8H9S
 
 | | Human ATP synthase state 1 (combined) | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9N
 | | Human ATP synthase state 3a subregion 2 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase subunit d, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9M
 | | Human ATP synthase state 3a subregion 3 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase F(0) complex subunit C1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9E
 | | Human ATP synthase F1 domain, state 1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase subunit O, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9G
 | | Human ATP synthase state 1 subregion 2 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase subunit d, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9K
 | | Human ATP synthase state 2 subregion 2 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase subunit d, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9L
 | | Human ATP synthase F1 domain, state 3a | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase subunit O, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9J
 | | Human ATP synthase state2 subregion 3 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase F(0) complex subunit C1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9T
 | | Human ATP synthase state 2 (combined) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F(0) complex subunit B1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8V2F
 | | Crystal structure of IRAK4 kinase domain with compound 9 | | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | 登録日 | 2023-11-22 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
J.Med.Chem., 67, 2024
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8V1O
 | | Crystal structure of IRAK4 kinase domain with compound 4 | | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | 登録日 | 2023-11-21 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
J.Med.Chem., 67, 2024
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3PGL
 | | Crystal structure of human small C-terminal domain phosphatase 1 (Scp1) bound to rabeprazole | | 分子名称: | 2-[(R)-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl]-1H-benzimidazole, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, MAGNESIUM ION | | 著者 | Zhang, M, Cho, E.J, Burstein, G, Siegel, D, Zhang, Y. | | 登録日 | 2010-11-02 | | 公開日 | 2011-03-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor.
Acs Chem.Biol., 6, 2011
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8V2L
 | | Crystal structure of IRAK4 kinase domain with compound 8 | | 分子名称: | 1,2-ETHANEDIOL, Interleukin-1 receptor-associated kinase 4, N-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | 登録日 | 2023-11-22 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
J.Med.Chem., 67, 2024
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5Y8C
 | | Crystal Structure Analysis of the BRD4 | | 分子名称: | 1,2-ETHANEDIOL, 5-chloranyl-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzoxazol-5-yl)benzenesulfonamide, Bromodomain-containing protein 4, ... | | 著者 | Xu, Y, Zhang, Y, Song, M, Wang, C. | | 登録日 | 2017-08-21 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018
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8P7I
 | | The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes | | 分子名称: | (2~{S},6~{R})-2,6-dimethyl-1,3-dioxane-4,4-diol, FORMIC ACID, Parathion hydrolase, ... | | 著者 | Dym, O, Aggarwal, N, Ashani, Y, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Sussman, J.L. | | 登録日 | 2023-05-30 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.
Acta Crystallogr D Struct Biol, 79, 2023
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8P7H
 | | The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes | | 分子名称: | 1,2-ETHANEDIOL, 2-methylidene-1,3-dioxane-4,4-diol, FORMIC ACID, ... | | 著者 | Dym, O, Aggarwal, N, Ashani, Y, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Sussman, J.L. | | 登録日 | 2023-05-30 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.774 Å) | | 主引用文献 | The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.
Acta Crystallogr D Struct Biol, 79, 2023
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2I04
 | | X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 | | 分子名称: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, SULFATE ION, ... | | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | | 登録日 | 2006-08-09 | | 公開日 | 2007-02-20 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein.
J.Virol., 81, 2007
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8P7F
 | | The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes | | 分子名称: | Parathion hydrolase, ZINC ION | | 著者 | Dym, O, Aggarwal, N, Ashani, Y, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Sussman, J.L. | | 登録日 | 2023-05-30 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.
Acta Crystallogr D Struct Biol, 79, 2023
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2I0L
 | | X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6. | | 分子名称: | Disks large homolog 1, peptide E6 | | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | | 登録日 | 2006-08-10 | | 公開日 | 2007-02-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein.
J.Virol., 81, 2007
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8H9F
 | | Human ATP synthase state 1 subregion 3 | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, ATP synthase F(0) complex subunit B1, mitochondrial, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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6FS3
 | | Phosphotriesterase PTE_A53_1 | | 分子名称: | (2~{S})-2-methylpentanedioic acid, FORMIC ACID, Parathion hydrolase, ... | | 著者 | Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J. | | 登録日 | 2018-02-19 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal structures of Bacterail Phosphotriesterase variant with high catalytic activity towards organophosphate nerve agents developed by use of structure-based design and molecular evolution
To Be Published
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7B38
 | | Torpedo californica acetylcholinesterase complexed with Mg+2 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ... | | 著者 | Silman, I, Shnyrov, V.L, Ashani, Y, Roth, E, Nicolas, A, Sussman, J.L, Weiner, L. | | 登録日 | 2020-11-29 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Protein Sci., 30, 2021
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7B8E
 | | Torpedo californica acetylcholinesterase complexed with Ca+2 | | 分子名称: | 1,2-ETHANEDIOL, 2-[2-(2-ethoxyethoxy)ethoxy]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Silman, I, Shnyrov, V.L, Ashani, Y, Roth, E, Nicolas, A, Sussman, J.L. | | 登録日 | 2020-12-12 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Protein Sci., 30, 2021
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7B2W
 | | Torpedo californica acetylcholinesterase complexed with UO2 | | 分子名称: | Acetylcholinesterase, URANYL (VI) ION | | 著者 | Silman, I, Shnyrov, V.L, Ashani, Y, Roth, E, Nicolas, A, Sussman, J.L, Weiner, L. | | 登録日 | 2020-11-28 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Protein Sci., 30, 2021
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2X18
 | | The crystal structure of the PH domain of human AKT3 protein kinase | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE | | 著者 | Vollmar, M, Wang, J, Zhang, Y, Elkins, J.M, Burgess-Brown, N, Chaikuad, A, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S. | | 登録日 | 2009-12-22 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | The Crystal Structure of the Ph Domain of Human Akt3 Protein Kinase
To be Published
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