8CBZ
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8CQY
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![BU of 8cqy by Molmil](/molmil-images/mine/8cqy) | Crystal structure of the PTPN3 PDZ domain bound to the PBM TACE C-terminal peptide | 分子名称: | Disintegrin and metalloproteinase domain-containing protein 17, SODIUM ION, Tyrosine-protein phosphatase non-receptor type 3 | 著者 | Genera, M, Colcombet-Cazenave, B, Croitoru, A, Raynal, B, Mechaly, A, Caillet, J, Haouz, A, Wolff, N, Caillet-Saguy, C. | 登録日 | 2023-03-07 | 公開日 | 2023-05-10 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity. Front Mol Biosci, 10, 2023
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6I58
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![BU of 6i58 by Molmil](/molmil-images/mine/6i58) | Allosteric activation of human prekallikrein by apple domain disc rotation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Li, C, Pathak, M, McCrae, K, Dreveny, I, Emsley, J. | 登録日 | 2018-11-13 | 公開日 | 2019-03-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. J.Thromb.Haemost., 17, 2019
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6KVP
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![BU of 6kvp by Molmil](/molmil-images/mine/6kvp) | S. aureus FtsZ in complex with 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)-2,6-difluorobenzamide (compound 2) | 分子名称: | 3-[(1R)-1-[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]ethoxy]-2,6-bis(fluoranyl)benzamide, CALCIUM ION, Cell division protein FtsZ, ... | 著者 | Ferrer-Gonzalez, E, Fujita, J, Yoshizawa, T, Nelson, J.M, Pilch, A.J, Hillman, E, Ozawa, M, Kuroda, N, Parhi, A.K, LaVoie, E.J, Matsumura, H, Pilch, D.S. | 登録日 | 2019-09-05 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens. Sci Rep, 9, 2019
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8CIM
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![BU of 8cim by Molmil](/molmil-images/mine/8cim) | BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA.2-07 FAB HEAVY CHAIN, ... | 著者 | Duyvesteyn, H.M.E, Ren, J, Stuart, D.I, Fry, E.E. | 登録日 | 2023-02-10 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Isolation of a pair of potent broadly neutralizing mAb binding to RBD and SD1 domains of SARS-CoV-2 Res Sq, 2023
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2N3A
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![BU of 2n3a by Molmil](/molmil-images/mine/2n3a) | Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404) | 分子名称: | PC4 and SFRS1-interacting protein, Pogo transposable element with ZNF domain | 著者 | Tesina, P, Cermakova, K, Horejsi, M, Prochazkova, K, Fabry, M, Sharma, S, Christ, F, Demeulemeester, J, Debyser, Z, De Rijck, J, Veverka, V, Rezacova, P. | 登録日 | 2015-05-26 | 公開日 | 2015-08-19 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nat Commun, 6, 2015
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5EZZ
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![BU of 5ezz by Molmil](/molmil-images/mine/5ezz) | CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH (4S)-4-[3-(5-chloro-3-pyridyl)phenyl]-4-[4-(difluoromethoxy)-3-methyl-phenyl]-5H-oxazol-2-amine | 分子名称: | (4~{S})-4-[4-[bis(fluoranyl)methoxy]-3-methyl-phenyl]-4-[3-(5-chloranylpyridin-3-yl)phenyl]-5~{H}-1,3-oxazol-2-amine, Beta-secretase 1, DIMETHYL SULFOXIDE, ... | 著者 | Banner, D, Benz, J, Stihle, M, Kuglstatter, A. | 登録日 | 2015-11-27 | 公開日 | 2016-02-24 | 最終更新日 | 2016-05-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Real-World Perspective on Molecular Design. J.Med.Chem., 59, 2016
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1WBV
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![BU of 1wbv by Molmil](/molmil-images/mine/1wbv) | Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. | 分子名称: | 3-FLUORO-N-1H-INDOL-5-YL-5-MORPHOLIN-4-YLBENZAMIDE, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Tickle, J, Cleasby, A, Devine, L.A, Jhoti, H. | 登録日 | 2004-11-05 | 公開日 | 2005-11-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation. J.Med.Chem., 48, 2005
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8CJ3
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![BU of 8cj3 by Molmil](/molmil-images/mine/8cj3) | Urea-based foldamer inhibitor c3u_7 chimera in complex with ASF1 histone chaperone | 分子名称: | Histone chaperone ASF1A, c3u_7 chimera inhibitor of histone chaperone ASF1 | 著者 | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | 登録日 | 2023-02-11 | 公開日 | 2023-07-05 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach. Chem.Commun.(Camb.), 59, 2023
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1WBW
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![BU of 1wbw by Molmil](/molmil-images/mine/1wbw) | Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. | 分子名称: | 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE, MITOGEN-ACTIVATED PROTEIN KINASE 14 | 著者 | Tickle, J, Cleasby, A, Devine, L.A, Jhoti, H. | 登録日 | 2004-11-05 | 公開日 | 2005-11-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation J.Med.Chem., 48, 2005
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8CJ2
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![BU of 8cj2 by Molmil](/molmil-images/mine/8cj2) | Urea-based foldamer inhibitor c3u_5 chimera in complex with ASF1 histone chaperone | 分子名称: | GLYCEROL, Histone chaperone ASF1A, SULFATE ION, ... | 著者 | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | 登録日 | 2023-02-11 | 公開日 | 2023-07-05 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.127 Å) | 主引用文献 | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach. Chem.Commun.(Camb.), 59, 2023
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8CJ1
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![BU of 8cj1 by Molmil](/molmil-images/mine/8cj1) | Urea-based foldamer inhibitor c3u_3 chimera in complex with ASF1 histone chaperone | 分子名称: | Histone chaperone ASF1A, c3u_3 chimera inhibitor of histone chaperone ASF1 | 著者 | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | 登録日 | 2023-02-11 | 公開日 | 2023-07-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.564 Å) | 主引用文献 | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach. Chem.Commun.(Camb.), 59, 2023
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8CI5
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![BU of 8ci5 by Molmil](/molmil-images/mine/8ci5) | Structure of the SNV L protein bound to 5' RNA | 分子名称: | RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*U)-3'), RNA-directed RNA polymerase L | 著者 | Meier, K, Thorkelsson, S.R, Durieux Trouilleton, Q, Vogel, D, Yu, D, Kosinski, J, Cusack, S, Malet, H, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | 登録日 | 2023-02-08 | 公開日 | 2023-07-19 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional characterization of the Sin Nombre virus L protein. Plos Pathog., 19, 2023
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8CAI
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![BU of 8cai by Molmil](/molmil-images/mine/8cai) | Streptomycin and Hygromycin B bound to the 30S body | 分子名称: | 16S rRNA, 30S ribosomal protein S16, 30S ribosomal protein S2, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | 登録日 | 2023-01-24 | 公開日 | 2023-07-26 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.08 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8CGI
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![BU of 8cgi by Molmil](/molmil-images/mine/8cgi) | Pentacycline TP038 bound to the 30S head | 分子名称: | 16S rRNA, 30S ribosomal protein S7, Large ribosomal subunit protein bL31A, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | 登録日 | 2023-02-04 | 公開日 | 2023-07-26 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (1.89 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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5F03
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![BU of 5f03 by Molmil](/molmil-images/mine/5f03) | TRYPTASE B2 IN COMPLEX WITH 5-(3-Aminomethyl-phenoxymethyl)-3-[3-(2-chloro-pyridin-3-ylethynyl)-phenyl]-oxazolidin-2-one; compound with trifluoro-acetic acid | 分子名称: | (5~{S})-5-[[3-(aminomethyl)phenoxy]methyl]-3-[3-[2-(2-chloranylpyridin-3-yl)ethynyl]phenyl]-1,3-oxazolidin-2-one, Tryptase beta-2 | 著者 | Banner, D, Benz, J, Joseph, C, Kuglstatter, A. | 登録日 | 2015-11-27 | 公開日 | 2016-02-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | A Real-World Perspective on Molecular Design. J.Med.Chem., 59, 2016
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8CGU
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![BU of 8cgu by Molmil](/molmil-images/mine/8cgu) | Gentamicin bound to the 30S body | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 16S rRNA, 23S rRNA, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | 登録日 | 2023-02-06 | 公開日 | 2023-07-26 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (1.89 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8CAM
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![BU of 8cam by Molmil](/molmil-images/mine/8cam) | Evernimicin bound to the 50S subunit | 分子名称: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | 登録日 | 2023-01-24 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.86 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8CGV
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![BU of 8cgv by Molmil](/molmil-images/mine/8cgv) | Tiamulin bound to the 50S subunit | 分子名称: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | 登録日 | 2023-02-06 | 公開日 | 2023-08-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.66 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8COL
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![BU of 8col by Molmil](/molmil-images/mine/8col) | Crystal structure of Rhizobium etli constitutive L-asparaginase ReAIV (orthorombic form R4oP-2) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Loch, J.I, Worsztynowicz, P, Sliwiak, J, Imioloczyk, B, Grzechowiak, M, Gilski, M, Jaskolski, M. | 登録日 | 2023-02-28 | 公開日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center. Acta Crystallogr D Struct Biol, 79, 2023
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8CLZ
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![BU of 8clz by Molmil](/molmil-images/mine/8clz) | Crystal structure of Rhizobium etli constitutive L-asparaginase ReAIV (monoclinic form R4mC-2) | 分子名称: | CHLORIDE ION, Putative L-asparaginase II protein, ZINC ION | 著者 | Loch, J.I, Worsztynowicz, P, Sliwiak, J, Imiolczyk, B, Grzechowiak, M, Gilski, M, Jaskolski, M. | 登録日 | 2023-02-17 | 公開日 | 2023-08-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center. Acta Crystallogr D Struct Biol, 79, 2023
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8CLY
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![BU of 8cly by Molmil](/molmil-images/mine/8cly) | Crystal structure of Rhizobium etli constitutive L-asparaginase ReAIV (tetragonal form R4tP) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Putative L-asparaginase II protein, ... | 著者 | Loch, J.I, Worsztynowicz, P, Sliwiak, J, Imiolczyk, B, Grzechowiak, M, Gilski, M, Jaskolski, M. | 登録日 | 2023-02-17 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | 主引用文献 | Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center. Acta Crystallogr D Struct Biol, 79, 2023
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8C8U
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![BU of 8c8u by Molmil](/molmil-images/mine/8c8u) | Priestia megaterium mupirocin-resistant isoleucyl-tRNA synthetase 2 complexed with mupirocin | 分子名称: | Isoleucine--tRNA ligase, L(+)-TARTARIC ACID, MUPIROCIN, ... | 著者 | Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Gruic-Sovulj, I, Ban, N. | 登録日 | 2023-01-21 | 公開日 | 2023-08-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14, 2023
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8C9G
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![BU of 8c9g by Molmil](/molmil-images/mine/8c9g) | Priestia megaterium mupirocin-sensitive isoleucyl-tRNA synthetase 1 complexed with mupirocin | 分子名称: | CHLORIDE ION, GLYCEROL, Isoleucine--tRNA ligase, ... | 著者 | Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I. | 登録日 | 2023-01-22 | 公開日 | 2023-08-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14, 2023
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8C8W
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![BU of 8c8w by Molmil](/molmil-images/mine/8c8w) | Priestia megaterium mupirocin hyper-resistant HIGH motif mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue | 分子名称: | D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ... | 著者 | Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I. | 登録日 | 2023-01-21 | 公開日 | 2023-08-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14, 2023
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