2CBM
Crystal structure of the apo-form of a neocarzinostatin mutant evolved to bind testosterone.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NEOCARZINOSTATIN | polymer | 112 | 11225.2 | 1 | UniProt (P0A3R9) Pfam (PF00960) | STREPTOMYCES CARZINOSTATICUS | NCS, MITOMALCIN, MMC |
| 2 | B (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 3 | C (A) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A: 1 - 112 (UniProt: P0A3R9)
| PDB | External Database | Details |
|---|---|---|
| Trp 33 | Asp 67 | engineered mutation |
| Ala 35 | Gly 69 | engineered mutation |
| Trp 37 | Cys 71 | engineered mutation |
| Arg 39 | Trp 73 | engineered mutation |
| Trp 45 | Leu 79 | engineered mutation |
| Tyr 47 | Cys 81 | engineered mutation |
| Asn 52 | Phe 86 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11225.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 195.2 | |
| All* | Total formula weight | 11420.4 |
