4RM8

Crystal structure of human ezrin in space group P21

Summary for 4RM8

Related4RM9 4RMA
DescriptorEzrin (2 entities in total)
Functional Keywordsferm domain, c-ermad domain, membrane cytoskeleton linkers, actin binding, peptide binding protein
Biological sourceHomo sapiens (human)
Cellular locationApical cell membrane ; Peripheral membrane protein ; Cytoplasmic side  P15311
Total number of polymer chains2
Total molecular weight139167.94
Authors
Phang, J.M.,Harrop, S.J.,Davies, R.,Duff, A.P.,Wilk, K.E.,Curmi, P.M.G. (deposition date: 2014-10-20, release date: 2015-12-09, Last modification date: 2017-09-27)
Primary citation
Phang, J.M.,Harrop, S.J.,Duff, A.P.,Sokolova, A.V.,Crossett, B.,Walsh, J.C.,Beckham, S.A.,Nguyen, C.D.,Davies, R.B.,Glockner, C.,Bromley, E.H.,Wilk, K.E.,Curmi, P.M.
Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
Biochem. J., 473:2763-2782, 2016
PubMed: 27364155 (PDB entries with the same primary citation)
DOI: 10.1042/BCJ20160541
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21330.1%0.6%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4rm8
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Molmil generated image of 4rm8
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Molmil generated image of 4rm8
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More Biological unit images

Molmil generated image of 4rm8
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Molmil generated image of 4rm8
rotated about x axis by 90°
Molmil generated image of 4rm8
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4rm8.pdb1.gz [136.99 KB])
Coordinate files for Biological unit (4rm8.pdb2.gz [136.19 KB])