8I8Y
 
 | | A mutant of the C-terminal complex of proteins 4.1G and NuMA | | Descriptor: | Engineered protein | | Authors: | Hu, X. | | Deposit date: | 2023-02-06 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
2RBL
 | |
2RB8
 | |
7YUY
 | | Structure of a mutated membrane-bound glycosyltransferase | | Descriptor: | (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hu, X.L, Yang, P, Zhang, M, Liu, X.T, Yu, H.J. | | Deposit date: | 2022-08-18 | | Release date: | 2023-03-29 | | Last modified: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1.
Nature, 616, 2023
|
|
4H48
 | | 1.45 angstrom CyPet Structure at pH7.0 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Green fluorescent protein | | Authors: | Hu, X.-J, Liu, R. | | Deposit date: | 2012-09-17 | | Release date: | 2013-09-18 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structure insight of the fluorescent state of CyPet
To be Published
|
|
1NHI
 | | Crystal structure of N-terminal 40KD MutL (LN40) complex with ADPnP and one potassium | | Descriptor: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | | Authors: | Hu, X, Machius, M, Yang, W. | | Deposit date: | 2002-12-19 | | Release date: | 2003-06-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
|
|
1NHH
 | | Crystal structure of N-terminal 40KD MutL protein (LN40) complex with ADPnP and one Rubidium | | Descriptor: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | | Authors: | Hu, X, Machius, M, Yang, W. | | Deposit date: | 2002-12-19 | | Release date: | 2003-06-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
|
|
1NHJ
 | | Crystal structure of N-terminal 40KD MutL/A100P mutant protein complex with ADPnP and one sodium | | Descriptor: | DNA mismatch repair protein mutL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Hu, X, Machius, M, Yang, W. | | Deposit date: | 2002-12-19 | | Release date: | 2003-06-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
|
|
8HDU
 | |
8HDV
 | |
5C8Z
 | | ZHD-ZGR complex after ZHD crystal soaking in ZEN for 30min | | Descriptor: | 2,4-dihydroxy-6-[(1E,10S)-10-hydroxy-6-oxoundec-1-en-1-yl]benzoic acid, FORMIC ACID, GLYCEROL, ... | | Authors: | Hu, X.-J, Qi, Q, Yang, W.-J. | | Deposit date: | 2015-06-26 | | Release date: | 2016-06-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The structure of a complex of the lactonohydrolase zearalenone hydrolase with the hydrolysis product of zearalenone at 1.60 angstrom resolution.
Acta Crystallogr F Struct Biol Commun, 73, 2017
|
|
8Y33
 | | A near-infrared fluorescent protein of de novo backbone design | | Descriptor: | 3-[5-[(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-2-[[5-[(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, near-infrared fluorescent protein | | Authors: | Hu, X, Xu, Y. | | Deposit date: | 2024-01-28 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Using Protein Design and Directed Evolution to Monomerize a Bright Near-Infrared Fluorescent Protein.
Acs Synth Biol, 13, 2024
|
|
5JVA
 | | 1.95 angstrom crystal structure of TAGRFP-T | | Descriptor: | BETA-MERCAPTOETHANOL, SULFATE ION, TagRFP-T | | Authors: | Hu, X.J. | | Deposit date: | 2016-05-11 | | Release date: | 2017-05-17 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The crystal structure of red fluorescent protein TagRFP-T reveals the mechanism of its superior photostability.
Biochem. Biophys. Res. Commun., 477, 2016
|
|
8J98
 | | A near-infrared fluorescent protein of de novo backbone design | | Descriptor: | 3-[5-[[(3~{R},4~{R})-3-ethenyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, FORMIC ACID, GLYCEROL, ... | | Authors: | Hu, X, Xu, Y. | | Deposit date: | 2023-05-02 | | Release date: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | De novo backbone design for monomerization of near-infrared fluorescent protein
To Be Published
|
|
8J1X
 | |
8J1W
 | |
5HKE
 | | bile salt hydrolase from Lactobacillus salivarius | | Descriptor: | Bile salt hydrolase, PHOSPHATE ION | | Authors: | Hu, X.-J. | | Deposit date: | 2016-01-14 | | Release date: | 2016-05-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of bile salt hydrolase from Lactobacillus salivarius.
Acta Crystallogr F Struct Biol Commun, 72, 2016
|
|
3I19
 | |
3LA1
 | |
8XQN
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQL
 | | Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQR
 | | Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. | | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQO
 | | Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQT
 | | Structure of human class T GPCR TAS2R14-Gi complex. | | Descriptor: | CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8YKY
 | | Structure of human class T GPCR TAS2R14-Ggustducin complex with agonist 28.1 | | Descriptor: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, G alpha gustducin protein, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-03-05 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
