3FJ6
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![BU of 3fj6 by Molmil](/molmil-images/mine/3fj6) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2 | Descriptor: | (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETATE ION, Dihydroorotate dehydrogenase, ... | Authors: | Heikkila, T. | Deposit date: | 2008-12-14 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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3F1Q
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![BU of 3f1q by Molmil](/molmil-images/mine/3f1q) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1 | Descriptor: | (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... | Authors: | Heikkila, T, Davies, M, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2008-10-28 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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3FJL
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![BU of 3fjl by Molmil](/molmil-images/mine/3fjl) | |
3G0U
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![BU of 3g0u by Molmil](/molmil-images/mine/3g0u) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4 | Descriptor: | (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Davis, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2009-01-28 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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3G0X
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![BU of 3g0x by Molmil](/molmil-images/mine/3g0x) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5 | Descriptor: | (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Davies, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2009-01-29 | Release date: | 2009-06-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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