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PDB: 336 件
1F8W
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CRYSTAL STRUCTURE OF NADH PEROXIDASE MUTANT: R303M
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, NADH PEROXIDASE
著者Yeh, J.I, Claiborne, A, Hol, W.G.J.
登録日2000-07-05
公開日2001-02-05
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Analysis of the kinetic and redox properties of the NADH peroxidase R303M mutant: correlation with the crystal structure.
Biochemistry, 39, 2000
1RCV
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Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1
分子名称: [3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO] -2-(3-{4-[3-(3-NITRO-5-[GALACTOPYRANOSYLOXY]-BENZOYLAMINO)-PROPYL]-PIPERAZIN-1-YL} -PROPYL-AMINO)-3,4-DIOXO-CYCLOBUTENE, cholera toxin B protein (CTB)
著者Pickens, J.C, Mitchell, D.D, Liu, J, Tan, X, Zhang, Z, Verlinde, C.L, Hol, W.G, Fan, E.
登録日2003-11-04
公開日2004-10-26
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chem.Biol., 11, 2004
1RD9
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Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV2
分子名称: 1,3-BIS-([3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYL-AMINO]-CARBONYLOXY)-2-AMINO-PROPANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HEXAETHYLENE GLYCOL, ...
著者Pickens, J.C, Mitchell, D.D, Liu, J, Tan, X, Zhang, Z, Verlinde, C.L, Hol, W.G, Fan, E.
登録日2003-11-05
公開日2004-10-26
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chem.Biol., 11, 2004
1R59
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Enterococcus casseliflavus glycerol kinase
分子名称: Glycerol kinase
著者Yeh, J.I, Charrier, V, Paulo, J, Hou, L, Darbon, E, Claiborne, A, Hol, W.G, Deutscher, J.
登録日2003-10-09
公開日2004-10-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of Enterococcal Glycerol Kinase in the Absence and Presence of Glycerol: Correlation of conformation to substrate binding and a mechanism of activation by phosphorylation
Biochemistry, 43, 2004
1RDP
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Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV3
分子名称: 1,3-BIS-([[3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO-3,4-DIOXO-CYCLOBU TENYL]-AMINO-ETHYL]-AMINO-CARBONYLOXY)-2-AMINO-PROPANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, TRIETHYLENE GLYCOL, ...
著者Pickens, J.C, Mitchell, D.D, Liu, J, Tan, X, Zhang, Z, Verlinde, C.L, Hol, W.G, Fan, E.
登録日2003-11-05
公開日2004-10-26
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chem.Biol., 11, 2004
1TC5
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Structural Analysis of a probable eukaryotic D-amino acid tRNA deacylase
分子名称: Probable eukaryotic D-amino acid tRNA deacylase, LMAJ005534AAA
著者Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-05-20
公開日2004-06-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural analysis of LMAJ005534AAA, a probable eukaryotic D-amino acid tRNA deacylase from Leishmania major
To be Published
1UV7
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periplasmic domain of EpsM from Vibrio cholerae
分子名称: GENERAL SECRETION PATHWAY PROTEIN M
著者Abendroth, J, Hol, W.G.J.
登録日2004-01-15
公開日2004-04-23
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Crystal Structure of the Periplasmic Domain of the Type II Secretion System Protein Epsm from Vibrio Cholerae: The Simplest Version of the Ferredoxin Fold
J.Mol.Biol., 338, 2004
1N1E
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Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase complexed with DHAP and NAD
分子名称: ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE) P'-5'-ESTER WITH 3-(AMINOCARBONYL)-4-(1-HYDROXYL-2-OXO-3-PHOSPHONOOXY-PROPYL)-1-BETA-D-RIBOFURANOSYLPYRIDINIUM INNER SALT, glycerol-3-phosphate dehydrogenase
著者Choe, J, Hol, W.G.J.
登録日2002-10-17
公開日2003-05-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Leishmania mexicana Glycerol-3-phosphate Dehydrogenase Showed Conformational Changes Upon Binding a Bi-substrate Adduct
J.Mol.Biol., 320, 2003
1P9W
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Crystal Structure of Vibrio cholerae putative NTPase EpsE
分子名称: General secretion pathway protein E, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ZINC ION
著者Robien, M.A, Krumm, B.E, Sandkvist, M, Hol, W.G.J.
登録日2003-05-12
公開日2003-10-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the extracellular protein secretion NTPase EpsE of Vibrio cholerae
J.Mol.Biol., 333, 2003
1HTL
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MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
分子名称: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
著者Merritt, E.A, Hol, W.G.J.
登録日1995-02-15
公開日1995-04-20
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nat.Struct.Biol., 2, 1995
1M66
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Crystal Structure of Leishmania mexicana GPDH Complexed with Inhibitor 2-bromo-6-chloro-purine
分子名称: 2-BROMO-6-CHLORO-PURINE, Glycerol-3-phosphate dehydrogenase, PALMITIC ACID
著者Choe, J, Suresh, S, Wisedchaisri, G, Kennedy, K.J, Gelb, M.H, Hol, W.G.J.
登録日2002-07-12
公開日2002-12-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase
Chem.Biol., 9, 2002
1N57
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Crystal Structure of Chaperone Hsp31
分子名称: Chaperone Hsp31, MAGNESIUM ION
著者Quigley, P.M, Korotkov, K, Baneyx, F, Hol, W.G.J.
登録日2002-11-04
公開日2003-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The 1.6A Crystal Structure of the Class of Chaperone Represented by Escherichia coli Hsp31 Reveals a Putative Catalytic Triad
Proc.Natl.Acad.Sci.USA, 100, 2003
1P9R
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Crystal Structure of Vibrio cholerae putative NTPase EpsE
分子名称: CHLORIDE ION, General secretion pathway protein E, ZINC ION
著者Robien, M.A, Krumm, B.E, Sandkvist, M, Hol, W.G.J.
登録日2003-05-12
公開日2003-10-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the extracellular protein secretion NTPase EpsE of Vibrio cholerae
J.Mol.Biol., 333, 2003
1PZK
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Cholera Toxin B-Pentamer Complexed With N-Acyl Phenyl Galactoside 9h
分子名称: Cholera Toxin B Subunit, N-{3-[4-(3-AMINO-PROPYL)-PIPERAZIN-1-YL]-PROPYL}-3-(2-THIOPHEN-2-YL-ACETYLAMINO)-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE
著者Mitchell, D.D, Pickens, J.C, Korotkov, K, Fan, E, Hol, W.G.J.
登録日2003-07-11
公開日2004-03-09
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies
Bioorg.Med.Chem., 12, 2004
1PV2
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Native Form 2 E.coli Chaperone Hsp31
分子名称: Chaperone protein hchA
著者Quigley, P.M, Korotkov, K, Baneyx, F, Hol, W.G.J.
登録日2003-06-26
公開日2004-01-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献A new native EcHsp31 structure suggests a key role of structural flexibility for chaperone function.
Protein Sci., 13, 2004
1LPF
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THREE-DIMENSIONAL STRUCTURE OF LIPOAMIDE DEHYDROGENASE FROM PSEUDOMONAS FLUORESCENS AT 2.8 ANGSTROMS RESOLUTION. ANALYSIS OF REDOX AND THERMOSTABILITY PROPERTIES
分子名称: DIHYDROLIPOAMIDE DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE
著者Mattevi, A, Hol, W.
登録日1992-10-26
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties.
J.Mol.Biol., 230, 1993
1PZJ
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Cholera Toxin B-Pentamer Complexed With Nitrophenyl Galactoside 5
分子名称: Cholera Toxin B Subunit, N-{3-[4-(3-AMINO-PROPYL)-PIPERAZIN-1-YL]-PROPYL}-3-NITRO-5-(GALACTOPYRANOSYL)-ALPHA-BENZAMIDE, N-{3-[4-(3-AMINO-PROPYL)-PIPERAZIN-1-YL]-PROPYL}-3-NITRO-5-(GALACTOPYRANOSYL)-BETA-BENZAMIDE
著者Mitchell, D.D, Pickens, J.C, Korotkov, K, Fan, E, Hol, W.G.J.
登録日2003-07-11
公開日2004-03-09
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies
Bioorg.Med.Chem., 12, 2004
1PZI
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Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a
分子名称: Heat-labile Enterotoxin B subunit, N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE
著者Mitchell, D.D, Pickens, J.C, Korotkov, K, Fan, E, Hol, W.G.J.
登録日2003-07-11
公開日2004-03-09
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies
Bioorg.Med.Chem., 12, 2004
1N1G
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Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase with inhibitor BCP
分子名称: 2-BROMO-6-CHLORO-PURINE, PALMITIC ACID, glycerol-3-phosphate dehydrogenase
著者Choe, J, Hol, W.G.
登録日2002-10-17
公開日2003-10-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase.
Chem.Biol., 9, 2002
1M67
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Crystal Structure of Leishmania mexicana GPDH Complexed with Inhibitor 2-bromo-6-hydroxy-purine
分子名称: 2-BROMO-6-HYDROXY-PURINE, Glycerol-3-phosphate dehydrogenase, PALMITIC ACID
著者Choe, J, Suresh, S, Wisedchaisri, G, Kennedy, K.J, Gelb, M.H, Hol, W.G.J.
登録日2002-07-12
公開日2002-12-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase
Chem.Biol., 9, 2002
4PHC
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Crystal Structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound
分子名称: GLYCEROL, HISTIDINE, Histidine--tRNA ligase, ...
著者Koh, C.Y, Wetzel, A.B, de van der Schueren, W.J, Hol, W.G.J.
登録日2014-05-06
公開日2014-08-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.844 Å)
主引用文献Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.
Biochimie, 106, 2014
4MWB
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1509)
分子名称: 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
登録日2013-09-24
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.313 Å)
主引用文献Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014
4MW9
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1478)
分子名称: 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
登録日2013-09-24
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014
4MVW
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433)
分子名称: 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
登録日2013-09-24
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014
4MWE
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy)benzyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1475)
分子名称: 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy)benzyl]amino}propyl)-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
登録日2013-09-24
公開日2014-04-30
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014

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