1XH8
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1XH6
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-(4-{[4-(2-HYDROXY-5-PIPERIDIN-1-YLBENZOYL)BENZOYL]AMINO}AZEPAN-3-YL)ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
6HP8
| |
1XH4
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
3SHJ
| Proteasome in complex with hydroxyurea derivative HU10 | 分子名称: | 1-hydroxy-1-[(2R)-4-{3-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yloxy]phenyl}but-3-yn-2-yl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proteasome component C1, ... | 著者 | Gallastegui, N, Beck, P, Arciniega, M, Hillebrand, S, Huber, R, Groll, M. | 登録日 | 2011-06-16 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Hydroxyureas as noncovalent proteasome inhibitors. Angew.Chem.Int.Ed.Engl., 51, 2012
|
|
3OKJ
| Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition | 分子名称: | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S,3S)-3-hydroxy-1-(4-hydroxyphenyl)-4-oxobutan-2-yl]-L-leucinamide, Proteasome component C1, Proteasome component C11, ... | 著者 | Groll, M, Poynor, M, Gallastegui, P, Stein, M, Schmidt, B, Kloetzel, P.M, Huber, R. | 登録日 | 2010-08-25 | 公開日 | 2011-06-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition Angew.Chem.Int.Ed.Engl., 50, 2011
|
|
1XH7
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-[4-({4-[5-(3,3-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1STC
| CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE | 分子名称: | CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, STAUROSPORINE | 著者 | Prade, L, Engh, R.A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D. | 登録日 | 1997-10-10 | 公開日 | 1998-02-25 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential. Structure, 5, 1997
|
|
1PIG
| PIG PANCREATIC ALPHA-AMYLASE COMPLEXED WITH THE OLIGOSACCHARIDE V-1532 | 分子名称: | 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ... | 著者 | Machius, M, Vertesy, L, Huber, R, Wiegand, G. | 登録日 | 1996-06-15 | 公開日 | 1996-12-07 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Carbohydrate and protein-based inhibitors of porcine pancreatic alpha-amylase: structure analysis and comparison of their binding characteristics. J.Mol.Biol., 260, 1996
|
|
1AQW
| GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, GLUTATHIONE S-TRANSFERASE | 著者 | Prade, L, Huber, R, Manoharan, T.H, Fahl, W.E, Reuter, W. | 登録日 | 1997-08-03 | 公開日 | 1998-03-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor. Structure, 5, 1997
|
|
1AQX
| GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX | 分子名称: | 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE | 著者 | Prade, L, Huber, R, Manoharan, T.H, Fahl, W.E, Reuter, W. | 登録日 | 1997-08-03 | 公開日 | 1998-03-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor. Structure, 5, 1997
|
|
3RGF
| Crystal Structure of human CDK8/CycC | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Cyclin-C, ... | 著者 | Schneider, E.V, Boettcher, J, Blaesse, M, Huber, R, Maskos, K. | 登録日 | 2011-04-08 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder. J.Mol.Biol., 412, 2011
|
|
1TLE
| LE (LAMININ-TYPE EGF-LIKE) MODULE GIII4 IN SOLUTION AT PH 3.5 AND 290 K, NMR, 14 STRUCTURES | 分子名称: | LAMININ | 著者 | Baumgartner, R, Czisch, M, Mayer, U, Schl, E.P, Huber, R, Timpl, R, Holak, T.A. | 登録日 | 1996-01-26 | 公開日 | 1997-02-12 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the nidogen binding LE module of the laminin gamma1 chain in solution. J.Mol.Biol., 257, 1996
|
|
1PIF
| PIG ALPHA-AMYLASE | 分子名称: | ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION | 著者 | Machius, M, Vertesy, L, Huber, R, Wiegand, G. | 登録日 | 1996-06-15 | 公開日 | 1996-12-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Carbohydrate and protein-based inhibitors of porcine pancreatic alpha-amylase: structure analysis and comparison of their binding characteristics. J.Mol.Biol., 260, 1996
|
|
1HVF
| STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER | 分子名称: | ANNEXIN V, CALCIUM ION, SULFATE ION | 著者 | Burger, A, Huber, R. | 登録日 | 1994-06-29 | 公開日 | 1995-03-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter J.Mol.Biol., 237, 1994
|
|
1HVE
| STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER | 分子名称: | ANNEXIN V, CALCIUM ION, SULFATE ION | 著者 | Burger, A, Huber, R. | 登録日 | 1994-06-29 | 公開日 | 1995-03-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter J.Mol.Biol., 237, 1994
|
|
1HVG
| STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER | 分子名称: | ANNEXIN V | 著者 | Burger, A, Huber, R. | 登録日 | 1994-06-29 | 公開日 | 1995-03-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter J.Mol.Biol., 237, 1994
|
|
1P8J
| CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE INHIBITOR, ... | 著者 | Henrich, S, Cameron, A, Bourenkov, G.P, Kiefersauer, R, Huber, R, Lindberg, I, Bode, W, Than, M.E. | 登録日 | 2003-05-07 | 公開日 | 2003-07-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity Nat.Struct.Biol., 10, 2003
|
|
3HGT
| |
3HGQ
| |
1QA2
| TAILSPIKE PROTEIN, MUTANT A334V | 分子名称: | TAILSPIKE PROTEIN | 著者 | Baxa, U, Steinbacher, S, Weintraub, A, Huber, R, Seckler, R. | 登録日 | 1999-04-10 | 公開日 | 2000-01-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity. J.Mol.Biol., 293, 1999
|
|
3CTS
| |
1QRC
| TAILSPIKE PROTEIN, MUTANT W391A | 分子名称: | TAILSPIKE PROTEIN | 著者 | Schuler, B, Furst, F, Osterroth, F, Steinbacher, S, Huber, R, Seckler, R. | 登録日 | 1999-06-13 | 公開日 | 2000-04-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Plasticity and steric strain in a parallel beta-helix: rational mutations in the P22 tailspike protein. Proteins, 39, 2000
|
|
1QA1
| TAILSPIKE PROTEIN, MUTANT V331G | 分子名称: | TAILSPIKE PROTEIN | 著者 | Baxa, U, Steinbacher, S, Weintraub, A, Huber, R, Seckler, R. | 登録日 | 1999-04-10 | 公開日 | 2000-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity. J.Mol.Biol., 293, 1999
|
|
1QA3
| TAILSPIKE PROTEIN, MUTANT A334I | 分子名称: | TAILSPIKE PROTEIN | 著者 | Baxa, U, Steinbacher, S, Weintraub, A, Huber, R, Seckler, R. | 登録日 | 1999-04-10 | 公開日 | 2000-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity. J.Mol.Biol., 293, 1999
|
|