2P69
| Crystal Structure of Human Pyridoxal Phosphate Phosphatase with PLP | 分子名称: | CALCIUM ION, PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate phosphatase | 著者 | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2007-03-16 | 公開日 | 2007-04-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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5WPT
| Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | 著者 | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | 登録日 | 2017-08-07 | 公開日 | 2017-10-18 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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2P0K
| Crystal structure of SCMH1 | 分子名称: | CHLORIDE ION, PHOSPHATE ION, Polycomb protein SCMH1 | 著者 | Herzanych, N, Senisterra, G, Liu, Y, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2007-02-28 | 公開日 | 2007-03-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure of SCMH1 To be Published
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2WIK
| NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Carletti, E, Aurbek, N, Gillon, E, Loiodice, M, Nicolet, Y, Fontecilla, J, Masson, P, Thiermann, H, Nachon, F, Worek, F. | 登録日 | 2009-05-12 | 公開日 | 2009-05-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. Biochem. J., 421, 2009
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3S8S
| Crystal structure of the RRM domain of human SETD1A | 分子名称: | Histone-lysine N-methyltransferase SETD1A, UNKNOWN ATOM OR ION | 著者 | Chao, X, Tempel, W, Bian, C, Cerovina, T, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2011-05-30 | 公開日 | 2011-06-08 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of the RRM domain of human SETD1A to be published
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2X12
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8AY5
| Human rhinovirus 2 empty particle in situ | 分子名称: | Capsid protein VP1, Capsid protein VP2, VP3 | 著者 | Ishemgulova, A, Mukhamedova, L, Trebichalska, Z, Payne, P, Smerdova, L, Moravcova, J, Hrebik, D, Buchta, D, Skubnik, K, Fuzik, T, Novacek, J, Plevka, P. | 登録日 | 2022-09-01 | 公開日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | 主引用文献 | Endosome rupture enables enteroviruses to infect cells. To Be Published
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8AY4
| Human rhinovirus 2 virion in situ | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Ishemgulova, A, Mukhamedova, L, Trebichalska, Z, Payne, P, Smerdova, L, Moravcova, J, Hrebik, D, Buchta, D, Skubnik, K, Fuzik, T, Novacek, J, Plevka, P. | 登録日 | 2022-09-01 | 公開日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Endosome rupture enables enteroviruses to infect cells. To Be Published
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8AY2
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8AXG
| Crystal structure of Fusobacterium nucleatum fusolisin protease | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Fusolisin, ... | 著者 | Isupov, M.N, Wiener, R, Rouvinski, A, Fahoum, J, Kumar, M, Read, R.J. | 登録日 | 2022-08-31 | 公開日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Crystal structure of Fusobacterium nucleatum fusolisin protease To Be Published
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7TXT
| Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl | 分子名称: | 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine, 15B8 Fab heavy chain, 15B8 Fab light chain, ... | 著者 | Singh, I, Seth, A, Billesboelle, C.B, Braz, J, Rodriguiz, R.M, Roy, K, Bekele, B, Craik, V, Huang, X.P, Boytsov, D, Lak, P, O'Donnell, H, Sandtner, W, Roth, B.L, Basbaum, A.I, Wetsel, W.C, Manglik, A, Shoichet, B.K, Rudnick, G. | 登録日 | 2022-02-09 | 公開日 | 2023-03-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure-based discovery of conformationally selective inhibitors of the serotonin transporter. Cell, 186, 2023
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6P49
| Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl2 | 分子名称: | Anoctamin-6, CALCIUM ION | 著者 | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | 登録日 | 2019-05-26 | 公開日 | 2019-07-24 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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6P4Q
| Salmonella typhi PltB Homopentamer N29K Mutant with Neu5Ac-alpha-2-3-Gal-beta-1-4-GlcNAc Glycans | 分子名称: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Putative pertussis-like toxin subunit | 著者 | Nguyen, T, Milano, S.K, Hillpot, E.C, Yang, Y.A, Song, J. | 登録日 | 2019-05-28 | 公開日 | 2020-03-25 | 最終更新日 | 2020-08-05 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence. Cell Host Microbe, 27, 2020
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5U16
| Structure of human MR1-2-OH-1-NA in complex with human MAIT A-F7 TCR | 分子名称: | 2-hydroxynaphthalene-1-carbaldehyde, Beta-2-microglobulin, CHLORIDE ION, ... | 著者 | Keller, A.N, Birkinshaw, R.W, Rossjohn, J. | 登録日 | 2016-11-27 | 公開日 | 2017-02-15 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nat. Immunol., 18, 2017
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4GCI
| Crystal structure of glutahtione s-transferase homolog from yersinia pestis, target EFI-501894, with bound glutathione, monoclinic form | 分子名称: | CHLORIDE ION, GLUTATHIONE, Glutathione S-transferase | 著者 | Vetting, M.W, Toro, R, Bhosle, R, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Armstrong, R.N, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2012-07-30 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of glutahtione s-transferase homolog from yersinia pestis, target EFI-501894, with bound glutathione, monoclinic form To be Published
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6PCS
| E. coli 50S ribosome bound to compound 40e | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl [4-(trifluoromethyl)phenyl]carbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6P6Q
| HCV NS3/4A protease domain of genotype 1a3a chimera in complex with grazoprevir | 分子名称: | (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-di oxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadec ino[11,12-b]quinoxaline-8-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Non-structural protein 4A,Serine protease NS3, ... | 著者 | Timm, J, Schiffer, C.A. | 登録日 | 2019-06-04 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences To Be Published
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6P6Z
| HCV NS3/4A protease domain of genotype 4a with an extended linker in complex with glecaprevir | 分子名称: | (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclop ropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17, 3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide, Non-structural protein 4A,Serine protease NS3, ... | 著者 | Timm, J, Schiffer, C.A. | 登録日 | 2019-06-04 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.294 Å) | 主引用文献 | Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences To Be Published
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5U7C
| Crystal structure of the lead-bound form of MerB formed from diethyllead. | 分子名称: | ACETATE ION, Alkylmercury lyase, BROMIDE ION, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-12 | 公開日 | 2017-01-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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4NFU
| Structure of the central plant immunity signaling node EDS1 in complex with its interaction partner SAG101 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, EDS1, ISOPROPYL ALCOHOL, ... | 著者 | Wagner, S, Stuttmann, J, Rietz, S, Guerois, R, Niefind, K, Parker, J.E. | 登録日 | 2013-11-01 | 公開日 | 2013-12-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity. Cell Host Microbe, 14, 2013
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5U82
| Crystal structure of a MerB-triethyltin complex | 分子名称: | ACETATE ION, Alkylmercury lyase, BROMIDE ION, ... | 著者 | Wahba, H.M, Stevenson, M, Mansour, A, Sygusch, J, Wilcox, D.E, Omichinski, J.G. | 登録日 | 2016-12-13 | 公開日 | 2017-01-11 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage. J. Am. Chem. Soc., 139, 2017
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8AMR
| Coiled-coil domain of human TRIM3 | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Tripartite motif-containing protein 3 | 著者 | Perez-Borrajero, C, Murciano, B, Hennig, J. | 登録日 | 2022-08-04 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural and biophysical studies of TRIM2 and TRIM3 To Be Published
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5UD2
| Class II fructose-1,6-bisphosphate aldolase H180Q variant of Helicobacter pylori with DHAP | 分子名称: | 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase, SODIUM ION, ... | 著者 | Jacques, B, Sygusch, J. | 登録日 | 2016-12-23 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.775 Å) | 主引用文献 | Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. J. Biol. Chem., 293, 2018
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6PII
| The evolving story of AtzT, a periplasmic binding protein | 分子名称: | Atrazine periplasmic binding protein, CALCIUM ION, ETHYL MERCURY ION, ... | 著者 | Peat, T.S, Newman, J, Scott, C, Esquirol, L, Dennis, M, Nebl, T. | 登録日 | 2019-06-26 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | The evolving story of AtzT, a periplasmic binding protein. Acta Crystallogr D Struct Biol, 75, 2019
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4G2U
| Crystal Structure Analysis of Ostertagia ostertagi ASP-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ancylostoma-secreted protein-like protein, SULFATE ION | 著者 | Weeks, S.D, Borloo, J, Geldhof, P, Vercruysse, J, Strelkov, S.V. | 登録日 | 2012-07-13 | 公開日 | 2013-03-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of Ostertagia ostertagi ASP-1: insights into disulfide-mediated cyclization and dimerization Acta Crystallogr.,Sect.D, 69, 2013
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