1EVE
 
 | | THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE | | 分子名称: | 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kryger, G, Silman, I, Sussman, J.L. | | 登録日 | 1998-03-04 | | 公開日 | 1999-01-20 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Structure Fold.Des., 7, 1999
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5OA8
 | | Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AsqJ_V72I mutant in complex with demethylated cyclopeptin (1d) | | 分子名称: | 2-OXOGLUTARIC ACID, Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, NICKEL (II) ION, ... | | 著者 | Groll, M, Braeuer, A, Kaila, V.R.I. | | 登録日 | 2017-06-21 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ.
Nat Commun, 9, 2018
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5OBV
 | | Mycoplasma genitalium DnaK deletion mutant lacking SBDalpha in complex with ADP and Pi. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein DnaK, PHOSPHATE ION | | 著者 | Adell, M, Calisto, B, Fita, I, Martinelli, L. | | 登録日 | 2017-06-29 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone.
Protein Sci., 27, 2018
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5OHX
 | | Structure of active cystathionine B-synthase from Apis mellifera | | 分子名称: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Gimenez-Mascarell, P, Majtan, T, Oyenarte, I, Ereno-Orbea, J, Majtan, J, Kraus, J.P, Klaudiny, J, Martinez-Cruz, L.A. | | 登録日 | 2017-07-18 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of cystathionine beta-synthase from honeybee Apis mellifera.
J. Struct. Biol., 202, 2018
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1DSK
 | | NMR SOLUTION STRUCTURE OF VPR59_86, 20 STRUCTURES | | 分子名称: | VPR PROTEIN | | 著者 | Yao, S, Torres, A.M, Azad, A.A, Macreadie, I.G, Norton, R.S. | | 登録日 | 1997-10-23 | | 公開日 | 1998-07-01 | | 最終更新日 | 2024-04-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of peptides from HIV-1 Vpr protein that cause membrane permeabilization and growth arrest.
J. Pept. Sci., 4, 1998
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5O2O
 | | Lytic transglycosylase in action | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transglycosylase | | 著者 | Williams, A.H, Hoauz, A, Boneca, I.G. | | 登録日 | 2017-05-22 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Lytic transglycosylase in action
To Be Published
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4ZV5
 | | Crystal structure of N-myristoylated mouse mammary tumor virus matrix protein | | 分子名称: | MYRISTIC ACID, Matrix protein p10 | | 著者 | Zabransky, A, Dolezal, M, Dostal, J, Vanek, O, Hadravova, R, Stokrova, J, Brynda, J, Pichova, I. | | 登録日 | 2015-05-18 | | 公開日 | 2016-01-27 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus.
Retrovirology, 13, 2016
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3S9Z
 | | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-bromophenyl)-2,4-dioxobutanoic acid inhibitor | | 分子名称: | 4-(2-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | | 著者 | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | | 登録日 | 2011-06-02 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.793 Å) | | 主引用文献 | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
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5O24
 | | Lytic transglycosylase in action | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Transglycosylase | | 著者 | Williams, A.H, Hoauz, A, Boneca, I.G. | | 登録日 | 2017-05-19 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.429 Å) | | 主引用文献 | A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
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3S9I
 | | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor | | 分子名称: | 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MAGNESIUM ION, Malate synthase G | | 著者 | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | | 登録日 | 2011-06-01 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
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1DWS
 | | PHOTOLYZED CARBONMONOXY MYOGLOBIN (HORSE HEART) | | 分子名称: | CARBON MONOXIDE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Chu, K, Vojtechovsky, J, McMahon, B.H, Sweet, R.M, Berendzen, J, Schlichting, I. | | 登録日 | 1999-12-11 | | 公開日 | 2000-03-03 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystal Structure of a New Ligand Binding Intermediate in Wildtype Carbonmonoxy Myoglobin
Nature, 403, 2000
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5O5B
 | | Poliovirus type 3 (strain Saukett) stabilized virus-like particle | | 分子名称: | Capsid proteins, VP1, VP2, ... | | 著者 | Bahar, M.W, Kotecha, A, Fry, E.E, Stuart, D.I. | | 登録日 | 2017-06-01 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.
Nat Commun, 8, 2017
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1E2S
 | | Crystal structure of an Arylsulfatase A mutant C69A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Arylsulfatase A, MAGNESIUM ION, ... | | 著者 | von Buelow, R, Schmidt, B, Dierks, T, von Figura, K, Uson, I. | | 登録日 | 2000-05-24 | | 公開日 | 2000-12-06 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.
J. Mol. Biol., 305, 2001
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2MZ2
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3SGK
 | | Unique carbohydrate/carbohydrate interactions are required for high affinity binding of FcgIII and antibodies lacking core fucose | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)][2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment, ... | | 著者 | Ferrara, C, Grau, S, Jaeger, C, Sondermann, P, Bruenker, P, Waldhauer, I, Hennig, M, Ruf, A, Rufer, A.C, Stihle, M, Umana, P, Benz, J. | | 登録日 | 2011-06-15 | | 公開日 | 2011-08-03 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.
Proc.Natl.Acad.Sci.USA, 108, 2011
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1E3C
 | | Crystal structure of an Arylsulfatase A mutant C69S soaked in synthetic substrate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Arylsulfatase A, MAGNESIUM ION | | 著者 | von Buelow, R, Schmidt, B, Dierks, T, von Figura, K, Uson, I. | | 登録日 | 2000-06-13 | | 公開日 | 2001-03-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.
J. Mol. Biol., 305, 2001
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2UYA
 | | DEL162-163 mutant of Bacillus subtilis Oxalate Decarboxylase OxdC | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | | 著者 | Just, V.J, Burrell, M.R, Bowater, L, McRobbie, I, Stevenson, C.E.M, Lawson, D.M, Bornemann, S. | | 登録日 | 2007-04-03 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Identity of the Active Site of Oxalate Decarboxylase and the Importance of the Stability of Active-Site Lid Conformations.
Biochem.J., 407, 2007
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2N9Q
 | | Photoswitchable G-quadruplex | | 分子名称: | DNA (5'-D(*GP*GP*(AZW)P*GP*G)-3'), POTASSIUM ION | | 著者 | Thevarpadam, J, Bessi, I, Binas, O, Goncalves, D.P.N, Slavov, C, Jonker, H.R.A, Richter, C, Wachtveitl, J, Schwalbe, H, Heckel, A. | | 登録日 | 2015-12-02 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
Angew.Chem.Int.Ed.Engl., 55, 2016
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5NP5
 | | Abl2 SH3 pTyr116/161 | | 分子名称: | Abelson tyrosine-protein kinase 2, SULFATE ION | | 著者 | Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. | | 登録日 | 2017-04-13 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
J.Biol.Chem., 294, 2019
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2N1D
 | | Solution structure of the MRG15-MRGBP complex | | 分子名称: | MRG/MORF4L-binding protein, Mortality factor 4-like protein 1 | | 著者 | Xie, T, Zmysloski, A.M, Zhang, Y, Radhakrishnan, I. | | 登録日 | 2015-03-27 | | 公開日 | 2015-05-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for Multi-specificity of MRG Domains.
Structure, 23, 2015
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2N34
 | | NMR assignments and solution structure of the JAK interaction region of SOCS5 | | 分子名称: | Suppressor of cytokine signaling 5 | | 著者 | Chandrashekaran, I.R, Mohanty, B, Linossi, E.M, Nicholson, S.E, Babon, J, Norton, R.S, Dagley, L.F, Leung, E.W.W, Murphy, J.M. | | 登録日 | 2015-05-21 | | 公開日 | 2015-07-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5.
Biochemistry, 54, 2015
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2N4Y
 | | Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome | | 分子名称: | DNA_(5'-D(*CP*TP*GP*GP*GP*CP*GP*GP*GP*AP*CP*TP*GP*GP*GP*GP*AP*GP*TP*GP*GP*T)-3') | | 著者 | DeNicola, B, Lech, C.J, Heddi, B, Regmi, S, Frasson, I, Perrone, R, Richter, S.N, Phan, A.T. | | 登録日 | 2015-07-02 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome.
Nucleic Acids Res., 44, 2016
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2UYB
 | | S161A mutant of Bacillus subtilis Oxalate Decarboxylase OxdC | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, MANGANESE (II) ION, ... | | 著者 | Just, V.J, Burrell, M.R, Bowater, L, McRobbie, I, Stevenson, C.E.M, Lawson, D.M, Bornemann, S. | | 登録日 | 2007-04-03 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Identity of the Active Site of Oxalate Decarboxylase and the Importance of the Stability of Active-Site Lid Conformations.
Biochem.J., 407, 2007
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2MTZ
 | | Haddock model of Bacillus subtilis L,D-transpeptidase in complex with a peptidoglycan hexamuropeptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid, Putative L,D-transpeptidase YkuD, intact bacterial peptidoglycan | | 著者 | Schanda, P, Triboulet, S, Laguri, C, Bougault, C, Ayala, I, Callon, M, Arthur, M, Simorre, J. | | 登録日 | 2014-09-02 | | 公開日 | 2015-01-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan.
J.Am.Chem.Soc., 136, 2014
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5M8J
 | | Crystal structure of Eremococcus coleocola manganese transporter mutant H236A | | 分子名称: | Divalent metal cation transporter MntH | | 著者 | Manatschal, C, Ehrnstorfer, I.A, Arnold, F.M, Laederach, J, Dutzler, R. | | 登録日 | 2016-10-29 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.
Nat Commun, 8, 2017
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