7B8S
| Fusidic acid bound structure of bacterial efflux pump. | 分子名称: | DARPin, FUSIDIC ACID, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7B8T
| Levofloxacin bound structure of bacterial efflux pump. | 分子名称: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7B8R
| Doxycycline bound structure of bacterial efflux pump. | 分子名称: | (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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6SV3
| Structure of coproheme-LmCpfC | 分子名称: | 1,3,5,8-TETRAMETHYL-PORPHINE-2,4,6,7-TETRAPROPIONIC ACID FERROUS COMPLEX, Ferrochelatase, GLYCEROL | 著者 | Hofbauer, S, Helm, J, Djinovic-Carugo, K, Furtmueller, P.G. | 登録日 | 2019-09-17 | 公開日 | 2019-12-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.64000869 Å) | 主引用文献 | Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase. Febs J., 287, 2020
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6RWV
| Structure of apo-LmCpfC | 分子名称: | Ferrochelatase, GLYCEROL, PHOSPHATE ION, ... | 著者 | Hofbauer, S, Helm, J, Djinovic-Carugo, K, Furtmueller, P.G. | 登録日 | 2019-06-06 | 公開日 | 2019-12-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6386379 Å) | 主引用文献 | Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase. Febs J., 287, 2020
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4AIW
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1SMB
| Crystal Structure of Golgi-Associated PR-1 protein | 分子名称: | 17kD fetal brain protein | 著者 | Serrano, R.L, Kuhn, A, Hendricks, A, Helms, J.B, Sinning, I, Groves, M.R. | 登録日 | 2004-03-08 | 公開日 | 2004-09-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism J.Mol.Biol., 339, 2004
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1Z9C
| Crystal structure of OhrR bound to the ohrA promoter: Structure of MarR family protein with operator DNA | 分子名称: | DNA (29-MER), Organic hydroperoxide resistance transcriptional regulator | 著者 | Hong, M, Fuangthong, M, Helmann, J.D, Brennan, R.G. | 登録日 | 2005-04-01 | 公開日 | 2005-10-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structure of an OhrR-ohrA Operator Complex Reveals the DNA Binding Mechanism of the MarR Family. Mol.Cell, 20, 2005
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2K2G
| Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor | 分子名称: | Macrophage metalloelastase, N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine, ZINC ION | 著者 | Markus, M.A, Dwyer, B, Wolfrom, S, Li, J, Li, W, Malakian, K, Wilhelm, J, Tsao, D.H.H. | 登録日 | 2008-04-01 | 公開日 | 2008-05-20 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor. J.Biomol.Nmr, 41, 2008
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4MRO
| Human GKRP bound to AMG-5980 and S6P | 分子名称: | 2-(4-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | St Jean, D.J, Ashton, K.S, Bartberger, M.D, Chen, J, Chmait, S, Cupples, R, Galbreath, E, Helmering, J, Jordan, S.R, Liu, L, Kunz, K, Michelsen, K, Nishimura, N, Pennington, L.D, Poon, S.F, Sivits, G, Stec, M.M, Tamayo, N, Van, G, Yang, K, Norman, M.H, Fotsch, C, LLoyd, D.J, Hale, C. | 登録日 | 2013-09-17 | 公開日 | 2014-05-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. J.Med.Chem., 57, 2014
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4MSU
| Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate | 分子名称: | 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Ashton, K.S, Andrews, K.L, Bryan, M.C, Chen, J, Chen, K, Chen, M, Chmait, S, Croghan, M, Cupples, R, Fotsch, C, Helmering, J, Jordan, S.R, Kurzeja, R.J, Michelsen, K, Pennington, L.D, Poon, S.F, Sivits, G, Van, G, Vonderfecht, S.L, Wahl, R.C, Zhang, J, Lloyd, D.J, Hale, C, St Jean, D.J. | 登録日 | 2013-09-18 | 公開日 | 2014-03-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept. J.Med.Chem., 57, 2014
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4MQU
| Human GKRP complexed to AMG-3969 and S6P | 分子名称: | 2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | St Jean, D.J, Ashton, K.S, Bartberger, M.D, Chen, J, Chmait, S, Cupples, R, Galbreath, E, Helmering, J, Jordan, S.R, Liu, L. | 登録日 | 2013-09-16 | 公開日 | 2014-05-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. J.Med.Chem., 57, 2014
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1IJZ
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1IK0
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3K1K
| Green fluorescent protein bound to enhancer nanobody | 分子名称: | Enhancer, Green Fluorescent Protein | 著者 | Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U. | 登録日 | 2009-09-28 | 公開日 | 2009-12-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Modulation of protein properties in living cells using nanobodies Nat.Struct.Mol.Biol., 17, 2010
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2EV0
| Bacillus subtilis manganese transport regulator (MNTR) bound to cadmium | 分子名称: | CADMIUM ION, Transcriptional regulator mntR | 著者 | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | 登録日 | 2005-10-30 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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2EV5
| Bacillus subtilis manganese transport regulator (MNTR) bound to calcium | 分子名称: | CALCIUM ION, Transcriptional regulator mntR | 著者 | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | 登録日 | 2005-10-31 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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2F5C
| Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form | 分子名称: | MANGANESE (II) ION, SULFATE ION, Transcriptional regulator mntR | 著者 | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | 登録日 | 2005-11-25 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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2F5F
| Bacillus subtilis manganese transport regulator (MNTR) bound to manganese, AC conformation, pH 8.5 | 分子名称: | MANGANESE (II) ION, Transcriptional regulator mntR | 著者 | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | 登録日 | 2005-11-25 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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2F5D
| Bacillus subtilis manganese transport regulator (MNTR) bound to manganese, AC conformation, pH 6.5 | 分子名称: | MANGANESE (II) ION, Transcriptional regulator mntR | 著者 | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | 登録日 | 2005-11-25 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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2EV6
| Bacillus subtilis manganese transport regulator (MNTR) bound to zinc | 分子名称: | CITRATE ANION, GLYCEROL, Transcriptional regulator mntR, ... | 著者 | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | 登録日 | 2005-10-31 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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2F5E
| Bacillus subtilis manganese transport regulator (MNTR) bound to manganese, AB conformation, pH 6.5 | 分子名称: | MANGANESE (II) ION, Transcriptional regulator mntR | 著者 | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | 登録日 | 2005-11-25 | 公開日 | 2006-03-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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1Z91
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3G9A
| Green fluorescent protein bound to minimizer nanobody | 分子名称: | Green fluorescent protein, Minimizer | 著者 | Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U. | 登録日 | 2009-02-13 | 公開日 | 2009-12-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.614 Å) | 主引用文献 | Modulation of protein properties in living cells using nanobodies Nat.Struct.Mol.Biol., 17, 2010
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2XV6
| Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH. | 分子名称: | CAMELID VHH 9, CAPSID PROTEIN P24 | 著者 | Igonet, S, Vaney, M.C, Bartonova, V, Helma, J, Rothbauer, U, Leonhardt, H, Stura, E, Krausslich, H.-G, Rey, F.A. | 登録日 | 2010-10-22 | 公開日 | 2011-10-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors To be Published
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