6SJT
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8EPQ
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8EPN
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6RFK
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6S4S
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8EPP
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4PLX
| Crystal structure of the triple-helical stability element at the 3' end of MALAT1 | 分子名称: | Core ENE hairpin and A-rich tract from MALAT1 | 著者 | Brown, J.A, Bulkley, D, Wang, J, Valenstein, M.L, Yario, T.A, Steitz, T.A, Steitz, J.A. | 登録日 | 2014-05-19 | 公開日 | 2014-06-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix. Nat.Struct.Mol.Biol., 21, 2014
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6R5V
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8ELU
| HRAS R97G Crystal form 1 | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Johnson, C.W, Rodrigues, J.A, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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6R5T
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6R7O
| Crystal structure of the central region of human cohesin subunit STAG1 | 分子名称: | Cohesin subunit SA-1 | 著者 | Newman, J.A, katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2019-03-29 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. Life Sci Alliance, 3, 2020
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8EML
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6R5N
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6R5O
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6R5I
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6ST2
| Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs | 分子名称: | Affimer AF6, Bcl-2-like protein 1, SULFATE ION | 著者 | Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A. | 登録日 | 2019-09-09 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*. Chembiochem, 22, 2021
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6SMB
| Human jak1 kinase domain in complex with inhibitor | 分子名称: | Tyrosine-protein kinase JAK1, ~{N}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{H}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | 著者 | Read, J.A, Steuber, H. | 登録日 | 2019-08-21 | 公開日 | 2020-04-29 | 最終更新日 | 2020-05-27 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. J.Med.Chem., 63, 2020
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6R5P
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6RBI
| Crystal structure of KDM5B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol | 分子名称: | 1,2-ETHANEDIOL, 5-(1~{H}-1,2,3,4-tetrazol-5-yl)quinolin-8-ol, Lysine-specific demethylase 5B,Lysine-specific demethylase 5B, ... | 著者 | Johansson, C, Newman, J.A, Kawamura, A, Schofield, C.J, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | 登録日 | 2019-04-10 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystal structure of KDM5B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol To Be Published
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6R5U
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6SXW
| Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638) | 分子名称: | SULFATE ION, Zinc finger protein 638 | 著者 | Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2019-09-26 | 公開日 | 2019-10-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638) To Be Published
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8FK3
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6SKW
| Crystal structure of the Legionella pneumophila type II secretion system substrate NttE | 分子名称: | 1,2-ETHANEDIOL, NttE | 著者 | Portlock, T.J, Rehman, S, Garnett, J.A. | 登録日 | 2019-08-16 | 公開日 | 2020-05-20 | 最終更新日 | 2020-07-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure, Dynamics and Cellular Insight Into Novel Substrates of theLegionella pneumophilaType II Secretion System. Front Mol Biosci, 7, 2020
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6SM8
| Human jak1 kinase domain in complex with inhibitor | 分子名称: | 1,2-ETHANEDIOL, 2-chloranyl-6-[(3~{S})-3-[(1~{S})-2-cyano-1-[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile, Tyrosine-protein kinase JAK1 | 著者 | Read, J.A, Steuber, H. | 登録日 | 2019-08-21 | 公開日 | 2020-04-29 | 最終更新日 | 2020-05-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. J.Med.Chem., 63, 2020
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6SSB
| syk in complex with compound 30 | 分子名称: | Tyrosine-protein kinase SYK, ~{N}-[4-[5-[(dimethylamino)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-yl]-3-methyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)imidazo[1,5-a]pyridin-7-amine | 著者 | Read, J.A. | 登録日 | 2019-09-06 | 公開日 | 2020-09-30 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Discovery of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors To Be Published
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