6J4Q
 
 | | Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications | | 分子名称: | GLYCEROL, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide, Small vasohibin-binding protein, ... | | 著者 | Wang, N, Bao, H, Huang, H. | | 登録日 | 2019-01-10 | | 公開日 | 2019-05-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Nat.Struct.Mol.Biol., 26, 2019
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7VJM
 | | Aca1 in complex with 19bp palindromic DNA substrate | | 分子名称: | DNA (5'-D(*AP*TP*TP*AP*GP*GP*CP*AP*CP*AP*TP*TP*GP*TP*GP*CP*CP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*GP*GP*CP*AP*CP*AP*AP*TP*GP*TP*GP*CP*CP*TP*AP*A)-3'), anti-CRISPR-associated protein Aca1 | | 著者 | Liu, Y.H, Zhang, L.S, Wu, B.X, Huang, H.D. | | 登録日 | 2021-09-28 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.
J.Biol.Chem., 297, 2021
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7VJP
 | | Selenomethionine-derived Pectobacterium phage ZF40 apo-Aca2 | | 分子名称: | SULFATE ION, anti-CRISPR-associated protein Aca2 | | 著者 | Liu, Y.H, Zhang, L.S, Wu, B.X, Huang, H.D. | | 登録日 | 2021-09-28 | | 公開日 | 2021-10-20 | | 最終更新日 | 2022-02-02 | | 実験手法 | X-RAY DIFFRACTION (1.594 Å) | | 主引用文献 | Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.
J.Biol.Chem., 297, 2021
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6M11
 | | Crystal structure of Rnase L in complex with Sunitinib | | 分子名称: | 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, PHOSPHATE ION, ... | | 著者 | Tang, J, Huang, H. | | 登録日 | 2020-02-24 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
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6M13
 | | Crystal structure of Rnase L in complex with Toceranib | | 分子名称: | 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide, PHOSPHATE ION, Ribonuclease L, ... | | 著者 | Tang, J, Huang, H. | | 登録日 | 2020-02-24 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
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4A4S
 | | UNAC Tetraloops: To What Extent Can They Mimic GNRA Tetraloops | | 分子名称: | 5'-R(*GP*GP*AP*CP*CP*CP*GP*GP*CP*UP*CP*AP*CP*GP *CP*UP*GP*GP*GP*UP*CP*C)-3' | | 著者 | Zhao, Q, Huang, H, Nagaswamy, U, Xia, Y, Gao, X, Fox, G. | | 登録日 | 2011-10-20 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Unac Tetraloops: To What Extent Can They Mimic Gnra Tetraloops
Biopolymers, 97, 2012
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4A4U
 | | UNAC Tetraloops: To What Extent Can They Mimic GNRA Tetraloops | | 分子名称: | 5'-R(*GP*GP*AP*CP*CP*CP*GP*GP*CP*UP*GP*AP*CP*GP *CP*UP*GP*GP*GP*UP*CP*C)-3' | | 著者 | Zhao, Q, Huang, H, Nagaswamy, U, Xia, Y, Gao, X, Fox, G. | | 登録日 | 2011-10-20 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Unac Tetraloops: To What Extent Can They Mimic Gnra Tetraloops
Biopolymers, 97, 2012
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6J4P
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6J4U
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6KBU
 | | Crystal structure of yedK | | 分子名称: | GLYCEROL, SOS response-associated protein | | 著者 | Wang, N, Bao, H, Huang, H. | | 登録日 | 2019-06-26 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
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6KIJ
 | | Crystal structure of yedK with ssDNA containing an abasic site | | 分子名称: | DNA (5'-D(*GP*AP*TP*TP*CP*GP*TP*CP*G)-3'), GLYCEROL, PENTANE-3,4-DIOL-5-PHOSPHATE, ... | | 著者 | Wang, N, Bao, H, Huang, H. | | 登録日 | 2019-07-18 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
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6KBX
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6KBS
 | | Crystal structure of yedK in complex with ssDNA | | 分子名称: | DNA (5'-D(*CP*GP*GP*TP*CP*GP*AP*TP*TP*C)-3'), SOS response-associated protein | | 著者 | Wang, N, Bao, H, Huang, H. | | 登録日 | 2019-06-26 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
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6KCQ
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5TVT
 | | Structure of Maternal Embryonic Leucine Zipper Kinase | | 分子名称: | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one, Maternal embryonic leucine zipper kinase | | 著者 | Seo, H.-Y, Huang, H, Gray, N.S, Dhe-Paganon, S. | | 登録日 | 2016-11-10 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structure of Maternal Embryonic Leucine Zipper Kinase
To Be Published
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7VJN
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6M12
 | | Crystal Structure of Rnase L in complex with SU11652 | | 分子名称: | 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, PHOSPHATE ION, Ribonuclease L, ... | | 著者 | Tang, J, Huang, H. | | 登録日 | 2020-02-24 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
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7XFZ
 | | CryoEM structure of type IV-A Csf-crRNAsp14-dsDNA ternary complex | | 分子名称: | Csf1, Csf2, Csf3, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-04-02 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment.
Mol.Cell, 83, 2023
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7XG1
 | | CryoEM structure of type IV-A Csf-crRNA binary complex | | 分子名称: | Csf1, Csf2, Csf3, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-04-02 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment
Mol.Cell, 83, 2023
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7XG2
 | | CryoEM structure of type IV-A NTS-nicked dsDNA bound Csf-crRNA ternary complex | | 分子名称: | Csf1, Csf2, Csf3, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-04-02 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment.
Mol.Cell, 83, 2023
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7XG0
 | | CryoEM structure of type IV-A Csf-crRNA-dsDNA ternary complex | | 分子名称: | Csf1, Csf2, Csf3, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-04-02 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment.
Mol.Cell, 83, 2023
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7XG4
 | | CryoEM structure of type IV-A CasDinG bound NTS-nicked Csf-crRNA-dsDNA quaternary complex in a second state | | 分子名称: | Csf1, Csf2, Csf3, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-04-02 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment.
Mol.Cell, 83, 2023
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7XG3
 | | CryoEM structure of type IV-A CasDinG bound NTS-nicked Csf-crRNA-dsDNA quaternary complex | | 分子名称: | Csf1, Csf2, Csf3, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-04-02 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment.
Mol.Cell, 83, 2023
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7Y84
 | | CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease | | 分子名称: | CHAT domain protein, MAGNESIUM ION, RAMP superfamily protein, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-06-22 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase.
Nat Commun, 13, 2022
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7Y83
 | | CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease bound to non-self RNA target | | 分子名称: | CHAT domain protein, MAGNESIUM ION, RAMP superfamily protein, ... | | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | | 登録日 | 2022-06-22 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase.
Nat Commun, 13, 2022
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