1W34
| FERREDOXIN-NADP REDUCTASE (MUTATION: Y 303 S) | 分子名称: | FERREDOXIN-NADP REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | 著者 | Hermoso, J.A, Perez-Dorado, I, Medina, M, Julvez, M.M, Sanz-Aparicio, J, Gomez-Moreno, C. | 登録日 | 2004-07-13 | 公開日 | 2005-10-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | C-Terminal Tyrosine of Ferredoxin-Nadp(+) Reductase in Hydride Transfer Processes with Nad(P)(+)/H. Biochemistry, 44, 2005
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1W52
| Crystal structure of a proteolyzed form of pancreatic lipase related protein 2 from horse | 分子名称: | CALCIUM ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, PANCREATIC LIPASE RELATED PROTEIN 2 | 著者 | Mancheno, J.M, Jayne, S, Kerfelec, B, Chapus, C, Crenon, I, Hermoso, J.A. | 登録日 | 2004-08-04 | 公開日 | 2006-07-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Crystalization of a Proteolyzed Form of the Horse Pancreatic Lipase-Related Protein 2: Structural Basis for the Specific Detergent Requirement. Acta Crystallogr.,Sect.D, 60, 2004
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2CMN
| A Proximal Arginine Residue in the Switching Mechanism of the FixL Oxygen Sensor | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, SENSOR PROTEIN FIXL | 著者 | Gilles-Gonzalez, M.-A, Caceres, A.I, Silva Sousa, E.H, Tomchick, D.R, Brautigam, C.A, Gonzalez, C, Machius, M. | 登録日 | 2006-05-11 | 公開日 | 2007-05-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Proximal Arginine R206 Participates in Switching of the Bradyrhizobium Japonicum Fixl Oxygen Sensor J.Mol.Biol., 360, 2006
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5WEM
| GluA2 bound to GSG1L in digitonin, state 1 | 分子名称: | Chimera of Glutamate receptor 2,Germ cell-specific gene 1-like protein | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2017-07-10 | 公開日 | 2017-08-02 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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2OPC
| Structure of Melampsora lini avirulence protein, AvrL567-A | 分子名称: | AvrL567-A, COBALT (II) ION, IMIDAZOLE | 著者 | Guncar, G, Wang, C.I, Forwood, J.K, Teh, T, Catanzariti, A.M, Ellis, J.G, Dodds, P.N, Kobe, B. | 登録日 | 2007-01-29 | 公開日 | 2007-03-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | The use of Co2+ for crystallization and structure determination, using a conventional monochromatic X-ray source, of flax rust avirulence protein. Acta Crystallogr.,Sect.F, 63, 2007
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1WAC
| Back-priming mode of Phi6 RNA-dependent RNA polymerase | 分子名称: | P2 PROTEIN | 著者 | Laurila, M.R.L, Salgado, P.S, Stuart, D.I, Grimes, J.M, Bamford, D.H. | 登録日 | 2004-10-26 | 公開日 | 2005-01-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Back-Priming Mode of Phi6 RNA-Dependent RNA Polymerase J.Gen.Virol., 86, 2005
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5WTF
| Cryo-EM structure for Hepatitis A virus empty particle | 分子名称: | VP0, VP1, VP3 | 著者 | Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Walter, T.S, Wang, J, Fry, E.E, Stuart, D.I, Rao, Z. | 登録日 | 2016-12-11 | 公開日 | 2017-01-25 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1W28
| Conformational flexibility of the C-terminus with implications for substrate binding and catalysis in a new crystal form of deacetoxycephalosporin C synthase | 分子名称: | DEACETOXYCEPHALOSPORIN C SYNTHASE | 著者 | Oster, L.M, Terwisscha Van Scheltinga, A.C, Valegard, K, Mackenzie Hose, A, Dubus, A, Hajdu, J, Andersson, I. | 登録日 | 2004-06-30 | 公開日 | 2004-09-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Conformational Flexibility of the C Terminus with Implications for Substrate Binding and Catalysis Revealed in a New Crystal Form of Deacetoxycephalosporin C Synthase J.Mol.Biol., 343, 2004
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2CNV
| SAICAR-synthase from Saccharomyces cerevisiae complexed SAICAR | 分子名称: | ASPARTIC ACID, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID, PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE, ... | 著者 | Urusova, D.V, Antonyuk, S.V, Grebenko, A.I, Levdikov, V.M, Barynin, V.V, Popov, A.N, Lamzin, V.S, Melik-Adamyan, V.R. | 登録日 | 2006-05-24 | 公開日 | 2006-06-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | X-Ray Diffraction Study of the Complex of the Enzyme Saicar Synthase with the Reaction Product Crystallogr.Rep.(Transl. Kristallografiya), 51, 2006
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4CRC
| Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design | 分子名称: | (2S)-2-[[(E)-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-phenyl-N-[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]propanamide, COAGULATION FACTOR XI, SULFATE ION | 著者 | Sandmark, J, Oster, L, Fjellstrom, O, Akkaya, S, Beisel, H.G, Eriksson, P.O, Erixon, K, Gustafsson, D, Jurva, U, Kang, D, Karis, D, Knecht, W, Nerme, V, Nilsson, I, Olsson, T, Redzic, A, Roth, R, Tigerstrom, A. | 登録日 | 2014-02-26 | 公開日 | 2015-02-11 | 最終更新日 | 2015-08-19 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design. Plos One, 10, 2015
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3SRF
| Human M1 pyruvate kinase | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2011-07-07 | 公開日 | 2012-08-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.845 Å) | 主引用文献 | Allosetric regulation of M2 pyruvate kinase. To be Published
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4ZZK
| Crystal structure of truncated FlgD (monoclinic form) from the human pathogen Helicobacter pylori | 分子名称: | Basal-body rod modification protein FlgD | 著者 | Pulic, I, Cendron, L, Salamina, M, Matkovic-Calogovic, D, Zanotti, G. | 登録日 | 2015-05-22 | 公開日 | 2016-02-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of truncated FlgD from the human pathogen Helicobacter pylori. J.Struct.Biol., 194, 2016
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4CN4
| GlgE isoform 1 from Streptomyces coelicolor E423A mutant with 2-deoxy- 2-fluoro-beta-maltosyl modification | 分子名称: | ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE 1, alpha-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-beta-D-glucopyranose | 著者 | Syson, K, Stevenson, C.E.M, Rashid, A.M, Saalbach, G, Tang, M, Tuukanen, A, Svergun, D.I, Withers, S.G, Lawson, D.M, Bornemann, S. | 登録日 | 2014-01-21 | 公開日 | 2014-05-21 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Insight Into How Streptomyces Coelicolor Maltosyl Transferase Glge Binds Alpha-Maltose 1-Phosphate and Forms a Maltosyl-Enzyme Intermediate. Biochemistry, 53, 2014
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1JYR
| Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide | 分子名称: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN | 著者 | Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. | 登録日 | 2001-09-13 | 公開日 | 2002-03-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
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4CRA
| Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design | 分子名称: | COAGULATION FACTOR XI, GLYCEROL, N-[(1S)-2-[(2-amino-5-quinolyl)methylamino]-1-benzyl-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide, ... | 著者 | Sandmark, J, Oster, L, Fjellstrom, O, Akkaya, S, Beisel, H.G, Eriksson, P.O, Erixon, K, Gustafsson, D, Jurva, U, Kang, D, Karis, D, Knecht, W, Nerme, V, Nilsson, I, Olsson, T, Redzic, A, Roth, R, Tigerstrom, A. | 登録日 | 2014-02-26 | 公開日 | 2015-02-11 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design. Plos One, 10, 2015
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4CRD
| Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design | 分子名称: | COAGULATION FACTOR XI, Methyl N-[4-[5-chloro-2-[[3-[5-chloro-2-(tetrazol-1-yl)phenyl]propanoylamino]methyl]-1H-imidazol-4-yl]phenyl]carbamate, SULFATE ION | 著者 | Sandmark, J, Oster, L, Fjellstrom, O, Akkaya, S, Beisel, H.G, Eriksson, P.O, Erixon, K, Gustafsson, D, Jurva, U, Kang, D, Karis, D, Knecht, W, Nerme, V, Nilsson, I, Olsson, T, Redzic, A, Roth, R, Tigerstrom, A. | 登録日 | 2014-02-26 | 公開日 | 2015-02-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design. Plos One, 10, 2015
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5UXQ
| Structure of anti-HIV trimer apex antibody PGT143 | 分子名称: | PGT143 Fab Heavy Chain, PGT143 Fab Light Chain | 著者 | Kong, L, Wilson, I.A. | 登録日 | 2017-02-23 | 公開日 | 2017-04-19 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.415 Å) | 主引用文献 | A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic Beta-Hairpin Structure Immunity, 46, 2017
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5UY3
| Crystal structure of human Fab PGT144, a broadly reactive and potent HIV-1 neutralizing antibody | 分子名称: | Antibody PGT144 Fab heavy chain, Antibody PGT144 Fab light chain | 著者 | Julien, J.-P, Lee, J.H, Wilson, I.A. | 登録日 | 2017-02-23 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure. Immunity, 46, 2017
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1K1T
| Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance | 分子名称: | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN, SULFATE ION | 著者 | Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, Harrison, R.W, Weber, I.T. | 登録日 | 2001-09-25 | 公開日 | 2002-07-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Combining mutations in HIV-1 protease to understand mechanisms of resistance. Proteins, 48, 2002
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2OP6
| Peptide-binding domain of Heat shock 70 kDa protein D precursor from C.elegans | 分子名称: | Heat shock 70 kDa protein D | 著者 | Osipiuk, J, Duggan, E, Gu, M, Voisine, C, Morimoto, R.I, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2007-01-26 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | X-ray structure of peptide-binding domain of Heat shock 70 kDa protein D precursor from C.elegans To be Published
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5WLZ
| Crystal Structure of Amino Acids 1677-1758 of Human Beta Cardiac Myosin Fused to Xrcc4 | 分子名称: | DNA repair protein XRCC4,Myosin-7 | 著者 | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | 登録日 | 2017-07-28 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
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3K21
| Crystal Structure of carboxy-terminus of PFC0420w. | 分子名称: | ACETATE ION, CALCIUM ION, Calcium-dependent protein kinase 3, ... | 著者 | Wernimont, A.K, Hutchinson, A, Artz, J.D, Mackenzie, F, Cossar, D, Kozieradzki, I, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-29 | 公開日 | 2010-01-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Structures of parasitic CDPK domains point to a common mechanism of activation. Proteins, 79, 2011
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2CBM
| Crystal structure of the apo-form of a neocarzinostatin mutant evolved to bind testosterone. | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NEOCARZINOSTATIN | 著者 | Drevelle, A, Graille, M, Heyd, B, Sorel, I, Ulryck, N, Pecorari, F, Desmadril, M, Van Tilbeurgh, H, Minard, P. | 登録日 | 2006-01-06 | 公開日 | 2006-03-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structures of in Vitro Evolved Binding Sites on Neocarzinostatin Scaffold Reveal Unanticipated Evolutionary Pathways. J.Mol.Biol., 358, 2006
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3C7L
| Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation | 分子名称: | Regulator of G-protein signaling 16 | 著者 | Slep, K.C, Kercher, M.A, Wieland, T, Chen, C, Simon, M.I, Sigler, P.B. | 登録日 | 2008-02-07 | 公開日 | 2008-05-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5AK0
| Human PFKFB3 in complex with an indole inhibitor 6 | 分子名称: | (2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE, 6-O-phosphono-beta-D-fructofuranose, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, ... | 著者 | Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J. | 登録日 | 2015-02-27 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3. J.Med.Chem., 58, 2015
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