6R7E
 
 | | N-terminally reversed variant of FimA E. coli with alanine insertion at position 20 | | Descriptor: | FimA, SULFATE ION | | Authors: | Zyla, D, Echeverria, B, Glockshuber, R. | | Deposit date: | 2019-03-28 | | Release date: | 2020-05-06 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA.
J.Biol.Chem., 295, 2020
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6SWH
 | | Crystal structure of the ternary complex between the type 1 pilus proteins FimC, FimI and FimA from E. coli | | Descriptor: | 1,2-ETHANEDIOL, Chaperone protein FimC, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Giese, C, Puorger, C, Ignatov, O, Weber, M, Scharer, M.A, Capitani, G, Glockshuber, R. | | Deposit date: | 2019-09-20 | | Release date: | 2020-10-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Comprehensive kinetic characterization of bacterial pilus rod assembly and assembly termination
To Be Published
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4P05
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5IQN
 | | Crystal structure of the E. coli type 1 pilus subunit FimG (engineered variant with substitution Q134E; N-terminal FimG residues 1-12 truncated) in complex with the donor strand peptide DsF_SRIRIRGYVR | | Descriptor: | 1,2-ETHANEDIOL, COBALT (II) ION, Protein FimF, ... | | Authors: | Giese, C, Eras, J, Kern, A, Scharer, M.A, Capitani, G, Glockshuber, R. | | Deposit date: | 2016-03-11 | | Release date: | 2016-07-06 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Accelerating the Association of the Most Stable Protein-Ligand Complex by More than Two Orders of Magnitude.
Angew.Chem.Int.Ed.Engl., 55, 2016
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6ERJ
 | | Self-complemented FimA subunit from Salmonella enterica | | Descriptor: | ACETIC ACID, Type-1 fimbrial protein, a chain | | Authors: | Zyla, D.S, Prota, A, Capitani, G, Glockshuber, R. | | Deposit date: | 2017-10-18 | | Release date: | 2019-01-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria.
J.Biol.Chem., 294, 2019
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8PIU
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5IQM
 | | Crystal structure of the E. coli type 1 pilus subunit FimG (engineered variant with substitution Q134E; N-terminal FimG residues 1-12 truncated) in complex with the donor strand peptide DsF_T4R-T6R-D13N | | Descriptor: | COBALT (II) ION, Protein FimF, Protein FimG | | Authors: | Giese, C, Eras, J, Kern, A, Scharer, M.A, Capitani, G, Glockshuber, R. | | Deposit date: | 2016-03-11 | | Release date: | 2016-07-06 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Accelerating the Association of the Most Stable Protein-Ligand Complex by More than Two Orders of Magnitude.
Angew.Chem.Int.Ed.Engl., 55, 2016
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4M92
 | | Crystal structure of hN33/Tusc3-peptide 2 | | Descriptor: | Interleukin-1 receptor accessory protein-like 1, Tumor suppressor candidate 3 | | Authors: | Mohorko, E, Owen, R.L, Malojcic, G, Brozzo, M.S, Aebi, M, Glockshuber, R. | | Deposit date: | 2013-08-14 | | Release date: | 2014-03-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural basis of substrate specificity of human oligosaccharyl transferase subunit n33/tusc3 and its role in regulating protein N-glycosylation.
Structure, 22, 2014
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4M91
 | | crystal structure of hN33/Tusc3-peptide 1 | | Descriptor: | Protein cereblon, Tumor suppressor candidate 3 | | Authors: | Mohorko, E, Owen, R.L, Malojcic, G, Brozzo, M.S, Aebi, M, Glockshuber, R. | | Deposit date: | 2013-08-14 | | Release date: | 2014-03-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Structural basis of substrate specificity of human oligosaccharyl transferase subunit n33/tusc3 and its role in regulating protein N-glycosylation.
Structure, 22, 2014
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7B0W
 | | Crystal structure of the E. coli type 1 pilus assembly inhibitor FimI bound to FimC | | Descriptor: | 1,2-ETHANEDIOL, Chaperone protein FimC, FORMIC ACID, ... | | Authors: | Scharer, M.A, Zigova, Z, Giese, C, Puorger, C, Ignatov, O, Capitani, G, Glockshuber, R. | | Deposit date: | 2020-11-23 | | Release date: | 2021-12-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Comprehensive kinetic characterization of bacterial pilus rod assembly and assembly termination
To Be Published
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7B0X
 | | Crystal structure of the ternary complex of the E. coli type 1 pilus proteins FimC, FimI and the N-terminal domain of FimD | | Descriptor: | 1,2-ETHANEDIOL, Chaperone protein FimC, Fimbrin-like protein FimI, ... | | Authors: | Scharer, M.A, Zigova, Z, Giese, C, Puorger, C, Ignatov, O, Capitani, G, Glockshuber, R. | | Deposit date: | 2020-11-23 | | Release date: | 2021-12-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Comprehensive kinetic characterization of bacterial pilus rod assembly and assembly termination
To Be Published
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6ZS5
 | | 3.5 A cryo-EM structure of human uromodulin filament core | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R. | | Deposit date: | 2020-07-15 | | Release date: | 2020-09-02 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
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5IQO
 | | Crystal structure of the E. coli type 1 pilus subunit FimG (engineered variant with substitutions Q134E and S138E; N-terminal FimG residues 1-12 truncated) in complex with the donor strand peptide DsF_T4R-T6R-D13N | | Descriptor: | 1,2-ETHANEDIOL, COBALT (II) ION, PENTAETHYLENE GLYCOL, ... | | Authors: | Giese, C, Eras, J, Kern, A, Capitani, G, Glockshuber, R. | | Deposit date: | 2016-03-11 | | Release date: | 2016-07-06 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.302 Å) | | Cite: | Accelerating the Association of the Most Stable Protein-Ligand Complex by More than Two Orders of Magnitude.
Angew.Chem.Int.Ed.Engl., 55, 2016
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6ZYA
 | | Extended human uromodulin filament core at 3.5 A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R. | | Deposit date: | 2020-07-31 | | Release date: | 2020-09-02 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
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5LP9
 | | FimA wt from S. flexneri | | Descriptor: | Major type 1 subunit fimbrin (Pilin) | | Authors: | Zyla, D, Capitani, G, Prota, A, Glockshuber, R. | | Deposit date: | 2016-08-12 | | Release date: | 2017-12-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (0.88626635 Å) | | Cite: | Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria.
J.Biol.Chem., 2019
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1UN2
 | | Crystal structure of circularly permuted CPDSBA_Q100T99: Preserved Global Fold and Local Structural Adjustments | | Descriptor: | THIOL-DISULFIDE INTERCHANGE PROTEIN | | Authors: | Manjasetty, B.A, Hennecke, J, Glockshuber, R, Heinemann, U. | | Deposit date: | 2003-09-03 | | Release date: | 2003-09-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of Circularly Permuted Dsba(Q100T99): Preserved Global Fold and Local Structural Adjustments
Acta Crystallogr.,Sect.D, 60, 2004
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4TXV
 | | Crystal structure of the mixed disulfide intermediate between thioredoxin-like TlpAs(C110S) and subunit II of cytochrome c oxidase CoxBPD (C233S) | | Descriptor: | Cytochrome c oxidase subunit 2, Thiol:disulfide interchange protein TlpA | | Authors: | Quade, N, Abicht, H.K, Hennecke, H, Glockshuber, R. | | Deposit date: | 2014-07-07 | | Release date: | 2014-10-01 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | How Periplasmic Thioredoxin TlpA Reduces Bacterial Copper Chaperone ScoI and Cytochrome Oxidase Subunit II (CoxB) Prior to Metallation.
J.Biol.Chem., 289, 2014
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4X43
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2WCD
 | | Crystal structure of the assembled cytolysin A pore | | Descriptor: | ETHYL MERCURY ION, HEMOLYSIN E, CHROMOSOMAL | | Authors: | Mueller, M, Grauschopf, U, Maier, T, Glockshuber, R, Ban, N. | | Deposit date: | 2009-03-11 | | Release date: | 2009-05-05 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.29 Å) | | Cite: | The Structure of a Cytolytic Alpha-Helical Toxin Pore Reveals its Assembly Mechanism
Nature, 459, 2009
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1AG2
 | | PRION PROTEIN DOMAIN PRP(121-231) FROM MOUSE, NMR, 2 MINIMIZED AVERAGE STRUCTURE | | Descriptor: | MAJOR PRION PROTEIN | | Authors: | Billeter, M, Riek, R, Wider, G, Wuthrich, K, Hornemann, S, Glockshuber, R. | | Deposit date: | 1997-03-31 | | Release date: | 1997-10-08 | | Last modified: | 2024-06-05 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the mouse prion protein domain PrP(121-231).
Nature, 382, 1996
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1GAM
 | | GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN | | Descriptor: | GAMMA B CRYSTALLIN | | Authors: | Norledge, B.V, Mayr, E.-M, Glockshuber, R, Bateman, O.A, Slingsby, C, Jaenicke, R, Driessen, H.P.C. | | Deposit date: | 1996-02-02 | | Release date: | 1996-07-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins.
Nat.Struct.Biol., 3, 1996
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1DSL
 | | GAMMA B CRYSTALLIN C-TERMINAL DOMAIN | | Descriptor: | GAMMA B CRYSTALLIN | | Authors: | Norledge, B.V, Mayr, E.-M, Glockshuber, R, Bateman, O.A, Slingsby, C, Jaenicke, R, Driessen, H.P.C. | | Deposit date: | 1996-02-01 | | Release date: | 1996-07-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins.
Nat.Struct.Biol., 3, 1996
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4P04
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4P06
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1ZE3
 | | Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH | | Descriptor: | 1,2-ETHANEDIOL, Chaperone protein fimC, FimH protein, ... | | Authors: | Nishiyama, M, Horst, R, Eidam, O, Herrmann, T, Ignatov, O, Vetsch, M, Bettendorff, P, Jelesarov, I, Grutter, M.G, Wuthrich, K, Glockshuber, R, Capitani, G. | | Deposit date: | 2005-04-17 | | Release date: | 2005-06-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD.
Embo J., 24, 2005
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