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PDB: 2129 件
8TBG
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Tricomplex of RMC-7977, HRAS WT, and CypA
分子名称: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GLYCEROL, GTPase HRas, ...
著者Chen, A, Tomlinson, A.C.A, Knox, J.E, Yano, J.K.
登録日2023-06-28
公開日2024-02-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
8TBK
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Tricomplex of RMC-7977, KRAS G12C, and CypA
分子名称: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase KRas, MAGNESIUM ION, ...
著者Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K.
登録日2023-06-28
公開日2024-02-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
8TBJ
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Tricomplex of RMC-7977, KRAS G12A, and CypA
分子名称: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ...
著者Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K.
登録日2023-06-28
公開日2024-02-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
8TBI
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Tricomplex of RMC-7977, NRAS WT, and CypA
分子名称: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase NRas, MAGNESIUM ION, ...
著者Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K.
登録日2023-06-28
公開日2024-02-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
8TBL
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Tricomplex of RMC-7977, KRAS G12D, and CypA
分子名称: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase KRas, MAGNESIUM ION, ...
著者Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K.
登録日2023-06-28
公開日2024-02-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
8TBM
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Tricomplex of RMC-7977, KRAS G12V, and CypA
分子名称: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GLYCEROL, GTPase KRas, ...
著者Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K.
登録日2023-06-28
公開日2024-02-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
8TBN
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Tricomplex of RMC-7977, KRAS G12S, and CypA
分子名称: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase KRas, MAGNESIUM ION, ...
著者Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K.
登録日2023-06-28
公開日2024-02-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
4I8T
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C.Esp1396I bound to a 19 base pair DNA duplex
分子名称: DNA (5'-D(P*TP*GP*TP*GP*TP*GP*AP*TP*TP*AP*TP*AP*GP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(P*TP*GP*TP*TP*GP*AP*CP*TP*AP*TP*AP*AP*TP*CP*AP*CP*AP*CP*A)-3'), Regulatory protein
著者Martin, R.N.A, McGeehan, J.E, Kneale, G.G.
登録日2012-12-04
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural analysis of DNA-protein complexes regulating the restriction-modification system Esp1396I.
Acta Crystallogr.,Sect.F, 69, 2013
6TL4
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BU of 6tl4 by Molmil
Photosensory module (PAS-GAF-PHY) of Glycine max phyB
分子名称: PHYCOCYANOBILIN, Phytochrome
著者Nagano, S, Guan, K, Shenkutie, S.M, Hughes, J.E.
登録日2019-12-01
公開日2020-05-06
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural insights into photoactivation and signalling in plant phytochromes.
Nat.Plants, 6, 2020
6TQB
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BU of 6tqb by Molmil
X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE1 SL RNA motif
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ...
著者Binas, O, Tants, J.-N, Peter, S.A, Janowski, R, Davydova, E, Braun, J, Niessing, D, Schwalbe, H, Weigand, J.E, Schlundt, A.
登録日2019-12-16
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for the recognition of transiently structured AU-rich elements by Roquin.
Nucleic Acids Res., 48, 2020
5OMU
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BU of 5omu by Molmil
Crystal structure of Amycolatopsis cytochrome P450 GcoA in complex with syringol
分子名称: 2,6-dimethoxyphenol, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Mallinson, S.J.B, Johnson, C.W, Neidle, E.L, Beckham, G.T, McGeehan, J.E.
登録日2017-08-01
公開日2018-07-04
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion.
Nat Commun, 9, 2018
7LXG
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BU of 7lxg by Molmil
Homocitrullinated beta-lactamase OXA-48
分子名称: Beta-lactamase, CHLORIDE ION, SULFATE ION
著者Serrano-Negron, J.E, King, D.T, Vocadlo, D.J.
登録日2021-03-03
公開日2022-05-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Chemoproteomic identification of CO 2 -dependent lysine carboxylation in proteins.
Nat.Chem.Biol., 18, 2022
5OMS
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BU of 5oms by Molmil
Crystal structure of Amycolatopsis cytochrome P450 GcoA in complex with guaethol.
分子名称: 2-ethoxyphenol, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Mallinson, S.J.B, Johnson, C.W, Neidle, E.L, Beckham, G.T, McGeehan, J.E.
登録日2017-08-01
公開日2018-07-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion.
Nat Commun, 9, 2018
6UGL
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VqmA bound to DPO
分子名称: 3,5-dimethylpyrazin-2(1H)-one, Helix-turn-helix transcriptional regulator
著者Paczkowski, J.E, Huang, X.
登録日2019-09-26
公開日2020-01-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Mechanism underlying autoinducer recognition in theVibrio choleraeDPO-VqmA quorum-sensing pathway.
J.Biol.Chem., 295, 2020
7MJS
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BU of 7mjs by Molmil
Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2AG3 Fab heavy chain, 2AG3 Fab light chain, ...
著者Cater, R.J, Chua, G.L, Erramilli, S.K, Keener, J.E, Choy, B.C, Tokarz, P, Chin, C.F, Quek, D.Q.Y, Kloss, B, Pepe, J.G, Parisi, G, Wong, B.H, Clarke, O.B, Marty, M.T, Kossiakoff, A.A, Khelashvili, G, Silver, D.L, Mancia, F.
登録日2021-04-20
公開日2021-06-16
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Nature, 595, 2021
7MEZ
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Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex
分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 5
著者Burke, J.E, Dalwadi, U, Rathinaswamy, M.K, Yip, C.K.
登録日2021-04-08
公開日2021-07-14
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structure of the phosphoinositide 3-kinase (PI3K) p110 gamma-p101 complex reveals molecular mechanism of GPCR activation.
Sci Adv, 7, 2021
5OMR
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BU of 5omr by Molmil
Crystal structure of Amycolatopsis cytochrome P450 GcoA in complex with vanillin.
分子名称: 4-hydroxy-3-methoxybenzaldehyde, GcoA, PROTOPORPHYRIN IX CONTAINING FE
著者Mallinson, S.J.B, Johnson, C.W, Neidle, E.L, Beckham, G.T, McGeehan, J.E.
登録日2017-08-01
公開日2018-07-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion.
Nat Commun, 9, 2018
1AT1
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BU of 1at1 by Molmil
CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
分子名称: ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ...
著者Gouaux, J.E, Lipscomb, W.N.
登録日1989-09-22
公開日1990-10-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
5UQY
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BU of 5uqy by Molmil
Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP1, ...
著者Hashiguchi, T, Fusco, M.L, Hastie, K.M, Bomholdt, Z.A, Lee, J.E, Flyak, A.I, Matsuoka, R, Kohda, D, Yanagi, Y, Hammel, M, Crowe, J.E, Saphire, E.O.
登録日2017-02-08
公開日2017-03-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
1W0K
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BU of 1w0k by Molmil
ADP inhibited bovine F1-ATPase
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL PRECURSOR, ...
著者Kagawa, R, Montgomery, M.G, Braig, K, Walker, J.E, Leslie, A.G.W.
登録日2004-06-08
公開日2004-07-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The Structure of Bovine F1-ATPase Inhibited by Adp and Beryllium Fluoride
Embo J., 23, 2004
1W0J
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Beryllium fluoride inhibited bovine F1-ATPase
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL PRECURSOR, ...
著者Kagawa, R, Montgomery, M.G, Braig, K, Walker, J.E, Leslie, A.G.W.
登録日2004-06-08
公開日2004-07-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Structure of Bovine F1-ATPase Inhibited by Adp and Beryllium Fluoride
Embo J., 23, 2004
1HZ3
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BU of 1hz3 by Molmil
ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35)
分子名称: A-BETA AMYLOID
著者Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P.
登録日2001-01-23
公開日2001-01-31
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
J.Struct.Biol., 130, 2000
4IWR
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C.Esp1396I bound to a 25 base pair operator site
分子名称: DNA (25-MER), Regulatory protein
著者Martin, R.N.A, McGeehan, J.E, Ball, N.J, Streeter, S.D, Thresh, S.-J, Kneale, G.G.
登録日2013-01-24
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural analysis of DNA-protein complexes regulating the restriction-modification system Esp1396I.
Acta Crystallogr.,Sect.F, 69, 2013
1NOV
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NODAMURA VIRUS
分子名称: NODAMURA VIRUS COAT PROTEINS
著者Natarajan, P, Johnson, J.E.
登録日1997-09-16
公開日1998-01-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Resolution of space-group ambiguity and structure determination of nodamura virus to 3.3 A resolution from pseudo-R32 (monoclinic) crystals.
Acta Crystallogr.,Sect.D, 53, 1997
3LFP
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Crystal Structure of the Restriction-Modification Controller Protein C.Csp231I
分子名称: Csp231I C protein
著者McGeehan, J.E, Streeter, S.D, Thresh, S.J, Kneale, G.G.
登録日2010-01-18
公開日2011-02-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of a Novel Class of R-M Controller Proteins: C.Csp231I from Citrobacter sp. RFL231.
J.Mol.Biol., 409, 2011

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