5U2B
| Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide | 分子名称: | (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol, Estrogen receptor | 著者 | Nwachukwu, J.C, Nowak, J, Carlson, K.E, Katzenellenbogen, J.A, Nettles, K.W. | 登録日 | 2016-11-30 | 公開日 | 2017-04-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Mol. Cell, 65, 2017
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5U83
| Crystal structure of a MerB-trimethytin complex. | 分子名称: | ACETATE ION, Alkylmercury lyase, BROMIDE ION, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-13 | 公開日 | 2017-01-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.609 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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6EQI
| Structure of PINK1 bound to ubiquitin | 分子名称: | GLYCEROL, Nb696, Serine/threonine-protein kinase PINK1, ... | 著者 | Schubert, A.F, Gladkova, C, Pardon, E, Wagstaff, J.L, Freund, S.M.V, Steyaert, J, Maslen, S, Komander, D. | 登録日 | 2017-10-13 | 公開日 | 2017-11-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of PINK1 in complex with its substrate ubiquitin. Nature, 552, 2017
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7DK2
| Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MW07 heavy chain, MW07 light chain, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M, Chen, S. | 登録日 | 2020-11-22 | 公開日 | 2021-12-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Architectural versatility of spike neutralization by a SARS-CoV-2 antibody To Be Published
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5UCK
| Class II fructose-1,6-bisphosphate aldolase of Helicobacter pylori with cleavage products | 分子名称: | 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase, GLYCERALDEHYDE-3-PHOSPHATE, ... | 著者 | Jacques, B, Sygusch, J. | 登録日 | 2016-12-22 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.782 Å) | 主引用文献 | Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. J. Biol. Chem., 293, 2018
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2IVU
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3SOA
| Full-length human CaMKII | 分子名称: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker | 著者 | Chao, L.H, Kuriyan, J. | 登録日 | 2011-06-30 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.5501 Å) | 主引用文献 | A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme. Cell(Cambridge,Mass.), 146, 2011
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2IEE
| Crystal Structure of YCKB_BACSU from Bacillus subtilis. Northeast Structural Genomics Consortium target SR574. | 分子名称: | Probable ABC transporter extracellular-binding protein yckB | 著者 | Kuzin, A.P, Su, M, Jayaraman, S, Chen, X.C, Jang, M, Cunningham, K, Ma, C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-09-18 | 公開日 | 2006-10-03 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of probable ABC transporter extracellular-binding protein yckB from Bacillus subtilis. To be Published
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3SQV
| Crystal Structure of E. coli O157:H7 E3 ubiquitin ligase, NleL, with a human E2, UbcH7 | 分子名称: | GLYCEROL, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3, ... | 著者 | Lin, D.Y, Chen, J. | 登録日 | 2011-07-06 | 公開日 | 2012-01-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
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2UZ5
| Solution structure of the fkbp-domain of Legionella pneumophila Mip | 分子名称: | MACROPHAGE INFECTIVITY POTENTIATOR | 著者 | Ceymann, A, Horstmann, M, Ehses, P, Schweimer, K, Steinert, M, Kamphausen, T, Fischer, G, Hacker, J, Rosch, P, Faber, C. | 登録日 | 2007-04-25 | 公開日 | 2007-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Domain Motions of the Mip Protein from Legionella Pneumophila Biochemistry, 45, 2006
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2UTG
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5U16
| Structure of human MR1-2-OH-1-NA in complex with human MAIT A-F7 TCR | 分子名称: | 2-hydroxynaphthalene-1-carbaldehyde, Beta-2-microglobulin, CHLORIDE ION, ... | 著者 | Keller, A.N, Birkinshaw, R.W, Rossjohn, J. | 登録日 | 2016-11-27 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nat. Immunol., 18, 2017
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5U7C
| Crystal structure of the lead-bound form of MerB formed from diethyllead. | 分子名称: | ACETATE ION, Alkylmercury lyase, BROMIDE ION, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-12 | 公開日 | 2017-01-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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5U82
| Crystal structure of a MerB-triethyltin complex | 分子名称: | ACETATE ION, Alkylmercury lyase, BROMIDE ION, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-13 | 公開日 | 2017-01-11 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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2IYO
| Structural characterization of a bacterial 6PDH reveals aspects of specificity, mechanism and mode of inhibition | 分子名称: | 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING, 6-PHOSPHOGLUCONIC ACID, ... | 著者 | Sundaramoorthy, R, Iulek, J, Hunter, W.N. | 登録日 | 2006-07-21 | 公開日 | 2007-01-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structures of a Bacterial 6-Phosphogluconate Dehydrogenase Reveal Aspects of Specificity, Mechanism and Mode of Inhibition by Analogues of High-Energy Reaction Intermediates. FEBS J., 274, 2007
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6FER
| Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide | 分子名称: | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide, Discoidin domain-containing receptor 2 | 著者 | Stihle, M, Richter, H, Benz, J, Kuhn, B, Rudolph, M.G. | 登録日 | 2018-01-03 | 公開日 | 2018-11-28 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome. Acs Chem.Biol., 14, 2019
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6EWY
| RipA Peptidoglycan hydrolase (Rv1477, Mycobacterium tuberculosis) N-terminal domain | 分子名称: | Peptidoglycan endopeptidase RipA | 著者 | Schnell, R, Steiner, E.M, Schneider, G, Guy, J, Bourenkov, G. | 登録日 | 2017-11-07 | 公開日 | 2018-05-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity. Proteins, 86, 2018
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3T72
| PhoB(E)-Sigma70(4)-(RNAP-Betha-flap-tip-helix)-DNA Transcription Activation Sub-Complex | 分子名称: | PHO BOX DNA (STRAND 1), PHO BOX DNA (STRAND 2), Phosphate regulon transcriptional regulatory protein phoB, ... | 著者 | Blanco, A.G, Canals, A, Bernues, J, Sola, M, Coll, M. | 登録日 | 2011-07-29 | 公開日 | 2011-09-21 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (4.33 Å) | 主引用文献 | The structure of a transcription activation subcomplex reveals how sigma (70) is recruited to PhoB promoters. Embo J., 30, 2011
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5UD2
| Class II fructose-1,6-bisphosphate aldolase H180Q variant of Helicobacter pylori with DHAP | 分子名称: | 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase, SODIUM ION, ... | 著者 | Jacques, B, Sygusch, J. | 登録日 | 2016-12-23 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.775 Å) | 主引用文献 | Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. J. Biol. Chem., 293, 2018
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2JDM
| Mutant (S22A) of Pseudomonas aeruginosa lectin II (PA-IIL) complexed with methyl-a-L-fucopyranoside | 分子名称: | CALCIUM ION, FUCOSE-BINDING LECTIN PA-IIL, SULFATE ION, ... | 著者 | Adam, J, Pokorna, M, Sabin, C, Mitchell, E.P, Imberty, A, Wimmerova, M. | 登録日 | 2007-01-11 | 公開日 | 2007-06-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Engineering of Pa-Iil Lectin from Pseudomonas Aeruginosa - Unravelling the Role of the Specificity Loop for Sugar Preference. Bmc Struct.Biol., 7, 2007
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3RUQ
| Crystal structure of Cpn-WT in complex with ADP from Methanococcus maripaludis | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin, MAGNESIUM ION | 著者 | Pereira, J.H, Ralston, C.Y, Douglas, N.R, Kumar, R, McAndrew, R.P, Knee, K.M, Frydman, J, Adams, P.D. | 登録日 | 2011-05-05 | 公開日 | 2012-01-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.798 Å) | 主引用文献 | Mechanism of nucleotide sensing in group II chaperonins. Embo J., 31, 2012
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3FM0
| Crystal structure of WD40 protein Ciao1 | 分子名称: | Protein CIAO1, SULFATE ION | 著者 | Dong, A, Ravichandran, M, Crombet, L, Cossar, D, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-12-19 | 公開日 | 2009-02-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
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6EY0
| N-terminal part (residues 30-212) of PorM with the llama nanobody nb01 | 分子名称: | T9SS component cytoplasmic membrane protein PorM, llama nanobody nb01 | 著者 | Leone, P, Roche, J, Cambillau, C, Roussel, A. | 登録日 | 2017-11-10 | 公開日 | 2018-02-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space. Nat Commun, 9, 2018
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6EWS
| Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12A-NDD | 分子名称: | NRPS Kj12A-NDD | 著者 | Hacker, C, Cai, X, Kegler, C, Zhao, L, Weickhmann, A.K, Bode, H.B, Woehnert, J. | 登録日 | 2017-11-06 | 公開日 | 2018-10-31 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. Nat Commun, 9, 2018
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3RUS
| Crystal structure of Cpn-rls in complex with ADP from Methanococcus maripaludis | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin, MAGNESIUM ION, ... | 著者 | Pereira, J.H, Ralston, C.Y, Douglas, N.R, Kumar, R, McAndrew, R.P, Knee, K.M, King, J.A, Frydman, J, Adams, P.D. | 登録日 | 2011-05-05 | 公開日 | 2012-01-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.338 Å) | 主引用文献 | Mechanism of nucleotide sensing in group II chaperonins. Embo J., 31, 2012
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