6EI1
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![BU of 6ei1 by Molmil](/molmil-images/mine/6ei1) | Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA | Descriptor: | GLYCEROL, MALONATE ION, Polyubiquitin-B, ... | Authors: | Pichlo, C, Baumann, U, Hofmann, K, Hermanns, T. | Deposit date: | 2017-09-16 | Release date: | 2018-03-07 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.732 Å) | Cite: | A family of unconventional deubiquitinases with modular chain specificity determinants. Nat Commun, 9, 2018
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8CMR
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![BU of 8cmr by Molmil](/molmil-images/mine/8cmr) | Linear specific OTU-type DUB SnOTU from the pathogen S. negenvensis in complex with linear di-ubiquitin | Descriptor: | OTU domain-containing protein, Polyubiquitin-B | Authors: | Uthoff, M, Hermanns, T, Boll, V, Hofmann, K, Baumann, U. | Deposit date: | 2023-02-21 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Functional and structural diversity in deubiquitinases of the Chlamydia-like bacterium Simkania negevensis. Nat Commun, 14, 2023
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7OJE
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![BU of 7oje by Molmil](/molmil-images/mine/7oje) | Crystal structure of the covalent complex between Tribolium castaneum deubiquitinase ZUP and Ubiquitin-PA | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Lys-63-specific deubiquitinase ZUFSP, ... | Authors: | Pichlo, C, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2021-05-14 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nat Commun, 13, 2022
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8ADD
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![BU of 8add by Molmil](/molmil-images/mine/8add) | Viral tegument-like DUBs | Descriptor: | ATP-dependent DNA helicase | Authors: | Erven, I, Abraham, E.T, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2022-07-08 | Release date: | 2023-02-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins. Nat Commun, 13, 2022
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8Q00
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![BU of 8q00 by Molmil](/molmil-images/mine/8q00) | TssM-Ub-PA complex - A USP-like DUB from B. pseudomallei (193-430) reacted with Ub-PA | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, Polyubiquitin-B, ... | Authors: | Uthoff, M, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2023-07-27 | Release date: | 2023-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | The structural basis for deubiquitination by the fingerless USP-type effector TssM. Life Sci Alliance, 7, 2024
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7OIY
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![BU of 7oiy by Molmil](/molmil-images/mine/7oiy) | Crystal structure of the ZUFSP family member Mug105 | Descriptor: | SODIUM ION, Ubiquitin carboxyl-terminal hydrolase mug105 | Authors: | Pichlo, C, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2021-05-12 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nat Commun, 13, 2022
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4J4Q
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![BU of 4j4q by Molmil](/molmil-images/mine/4j4q) | Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside | Descriptor: | ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ... | Authors: | Park, J.H, Morizumi, T, Li, Y, Hong, J.E, Pai, E.F, Hofmann, K.P, Choe, H.W, Ernst, O.P. | Deposit date: | 2013-02-07 | Release date: | 2013-10-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Opsin, a structural model for olfactory receptors? Angew.Chem.Int.Ed.Engl., 52, 2013
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8PZ3
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![BU of 8pz3 by Molmil](/molmil-images/mine/8pz3) | |
8ADB
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![BU of 8adb by Molmil](/molmil-images/mine/8adb) | Viral tegument-like DUBs | Descriptor: | CITRIC ACID, Polyubiquitin-C, Wc-VDT1, ... | Authors: | Erven, I, Abraham, E.T, Hermanns, T, Baumann, U, Hofmann, K. | Deposit date: | 2022-07-08 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins. Nat Commun, 13, 2022
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8ADC
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![BU of 8adc by Molmil](/molmil-images/mine/8adc) | Viral tegument-like DUBs | Descriptor: | Viral deubiquitinating enzyme | Authors: | Erven, I, Abraham, E.T, Hermanns, T, Baumann, U, Hofmann, K. | Deposit date: | 2022-07-08 | Release date: | 2023-02-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins. Nat Commun, 13, 2022
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4BKG
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![BU of 4bkg by Molmil](/molmil-images/mine/4bkg) | crystal structure of human diSUMO-2 | Descriptor: | SMALL UBIQUITIN-RELATED MODIFIER 2 | Authors: | Keusekotten, K, Bade, V.N, Meyer-Teschendorf, K, Sriramachandran, A, Fischer-Schrader, K, Krause, A, Horst, C, Hofmann, K, Dohmen, R.J, Praefcke, G.J.K. | Deposit date: | 2013-04-25 | Release date: | 2013-11-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Multivalent Interactions of the Sumo-Interaction Motifs in the Ring-Finger Protein 4 (Rnf4) Determine the Specificity for Chains of the Small Ubiquitin-Related Modifier (Sumo). Biochem.J., 457, 2014
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3ZNV
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![BU of 3znv by Molmil](/molmil-images/mine/3znv) | Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms. | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | Deposit date: | 2013-02-18 | Release date: | 2013-06-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin. Cell(Cambridge,Mass.), 153, 2013
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3ZNZ
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![BU of 3znz by Molmil](/molmil-images/mine/3znz) | Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin | Descriptor: | POLYUBIQUITIN-C, PROTEIN FAM105B, SULFATE ION | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | Deposit date: | 2013-02-18 | Release date: | 2013-06-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin. Cell(Cambridge,Mass.), 153, 2013
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3ZNX
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![BU of 3znx by Molmil](/molmil-images/mine/3znx) | Crystal structure of the OTU domain of OTULIN D336A mutant | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | Deposit date: | 2013-02-18 | Release date: | 2013-06-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin. Cell(Cambridge,Mass.), 153, 2013
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4AE4
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![BU of 4ae4 by Molmil](/molmil-images/mine/4ae4) | The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, POTASSIUM ION, ... | Authors: | Agromayor, M, Soler, N, Caballe, A, Kueck, T, Freund, S.M, Allen, M.D, Bycroft, M, Perisic, O, Ye, Y, McDonald, B, Scheel, H, Hofmann, K, Neil, S.J.D, Martin-Serrano, J, Williams, R.L. | Deposit date: | 2012-01-06 | Release date: | 2012-03-21 | Last modified: | 2018-02-28 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure, 20, 2012
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3DQB
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![BU of 3dqb by Molmil](/molmil-images/mine/3dqb) | Crystal structure of the active G-protein-coupled receptor opsin in complex with a C-terminal peptide derived from the Galpha subunit of transducin | Descriptor: | 11meric peptide form Guanine nucleotide-binding protein G(t) subunit alpha-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ... | Authors: | Scheerer, P, Park, J.H, Hildebrand, P.W, Kim, Y.J, Krauss, N, Choe, H.-W, Hofmann, K.P, Ernst, O.P. | Deposit date: | 2008-07-09 | Release date: | 2008-09-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of opsin in its G-protein-interacting conformation Nature, 455, 2008
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7A9W
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![BU of 7a9w by Molmil](/molmil-images/mine/7a9w) | Structure of yeast Rmd9p in complex with 20nt target RNA | Descriptor: | CHLORIDE ION, Protein RMD9, mitochondrial, ... | Authors: | Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M. | Deposit date: | 2020-09-02 | Release date: | 2021-04-07 | Last modified: | 2021-05-05 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs. Proc.Natl.Acad.Sci.USA, 118, 2021
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7A9X
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![BU of 7a9x by Molmil](/molmil-images/mine/7a9x) | Structure of yeast Rmd9p in complex with 16nt target RNA | Descriptor: | CHLORIDE ION, Protein RMD9, mitochondrial, ... | Authors: | Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M. | Deposit date: | 2020-09-02 | Release date: | 2021-04-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs. Proc.Natl.Acad.Sci.USA, 118, 2021
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3CAP
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![BU of 3cap by Molmil](/molmil-images/mine/3cap) | Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State | Descriptor: | 2-O-octyl-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ... | Authors: | Park, J.H, Scheerer, P, Hofmann, K.P, Choe, H.-W, Ernst, O.P. | Deposit date: | 2008-02-20 | Release date: | 2008-06-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the ligand-free G-protein-coupled receptor opsin Nature, 454, 2008
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3PQR
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![BU of 3pqr by Molmil](/molmil-images/mine/3pqr) | Crystal structure of Metarhodopsin II in complex with a C-terminal peptide derived from the Galpha subunit of transducin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, ... | Authors: | Choe, H.-W, Kim, Y.J, Park, J.H, Morizumi, T, Pai, E.F, Krauss, N, Hofmann, K.P, Scheerer, P, Ernst, O.P. | Deposit date: | 2010-11-26 | Release date: | 2011-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal structure of metarhodopsin II. Nature, 471, 2011
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2WX0
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![BU of 2wx0 by Molmil](/molmil-images/mine/2wx0) | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21 | Descriptor: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | Authors: | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | Deposit date: | 2009-10-30 | Release date: | 2009-11-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain Nat.Struct.Mol.Biol., 16, 2009
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2WX1
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![BU of 2wx1 by Molmil](/molmil-images/mine/2wx1) | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked tri-ubiquitin, P212121 | Descriptor: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | Authors: | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | Deposit date: | 2009-10-30 | Release date: | 2009-11-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain Nat.Struct.Mol.Biol., 16, 2009
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2WWZ
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![BU of 2wwz by Molmil](/molmil-images/mine/2wwz) | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P212121 | Descriptor: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | Authors: | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | Deposit date: | 2009-10-30 | Release date: | 2009-11-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain Nat.Struct.Mol.Biol., 16, 2009
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3PXO
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![BU of 3pxo by Molmil](/molmil-images/mine/3pxo) | Crystal structure of Metarhodopsin II | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, RETINAL, ... | Authors: | Choe, H.-W, Kim, Y.J, Park, J.H, Morizumi, T, Pai, E.F, Krauss, N, Hofmann, K.P, Scheerer, P, Ernst, O.P. | Deposit date: | 2010-12-10 | Release date: | 2011-03-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of metarhodopsin II. Nature, 471, 2011
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1B89
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![BU of 1b89 by Molmil](/molmil-images/mine/1b89) | CLATHRIN HEAVY CHAIN PROXIMAL LEG SEGMENT (BOVINE) | Descriptor: | PROTEIN (CLATHRIN HEAVY CHAIN) | Authors: | Ybe, J.A, Brodsky, F.M, Hofmann, K, Lin, K, Liu, S.-H, Chen, L, Earnest, T.N, Fletterick, R.J, Hwang, P.K. | Deposit date: | 1999-05-27 | Release date: | 1999-06-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature, 399, 1999
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