2PY7
 
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9C8X
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9C8W
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9BYJ
 | | Crystal Structure of Hck in complex with the Src-family kinase inhibitor A-419259 | | 分子名称: | 1,2-ETHANEDIOL, 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, DIMETHYL SULFOXIDE, ... | | 著者 | Selzer, A.M, Alvarado, J.J, Smithgall, T.E. | | 登録日 | 2024-05-23 | | 公開日 | 2024-10-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Cocrystallization of the Src-Family Kinase Hck with the ATP-Site Inhibitor A-419259 Stabilizes an Extended Activation Loop Conformation.
Biochemistry, 63, 2024
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9GD1
 | | Structure of Chd1 bound to a hexasome-nucleosome complex with a dyad-to-dyad distance of 103 bp. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | | 登録日 | 2024-08-04 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
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9F6C
 | | Cardiac myosin motor domain in the pre-powerstroke state co-crystallized with the inhibitor aficamten | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-7, ... | | 著者 | Robert-Paganin, J, Hartman, J.J, Morgan, B.P, Malik, F.I, Houdusse, A. | | 登録日 | 2024-05-01 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Nat Cardiovasc Res, 3, 2024
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8Y2I
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9CE4
 | | Structure of CHK1 10-pt. mutant complex with LRRK2 indazole inhibitor compound 6 | | 分子名称: | (1S,4r)-4-[(1P)-5-chloro-1-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-6-yl]-1-(oxetan-3-yl)piperidin-1-ium, 1,2-ETHANEDIOL, Serine/threonine-protein kinase Chk1 | | 著者 | Palte, R.L, Zebisch, M, Henry, C, Barker, J.J. | | 登録日 | 2024-06-26 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors.
J.Med.Chem., 67, 2024
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9JE1
 | | Human URAT1 bound to dotinurad | | 分子名称: | Solute carrier family 22 member 12, dotinurad | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs
Biorxiv, 2024
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9JE0
 | | Human URAT1 bound to benzbromarone | | 分子名称: | Solute carrier family 22 member 12, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs
Biorxiv, 2024
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9F6D
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9LDT
 | | DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | | 著者 | Dunn, C.R, Holbrook, J.J, Muirhead, H. | | 登録日 | 1991-11-26 | | 公開日 | 1993-10-31 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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9F6L
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9C90
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9F6J
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9GD3
 | | Structure of a mononucleosome bound by one copy of Chd1 with the DBD on the exit-side DNA. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | | 登録日 | 2024-08-04 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
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9LDB
 | | DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | | 著者 | Dunn, C.R, Holbrook, J.J, Muirhead, H. | | 登録日 | 1991-11-26 | | 公開日 | 1993-10-31 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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8XYC
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9C8Z
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9F6E
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9C8Y
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9F6F
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9FSE
 | | Human ROR2 cysteine-rich domain (CRD) and Kringle domain | | 分子名称: | SULFATE ION, Tyrosine-protein kinase transmembrane receptor ROR2 | | 著者 | Griffiths, S.C, Tan, J, Wagner, A, Blazer, L.L, Adams, J.J, Srinivasan, S, Moghisaei, S, Sidhu, S.S, Siebold, C, Ho, H.H. | | 登録日 | 2024-06-20 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling.
Elife, 13, 2024
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9GD2
 | | Structure of Chd1 bound to a dinucleosome with a dyad-to-dyad distance of 103 bp. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | | 登録日 | 2024-08-04 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
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9F6K
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