3WEH
| Crystal structure of the human squalene synthase in complex with presqualene pyrophosphate | 分子名称: | MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | 登録日 | 2013-07-07 | 公開日 | 2014-02-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase. Acta Crystallogr.,Sect.D, 70, 2014
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3T0G
| IspH:HMBPP (substrate) structure of the T167C mutant | 分子名称: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER | 著者 | Span, I, Graewert, T, Bacher, A, Eisenreich, W, Groll, M. | 登録日 | 2011-07-20 | 公開日 | 2011-11-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis. J.Mol.Biol., 416, 2012
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3T0F
| IspH:HMBPP (substrate) structure of the E126D mutant | 分子名称: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER | 著者 | Span, I, Graewert, T, Bacher, A, Eisenreich, W, Groll, M. | 登録日 | 2011-07-20 | 公開日 | 2011-11-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis. J.Mol.Biol., 416, 2012
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3T3N
| Molecular basis for the recognition and cleavage of RNA (UUCCGU) by the bifunctional 5'-3' exo/endoribonuclease RNase J | 分子名称: | Metal dependent hydrolase, O2'methyl-RNA, ZINC ION | 著者 | Dorleans, A, Li de la Sierra-Gallay, I, Piton, J, Zig, L, Gilet, L, Putzer, H, Condon, C. | 登録日 | 2011-07-25 | 公開日 | 2011-10-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Molecular Basis for the Recognition and Cleavage of RNA by the Bifunctional 5'-3' Exo/Endoribonuclease RNase J. Structure, 19, 2011
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4AOF
| Selective small molecule inhibitor discovered by chemoproteomic assay platform reveals regulation of Th17 cell differentiation by PI3Kgamma | 分子名称: | N-[6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]ethanamide, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM | 著者 | Bergamini, G, Bell, K, Shimamura, S, Werner, T, Cansfield, A, Muller, K, Perrin, J, Rau, C, Ellard, K, Hopf, C, Doce, C, Leggate, D, Mangano, R, Mathieson, T, OMahony, A, Plavec, I, Rharbaoui, F, Reinhard, F, Savitski, M.M, Ramsden, N, Hirsch, E, Drewes, G, Rausch, O, Bantscheff, M, Neubauer, G. | 登録日 | 2012-03-26 | 公開日 | 2012-05-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A Selective Inhibitor Reveals Pi3Kgamma Dependence of T(H)17 Cell Differentiation. Nat.Chem.Biol., 8, 2012
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4JAU
| Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase | 著者 | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | 登録日 | 2013-02-19 | 公開日 | 2013-09-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
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4AIX
| Crystallographic structure of an amyloidogenic variant, 3rC34Y, of the germinal line lambda 3 | 分子名称: | IG LAMBDA CHAIN V-IV REGION BAU | 著者 | Villalba, M.I, Luna, O.D, Rudino-Pinera, E, Sanchez, R, Sanchez-Lopez, R, Rojas-Trejo, S, Olamendi-Portugal, T, Fernandez-Velasco, D.A, Becerril, B. | 登録日 | 2012-02-15 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Site-Directed Mutagenesis Reveals Regions Implicated in the Stability and Fiber Formation of Human Lambda3R Light Chains. J.Biol.Chem., 290, 2015
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4JG3
| Crystal structure of catabolite repression control protein (crc) from Pseudomonas aeruginosa | 分子名称: | CHLORIDE ION, Catabolite repression control protein | 著者 | Grishkovskaya, I, Milojevic, T, Sonnleitner, E, Blaesi, U, Djinovic-Carugo, K. | 登録日 | 2013-02-28 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Pseudomonas aeruginosa Catabolite Repression Control Protein Crc Is Devoid of RNA Binding Activity Plos One, 8, 2013
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4JHP
| The crystal structure of the RPGR RCC1-like domain in complex with PDE6D | 分子名称: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, X-linked retinitis pigmentosa GTPase regulator | 著者 | Waetzlich, D, Vetter, I, Wittinghofer, A, Ismail, S. | 登録日 | 2013-03-05 | 公開日 | 2013-04-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo. Embo Rep., 14, 2013
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4AR2
| Dodecahedron formed of penton base protein from adenovirus Ad3 | 分子名称: | CALCIUM ION, FIBER PROTEIN, L2 PROTEIN III (PENTON BASE) | 著者 | Burmeister, W.P, Szolajska, E, Zochowska, M, Nerlo, B, Andreev, I, Schoehn, G, Andrieu, J.-P, Fender, P, Naskalska, A, Zubieta, C, Cusack, S, Chroboczek, J. | 登録日 | 2012-04-20 | 公開日 | 2012-10-24 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | The Structural Basis for the Integrity of Adenovirus Ad3 Dodecahedron. Plos One, 7, 2012
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4JBN
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4A1M
| NMR Structure of protoporphyrin-IX bound murine p22HBP | 分子名称: | HEME-BINDING PROTEIN 1 | 著者 | Goodfellow, B.J, Dias, J.S, Macedo, A.L, Ferreira, G.C, Peterson, F.C, Volkman, B.F, Duarte, I.C.N. | 登録日 | 2011-09-15 | 公開日 | 2011-10-05 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | The NMR Structure of Protoporphyrin-Ix Bound Murine P22Hbp To be Published
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3QHF
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3QJC
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3QN8
| HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor | 分子名称: | (4aS,7aS)-1,4-bis(3-hydroxybenzyl)hexahydro-1H-pyrrolo[3,4-b]pyrazine-2,3-dione, CHLORIDE ION, Protease | 著者 | Lindemann, I, Heine, A, Klebe, G. | 登録日 | 2011-02-08 | 公開日 | 2012-02-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.382 Å) | 主引用文献 | Novel inhibitors for HIV-1 protease To be Published
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4JX7
| Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one | 分子名称: | 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one, PIM1 consensus peptide, Serine/threonine-protein kinase pim-1 | 著者 | Lee, S.J, Han, B.G, Cho, J.W, Choi, J.S, Lee, J.K, Song, H.J, Koh, J.S, Lee, B.I. | 登録日 | 2013-03-27 | 公開日 | 2013-08-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode. Plos One, 8, 2013
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3QFG
| Structure of a putative lipoprotein from Staphylococcus aureus subsp. aureus NCTC 8325 | 分子名称: | Uncharacterized protein | 著者 | Filippova, E.V, Halavaty, A, Shuvalova, L, Minasov, G, Dubrovska, I, Winsor, J, Kiryukhina, O, Papazisi, L, Bagnoli, F, Falugi, F, Bottomley, M, Grandi, G, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-01-21 | 公開日 | 2011-02-02 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Structure of a putative lipoprotein from Staphylococcus aureus subsp. aureus NCTC 8325 To be Published
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3Q7C
| Exonuclease domain of Lassa virus nucleoprotein bound to manganese | 分子名称: | MANGANESE (II) ION, Nucleoprotein, PHOSPHATE ION, ... | 著者 | Hastie, K.M, Kimberlin, C.R, Zandonatti, M.A, MacRae, I.J, Saphire, E.O. | 登録日 | 2011-01-04 | 公開日 | 2011-02-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proc.Natl.Acad.Sci.USA, 108, 2011
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4IKI
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3QJB
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4IFR
| 2.40 Angstroms X-ray crystal structure of R239A 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase from Pseudomonas fluorescens | 分子名称: | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION | 著者 | Huo, L, Davis, I, Chen, L, Liu, A. | 登録日 | 2012-12-14 | 公開日 | 2013-09-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.391 Å) | 主引用文献 | The power of two: arginine 51 and arginine 239* from a neighboring subunit are essential for catalysis in alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase. J.Biol.Chem., 288, 2013
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3WEI
| Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene pyrophosphate | 分子名称: | MANGANESE (II) ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | 登録日 | 2013-07-07 | 公開日 | 2014-02-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase. Acta Crystallogr.,Sect.D, 70, 2014
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3I1G
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3WGL
| STAPHYLOCOCCUS AUREUS FTSZ T7 mutant substituted for GAN bound with GDP, DeltaT7GAN-GDP | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Han, X, Matsui, T, Yu, J, Tanaka, I, Yao, M. | 登録日 | 2013-08-06 | 公開日 | 2013-12-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.066 Å) | 主引用文献 | Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop J.Biol.Chem., 289, 2014
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3QP0
| HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor | 分子名称: | (4aS,7aS)-1,4-bis[3-(hydroxymethyl)benzyl]hexahydro-1H-pyrrolo[3,4-b]pyrazine-2,3-dione, CHLORIDE ION, Protease | 著者 | Lindemann, I, Heine, A, Klebe, G. | 登録日 | 2011-02-11 | 公開日 | 2012-02-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Novel inhibitors for HIV-1 protease To be Published
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