2CBM

Crystal structure of the apo-form of a neocarzinostatin mutant evolved to bind testosterone.

Summary for 2CBM

Entry DOI	10.2210/pdb2cbm/pdb
Related	1J5H 1J5I 1KVH 1MP7 1NCO 1NOA 1O5P 2CBO 2CBQ 2CBT
Descriptor	NEOCARZINOSTATIN, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	antibiotic, antimicrobial, dna-binding, phage-display
Biological source	STREPTOMYCES CARZINOSTATICUS
Total number of polymer chains	1
Total formula weight	11420.40
Authors	Drevelle, A.,Graille, M.,Heyd, B.,Sorel, I.,Ulryck, N.,Pecorari, F.,Desmadril, M.,Van Tilbeurgh, H.,Minard, P. (deposition date: 2006-01-06, release date: 2006-03-22, Last modification date: 2023-12-13)
Primary citation	Drevelle, A.,Graille, M.,Heyd, B.,Sorel, I.,Ulryck, N.,Pecorari, F.,Desmadril, M.,Van Tilbeurgh, H.,Minard, P. Structures of in Vitro Evolved Binding Sites on Neocarzinostatin Scaffold Reveal Unanticipated Evolutionary Pathways. J.Mol.Biol., 358:455-, 2006 Cited by PubMed: 16529771 DOI: 10.1016/J.JMB.2006.02.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation