CHLORIDE ION, Capsid protein VP1, ... | Authors: | Halder, S, Van Vliet, K, Smith, J.K, McKenna, R, Wilson, J.M, Agbandje-McKenna, M. | Deposit date: | 2014-11-10 | Release date: | 2016-04-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of neurotropic adeno-associated virus AAVrh.8. J.Struct.Biol., 192, 2015
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4TN0
| Crystal Structure of the C-terminal Periplasmic Domain of Phosphoethanolamine Transferase EptC from Campylobacter jejuni | Descriptor: | UPF0141 protein yjdB, ZINC ION | Authors: | Fage, C.D, Brown, D, Boll, J.M, Keatinge-Clay, A.T, Trent, M.S. | Deposit date: | 2014-06-02 | Release date: | 2014-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni. Acta Crystallogr.,Sect.D, 70, 2014
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4RM8
| Crystal structure of human ezrin in space group P21 | Descriptor: | Ezrin | Authors: | Phang, J.M, Harrop, S.J, Davies, R, Duff, A.P, Wilk, K.E, Curmi, P.M.G. | Deposit date: | 2014-10-20 | Release date: | 2015-12-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin. Biochem. J., 473, 2016
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4RPM
| Crystal structure of the SAT domain from the non-reducing fungal polyketide synthase CazM with bound hexanoyl | Descriptor: | HEXANOIC ACID, HEXANOYL-COENZYME A, SAT domain from CazM | Authors: | Winter, J.M, Cascio, D, Sawaya, M.R, Tang, Y. | Deposit date: | 2014-10-30 | Release date: | 2015-09-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. J.Am.Chem.Soc., 137, 2015
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4TQQ
| Photosynthetic Reaction Center from R. sphaeroides Analyzed at Room Temperature on an X-ray Transparent Microfluidic Chip | Descriptor: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, FE (II) ION, ... | Authors: | Schieferstein, J.M, Khvostichenko, D.S, Pawate, A.S, Kenis, P.J.A. | Deposit date: | 2014-06-11 | Release date: | 2014-07-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | X-ray Transparent Microfluidic Chip for Mesophase-Based Crystallization of Membrane Proteins and On-Chip Structure Determination. Cryst.Growth Des., 14, 2014
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4RMA
| Crystal structure of the FERM domain of human ezrin | Descriptor: | Ezrin, SULFATE ION | Authors: | Phang, J.M, Harrop, S.J, Duff, A.P, Wilk, K.E, Curmi, P.M.G. | Deposit date: | 2014-10-21 | Release date: | 2015-12-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin. Biochem. J., 473, 2016
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4S1K
| Structure of Uranotaenia sapphirina cypovirus (CPV17) polyhedrin at 100 K | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Polyhedrin | Authors: | Ginn, H.M, Messerschmidt, M, Ji, X, Zhang, H, Axford, D, Gildea, R.J, Winter, G, Brewster, A.S, Hattne, J, Wagner, A, Grimes, J.M, Evans, G, Sauter, N.K, Sutton, G, Stuart, D.I. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data. Nat Commun, 6, 2015
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4RKS
| Crystal Structure of Mevalonate-3-Kinase from Thermoplasma acidophilum (Mevalonate Bound) | Descriptor: | (R)-MEVALONATE, ACETATE ION, GLYCEROL, ... | Authors: | Vinokur, J.M, Cascio, D, Sawaya, M.R, Bowie, J.U. | Deposit date: | 2014-10-13 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. Protein Sci., 24, 2015
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4ROS
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