8V3X
 
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8V40
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7DV4
 | | Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 | | 分子名称: | 1,2-ETHANEDIOL, 4003-1(VH), Cytotoxic T-lymphocyte protein 4 | | 著者 | Li, H, Gan, X, He, Y. | | 登録日 | 2021-01-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8W6I
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8W6J
 | | Cryo-EM structure of Escherichia coli Str K12 FtsE(E163Q)X/EnvC complex with ATP in peptidisc | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | | 著者 | Li, J, Xu, X, He, Y, Luo, M. | | 登録日 | 2023-08-29 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structure of Escherichia coli Str K12 FtsE(E163Q)X/EnvC complex with ATP in peptidisc
To Be Published
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7DPX
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7DVA
 | | Structure of wild type Bt4394, a GH20 family sulfoglycosidase, in complex with 6S-GlcNAc | | 分子名称: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, GLYCEROL | | 著者 | Zhang, Z, He, Y, Jin, Y. | | 登録日 | 2021-01-13 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 13, 2023
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7DUP
 | | Apo structure of wild type Bt4394, a GH20 family sulfoglycosidase | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | | 著者 | Zhang, Z, He, Y, Jin, Y. | | 登録日 | 2021-01-10 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 13, 2023
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7DVB
 | | D335N variant of Bt4394 in complex with 6SO3-NAG-oxazoline intermediate | | 分子名称: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, [(3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-2-methyl-6,7-bis(oxidanyl)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d][1,3]oxazol-1-ium-5-yl]methyl sulfate | | 著者 | Zhang, Z, He, Y, Jin, Y. | | 登録日 | 2021-01-13 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 13, 2023
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8GA8
 | | Structure of the yeast (HDAC) Rpd3L complex | | 分子名称: | Histone deacetylase RPD3, Transcriptional regulatory protein DEP1, Transcriptional regulatory protein PHO23, ... | | 著者 | Patel, A.B, Radhakrishnan, I, He, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex.
Nat Commun, 14, 2023
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6JLI
 | | Crystal structure of CTLD7 domain of human PLA2R | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Secretory phospholipase A2 receptor | | 著者 | Yu, B, Hu, Z, Kong, D, Cheng, C, He, Y. | | 登録日 | 2019-03-06 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.778 Å) | | 主引用文献 | Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor.
J.Struct.Biol., 207, 2019
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7EK6
 | | Structure of viral peptides IPB19/N52 | | 分子名称: | Spike protein S2 | | 著者 | Yu, D, Qin, B, Cui, S, He, Y. | | 登録日 | 2021-04-04 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.243 Å) | | 主引用文献 | Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants.
Emerg Microbes Infect, 10, 2021
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5XBF
 | | Crystal Structure of Myo7b C-terminal MyTH4-FERM in complex with USH1C PDZ3 | | 分子名称: | ACETATE ION, D-MALATE, GLYCEROL, ... | | 著者 | Li, J, He, Y, Weck, W.L, Lu, Q, Tyska, M.J, Zhang, M. | | 登録日 | 2017-03-17 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7WHW
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with AMPPCP (E1-ATP state) | | 分子名称: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2021-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7WHV
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with beryllium fluoride (E2P state) | | 分子名称: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Alkylphosphocholine resistance protein LEM3, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2021-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7F7F
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in yeast lipids with beryllium fluoride (resting state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkylphosphocholine resistance protein LEM3, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2021-06-29 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7DRX
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with beryllium fluoride (E2P state) | | 分子名称: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Alkylphosphocholine resistance protein LEM3, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2020-12-30 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7DSH
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with AMPPCP (E1-ATP state) | | 分子名称: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2020-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7DSI
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in yeast lipids with AMPPCP ( resting state ) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkylphosphocholine resistance protein LEM3, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2020-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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3FXV
 | | Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist | | 分子名称: | 12-meric peptide from Nuclear receptor coactivator 1, 6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid, NR1H4 protein | | 著者 | Feng, S, Yang, M, He, Y, Chen, L, Zhang, Z, Wang, Z, Hong, D, Richter, H, Benson, G.M, Bleicher, K, Grether, U, Martin, R, Plancher, J.-M, Kuhn, B, Rudolph, M.G. | | 登録日 | 2009-01-21 | | 公開日 | 2009-04-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist
Bioorg.Med.Chem.Lett., 19, 2009
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