1M55
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![BU of 1m55 by Molmil](/molmil-images/mine/1m55) | Catalytic domain of the Adeno Associated Virus type 5 Rep protein | Descriptor: | CHLORIDE ION, Rep protein, ZINC ION | Authors: | Hickman, A.B, Ronning, D.R, Kotin, R.M, Dyda, F. | Deposit date: | 2002-07-08 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol.Cell, 10, 2002
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2BW3
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![BU of 2bw3 by Molmil](/molmil-images/mine/2bw3) | Three-dimensional structure of the Hermes DNA transposase | Descriptor: | TRANSPOSASE | Authors: | Hickman, A.B, Perez, Z.N, Zhou, L, Musingarimi, P, Ghirlando, R, Hinshaw, J.E, Craig, N.L, Dyda, F. | Deposit date: | 2005-07-11 | Release date: | 2005-07-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular Architecture of a Eukaryotic DNA Transposase Nat.Struct.Mol.Biol., 12, 2005
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1CJW
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![BU of 1cjw by Molmil](/molmil-images/mine/1cjw) | SEROTONIN N-ACETYLTRANSFERASE COMPLEXED WITH A BISUBSTRATE ANALOG | Descriptor: | COA-S-ACETYL TRYPTAMINE, PROTEIN (SEROTONIN N-ACETYLTRANSFERASE) | Authors: | Hickman, A.B, Namboodiri, M.A.A, Klein, D.C, Dyda, F. | Deposit date: | 1999-04-19 | Release date: | 1999-05-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog. Cell(Cambridge,Mass.), 97, 1999
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1F1Z
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![BU of 1f1z by Molmil](/molmil-images/mine/1f1z) | TNSA, a catalytic component of the TN7 transposition system | Descriptor: | CHLORIDE ION, MAGNESIUM ION, TNSA ENDONUCLEASE | Authors: | Hickman, A.B, Li, Y, Mathew, S.V, May, E.W, Craig, N.L, Dyda, F. | Deposit date: | 2000-05-21 | Release date: | 2000-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Unexpected structural diversity in DNA recombination: the restriction endonuclease connection. Mol.Cell, 5, 2000
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1RZ9
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![BU of 1rz9 by Molmil](/molmil-images/mine/1rz9) | Crystal Structure of AAV Rep complexed with the Rep-binding sequence | Descriptor: | 26-MER, Rep protein | Authors: | Hickman, A.B, Ronning, D.R, Perez, Z.N, Kotin, R.M, Dyda, F. | Deposit date: | 2003-12-24 | Release date: | 2004-02-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol.Cell, 13, 2004
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2XQC
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![BU of 2xqc by Molmil](/molmil-images/mine/2xqc) | DEINOCOCCUS RADIODURANS ISDRA2 TRANSPOSASE COMPLEXED WITH LEFT END RECOGNITION AND CLEAVAGE SITE AND ZN | Descriptor: | 5'-D(TP*TP*GP*AP*TP*GP)-3', DRA2 TRANSPOSASE LEFT END RECOGNITION SEQUENCE, TRANSPOSASE, ... | Authors: | Hickman, A.B, James, J.A, Barabas, O, Pasternak, C, Ton-Hoang, B, Chandler, M, Sommer, S, Dyda, F. | Deposit date: | 2010-09-01 | Release date: | 2010-10-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | DNA Recognition and the Precleavage State During Single-Stranded DNA Transposition in D. Radiodurans. Embo J., 29, 2010
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2XO6
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![BU of 2xo6 by Molmil](/molmil-images/mine/2xo6) | DEINOCOCCUS RADIODURANS ISDRA2 TRANSPOSASE Y132F MUTANT COMPLEXED WITH LEFT END RECOGNITION AND CLEAVAGE SITE | Descriptor: | 5'-D(*TP*TP*GP*AP*TP*G)-3', ACETATE ION, CADMIUM ION, ... | Authors: | Hickman, A.B, James, J.A, Barabas, O, Pasternak, C, Ton-Hoang, B, Chandler, M, Sommer, S, Dyda, F. | Deposit date: | 2010-08-09 | Release date: | 2010-10-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | DNA Recognition and the Precleavage State During Single-Stranded DNA Transposition in D. Radiodurans. Embo J., 29, 2010
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2XMA
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![BU of 2xma by Molmil](/molmil-images/mine/2xma) | DEINOCOCCUS RADIODURANS ISDRA2 TRANSPOSASE RIGHT END DNA COMPLEX | Descriptor: | DRA2 TRANSPOSASE RIGHT END RECOGNITION SITE, MAGNESIUM ION, TRANSPOSASE | Authors: | Hickman, A.B, James, J.A, Barabas, O, Pasternak, C, Ton-Hoang, B, Chandler, M, Sommer, S, Dyda, F. | Deposit date: | 2010-07-26 | Release date: | 2010-10-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | DNA Recognition and the Precleavage State During Single-Stranded DNA Transposition in D. Radiodurans. Embo J., 29, 2010
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1AIH
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![BU of 1aih by Molmil](/molmil-images/mine/1aih) | CATALYTIC DOMAIN OF BACTERIOPHAGE HP1 INTEGRASE | Descriptor: | HP1 INTEGRASE, MAGNESIUM ION, SULFATE ION | Authors: | Hickman, A.B, Waninger, S, Scocca, J.J, Dyda, F. | Deposit date: | 1997-04-17 | Release date: | 1997-08-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular organization in site-specific recombination: the catalytic domain of bacteriophage HP1 integrase at 2.7 A resolution. Cell(Cambridge,Mass.), 89, 1997
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1B6B
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![BU of 1b6b by Molmil](/molmil-images/mine/1b6b) | |
4D1Q
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![BU of 4d1q by Molmil](/molmil-images/mine/4d1q) | Hermes transposase bound to its terminal inverted repeat | Descriptor: | SODIUM ION, TERMINAL INVERTED REPEAT, TRANSPOSASE | Authors: | Hickman, A.B, Ewis, H, Li, X, Knapp, J, Laver, T, Doss, A.L, Tolun, G, Steven, A, Grishaev, A, Bax, A, Atkinson, P, Craig, N.L, Dyda, F. | Deposit date: | 2014-05-04 | Release date: | 2014-07-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural Basis of Hat Transposon End Recognition by Hermes, an Octameric DNA Transposase from Musca Domestica. Cell(Cambridge,Mass.), 158, 2014
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2XM3
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![BU of 2xm3 by Molmil](/molmil-images/mine/2xm3) | Deinococcus radiodurans ISDra2 Transposase Left end DNA complex | Descriptor: | 5'-D(*TP*TP*AP*GP*T)-3', ACETATE ION, DRA2 TRANSPOSASE BINDING ELEMENT, ... | Authors: | Hickman, A.B, James, J.A, Barabas, O, Pasternak, C, Ton-Hoang, B, Chandler, M, Sommer, S, Dyda, F. | Deposit date: | 2010-07-22 | Release date: | 2010-10-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | DNA Recognition and the Precleavage State During Single-Stranded DNA Transposition in D. Radiodurans. Embo J., 29, 2010
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6DWZ
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![BU of 6dwz by Molmil](/molmil-images/mine/6dwz) | Hermes transposase deletion dimer complex with (C/G) DNA | Descriptor: | DNA (26-MER), DNA (5'-D(*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), DNA (5'-D(*GP*CP*GP*TP*GP*AP*C)-3'), ... | Authors: | Dyda, F, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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6X68
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![BU of 6x68 by Molmil](/molmil-images/mine/6x68) | Cryo-EM structure of piggyBac transposase synaptic complex with hairpin DNA (SNHP) | Descriptor: | CALCIUM ION, Transposase, ZINC ION, ... | Authors: | Chen, Q, Hickman, A.B, Dyda, F. | Deposit date: | 2020-05-27 | Release date: | 2020-07-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structural basis of seamless excision and specific targeting by piggyBac transposase Nat Commun, 11, 2020
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5LME
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![BU of 5lme by Molmil](/molmil-images/mine/5lme) | Specific-DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase | Descriptor: | ZINC ION, piggyBac transposase | Authors: | Morellet, N, Taylor, J.A, Wieninger, S, Moriau, S, Li, X, Lescop, E, Mathy, N, Bischerour, J, Betermier, M, Bardiaux, B, Nilges, M, Craig, N.L, Hickman, A.B, Dyda, F, Guittet, E. | Deposit date: | 2016-07-30 | Release date: | 2017-12-20 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase. Nucleic Acids Res., 46, 2018
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1T0F
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![BU of 1t0f by Molmil](/molmil-images/mine/1t0f) | Crystal Structure of the TnsA/TnsC(504-555) complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, MALONIC ACID, ... | Authors: | Ronning, D.R, Li, Y, Perez, Z.N, Ross, P.D, Hickman, A.B, Craig, N.L, Dyda, F. | Deposit date: | 2004-04-08 | Release date: | 2004-11-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA. Embo J., 23, 2004
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1ITG
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![BU of 1itg by Molmil](/molmil-images/mine/1itg) | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES | Descriptor: | CACODYLATE ION, HIV-1 INTEGRASE | Authors: | Dyda, F, Hickman, A.B, Jenkins, T.M, Engelman, A, Craigie, R, Davies, D.R. | Deposit date: | 1994-11-21 | Release date: | 1995-05-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science, 266, 1994
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6DX0
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![BU of 6dx0 by Molmil](/molmil-images/mine/6dx0) | Hermes transposase deletion dimer complex with (A/T) DNA | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), DNA (5'-D(*GP*CP*GP*TP*GP*AP*A)-3'), ... | Authors: | Dyda, F, Voth, A.R, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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6DWY
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![BU of 6dwy by Molmil](/molmil-images/mine/6dwy) | Hermes transposase deletion dimer complex with (C/G) DNA and Ca2+ | Descriptor: | CALCIUM ION, DNA (26-MER), DNA (5'-D(*AP*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), ... | Authors: | Dyda, F, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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6DWW
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![BU of 6dww by Molmil](/molmil-images/mine/6dww) | Hermes transposase deletion dimer complex with (A/T) DNA and Mn2+ | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), DNA (5'-D(*GP*CP*GP*TP*GP*AP*A)-3'), ... | Authors: | Dyda, F, Voth, A.R, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.851 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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6X67
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![BU of 6x67 by Molmil](/molmil-images/mine/6x67) | Cryo-EM structure of piggyBac transposase strand transfer complex (STC) | Descriptor: | CALCIUM ION, DNA (37-MER), DNA (47-MER), ... | Authors: | Chen, Q, Hickman, A.B, Dyda, F. | Deposit date: | 2020-05-27 | Release date: | 2020-07-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis of seamless excision and specific targeting by piggyBac transposase Nat Commun, 11, 2020
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1UUT
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![BU of 1uut by Molmil](/molmil-images/mine/1uut) | The Nuclease Domain of Adeno-Associated Virus Rep Complexed with the RBE' Stemloop of the Viral Inverted Terminal Repeat | Descriptor: | 5'-D(*CP*AP*GP*CP*TP*CP*TP*TP*TP*GP *AP*GP*CP*TP*G)-3', CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Dyda, F, Hickman, A.B, Ronning, D.R, Perez, Z.N, Kotin, R.M. | Deposit date: | 2004-01-10 | Release date: | 2004-02-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Nuclease Domain of Adeno-Associated Virus Rep Coordinates Replication Initiation Using Two Distinct DNA Recognition Interfaces Mol.Cell, 13, 2004
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7TH0
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![BU of 7th0 by Molmil](/molmil-images/mine/7th0) | Escherichia coli RpnA-S | Descriptor: | Recombination-promoting nuclease RpnA | Authors: | Zhong, A, Hickman, A.B, Storz, G, Dyda, F. | Deposit date: | 2022-01-10 | Release date: | 2023-03-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Toxic antiphage defense proteins inhibited by intragenic antitoxin proteins. Proc.Natl.Acad.Sci.USA, 120, 2023
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1BIS
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![BU of 1bis by Molmil](/molmil-images/mine/1bis) | HIV-1 INTEGRASE CORE DOMAIN | Descriptor: | HIV-1 INTEGRASE | Authors: | Goldgur, Y, Dyda, F, Hickman, A.B, Jenkins, T.M, Craigie, R, Davies, D.R. | Deposit date: | 1998-06-19 | Release date: | 1998-08-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc.Natl.Acad.Sci.USA, 95, 1998
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1BIZ
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![BU of 1biz by Molmil](/molmil-images/mine/1biz) | HIV-1 INTEGRASE CORE DOMAIN | Descriptor: | CACODYLATE ION, HIV-1 INTEGRASE | Authors: | Goldgur, Y, Dyda, F, Hickman, A.B, Jenkins, T.M, Craigie, R, Davies, D.R. | Deposit date: | 1998-06-21 | Release date: | 1998-08-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc.Natl.Acad.Sci.USA, 95, 1998
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