6CK3
| Co-crytsal Structure of MNK2 in Complex With an Inhibitor | 分子名称: | (3R)-3-methyl-5-[(pyrimidin-4-yl)amino]-2,3-dihydro-1H-isoindol-1-one, CHLORIDE ION, MAP kinase-interacting serine/threonine-protein kinase 2, ... | 著者 | Han, Q. | 登録日 | 2018-02-27 | 公開日 | 2018-05-09 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
|
|
6CJW
| Crystal Structure of Mnk2-D228G in Complex With Inhibitor | 分子名称: | 3-(pyridin-4-yl)imidazo[1,2-b]pyridazine, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | 著者 | Han, Q. | 登録日 | 2018-02-27 | 公開日 | 2018-05-09 | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | 主引用文献 | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
|
|
1DHT
| ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED DIHYDROTESTOSTERONE | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE | 著者 | Han, Q, Campbell, R.L, Gangloff, A, Lin, S.X. | 登録日 | 1998-03-25 | 公開日 | 1999-09-25 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain. J.Biol.Chem., 275, 2000
|
|
1YIY
| Aedes aegypti kynurenine aminotransferase | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, BROMIDE ION, kynurenine aminotransferase; glutamine transaminase K | 著者 | Han, Q, Gao, Y.G, Robinson, H, Ding, H, Wilson, S, Li, J. | 登録日 | 2005-01-13 | 公開日 | 2005-05-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of Aedes aegypti kynurenine aminotransferase. FEBS J., 272, 2005
|
|
1YIZ
| Aedes aegypti kynurenine aminotrasferase | 分子名称: | BROMIDE ION, kynurenine aminotransferase; glutamine transaminase | 著者 | Han, Q, Gao, Y.G, Robinson, H, Ding, H, Wilson, S, Li, J. | 登録日 | 2005-01-13 | 公開日 | 2005-05-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structures of Aedes aegypti kynurenine aminotransferase. FEBS J., 272, 2005
|
|
3D28
| Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor | 分子名称: | (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one, RNA-directed RNA polymerase | 著者 | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | 登録日 | 2008-05-07 | 公開日 | 2009-05-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
|
|
4E14
| Crystal structure of kynurenine formamidase conjugated with phenylmethylsulfonyl fluoride | 分子名称: | 1,2-ETHANEDIOL, SODIUM ION, kynurenine formamidase | 著者 | Han, Q, Robinson, H, Li, J. | 登録日 | 2012-03-05 | 公開日 | 2012-06-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem.J., 446, 2012
|
|
4E11
| Crystal structure of kynurenine formamidase from Drosophila melanogaster | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, SODIUM ION, ... | 著者 | Han, Q, Robinson, H, Li, J. | 登録日 | 2012-03-05 | 公開日 | 2012-06-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem.J., 446, 2012
|
|
4E15
| |
3PD6
| Crystal structure of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV | 分子名称: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, ... | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | 登録日 | 2010-10-22 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV. Biosci.Rep., 31, 2011
|
|
3PDB
| Crystal structure of mouse mitochondrial aspartate aminotransferase in complex with oxaloacetic acid | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, mitochondrial, ... | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | 登録日 | 2010-10-22 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV. Biosci.Rep., 31, 2011
|
|
4Z8U
| CRYSTAL STRUCTURE OF AvrRxo1-ORF1:-ORF2 WITH ATP | 分子名称: | ACETATE ION, AvrRxo1-ORF1, AvrRxo1-ORF2, ... | 著者 | Han, Q, Zhou, C, Wu, S, Liu, Y, Yang, Z, Miao, J, Triplett, L, Cheng, Q, Tokuhisa, J, Deblais, L, Robinson, H, Leach, J.E, Li, J, Zhao, B. | 登録日 | 2015-04-09 | 公開日 | 2015-09-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal Structure of Xanthomonas AvrRxo1-ORF1, a Type III Effector with a Polynucleotide Kinase Domain, and Its Interactor AvrRxo1-ORF2. Structure, 23, 2015
|
|
4Z8Q
| CRYSTAL STRUCTURE OF AvrRxo1-ORF1:AvrRxo1-ORF2 COMPLEX, SELENOMETHIONINE SUBSTITUTED. | 分子名称: | AvrRxo1-ORF1, AvrRxo1-ORF2, PHOSPHATE ION | 著者 | Han, Q, Zhou, C, Wu, S, Liu, Y, Yang, Z, Miao, J, Triplett, L, Cheng, Q, Tokuhisa, J, Deblais, L, Robinson, H, Leach, J.E, Li, J, Zhao, B. | 登録日 | 2015-04-09 | 公開日 | 2015-09-23 | 最終更新日 | 2022-03-16 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal Structure of Xanthomonas AvrRxo1-ORF1, a Type III Effector with a Polynucleotide Kinase Domain, and Its Interactor AvrRxo1-ORF2. Structure, 23, 2015
|
|
4Z8V
| CRYSTAL STRUCTURE OF AVRRXO1-ORF1:-ORF2 COMPLEX, NATIVE. | 分子名称: | AvrRxo1-ORF1, AvrRxo1-ORF2, PHOSPHATE ION | 著者 | Han, Q, Zhou, C, Wu, S, Liu, Y, Yang, Z, Miao, J, Triplett, L, Cheng, Q, Tokuhisa, J, Deblais, L, Robinson, H, Leach, J.E, Li, J, Zhao, B. | 登録日 | 2015-04-09 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Xanthomonas AvrRxo1-ORF1, a Type III Effector with a Polynucleotide Kinase Domain, and Its Interactor AvrRxo1-ORF2. Structure, 23, 2015
|
|
4Z8T
| CRYSTAL STRUCTURE OF AvrRxo1-ORF1:AvrRxo1-ORF2 WITH SULPHATE IONS | 分子名称: | ACETATE ION, AvrRxo1-ORF1, AvrRxo1-ORF2, ... | 著者 | Han, Q, Zhou, C, Wu, S, Liu, Y, Yang, Z, Miao, J, Triplett, L, Cheng, Q, Tokuhisa, J, Deblais, L, Robinson, H, Leach, J.E, Li, J, Zhao, B. | 登録日 | 2015-04-09 | 公開日 | 2015-09-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Crystal Structure of Xanthomonas AvrRxo1-ORF1, a Type III Effector with a Polynucleotide Kinase Domain, and Its Interactor AvrRxo1-ORF2. Structure, 23, 2015
|
|
2HUI
| Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with glyoxylic acid | 分子名称: | Alanine glyoxylate aminotransferase, GLYOXYLIC ACID | 著者 | Han, Q, Robinson, H, Gao, Y.G, Vogelaar, N, Wilson, S.R, Rizzi, M, Li, J. | 登録日 | 2006-07-26 | 公開日 | 2006-09-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal Structures of Aedes aegypti Alanine Glyoxylate Aminotransferase. J.Biol.Chem., 281, 2006
|
|
2HUU
| Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with alanine | 分子名称: | 1-BUTANOL, ALANINE, Alanine glyoxylate aminotransferase | 著者 | Han, Q, Robinson, H, Gao, Y.G, Vogelaar, N, Wilson, S.R, Rizzi, M, Li, J. | 登録日 | 2006-07-27 | 公開日 | 2006-09-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structures of Aedes aegypti Alanine Glyoxylate Aminotransferase. J.Biol.Chem., 281, 2006
|
|
2HUF
| Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase | 分子名称: | 1-BUTANOL, Alanine glyoxylate aminotransferase | 著者 | Han, Q, Robinson, H, Gao, Y.G, Vogelaar, N, Wilson, S.R, Rizzi, M, Li, J. | 登録日 | 2006-07-26 | 公開日 | 2006-09-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal Structures of Aedes aegypti Alanine Glyoxylate Aminotransferase. J.Biol.Chem., 281, 2006
|
|
7JMU
| Hen egg-white lysozyme with ionic liquid ethylammonium nitrate | 分子名称: | Lysozyme C, NITRATE ION | 著者 | Han, Q, Darmanin, C, Smith, K, Greaves, T, Drummond, C. | 登録日 | 2020-08-02 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Lysozyme conformational changes with ionic liquids: Spectroscopic, small angle x-ray scattering and crystallographic study. J Colloid Interface Sci, 585, 2021
|
|
3HLM
| Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase/Kynurenine Aminotransferase IV | 分子名称: | Aspartate aminotransferase, mitochondrial, GLYCEROL | 著者 | Han, Q, Robinson, H, Li, J. | 登録日 | 2009-05-27 | 公開日 | 2010-06-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Cell.Mol.Life Sci., 67, 2010
|
|
3K40
| Crystal structure of Drosophila 3,4-dihydroxyphenylalanine decarboxylase | 分子名称: | Aromatic-L-amino-acid decarboxylase, GLYCEROL | 著者 | Han, Q, Ding, H, Robinson, H, Christensen, B.M, Li, J. | 登録日 | 2009-10-05 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase Plos One, 5, 2010
|
|
3E51
| Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor | 分子名称: | N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-pyrrolidin-1-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | 登録日 | 2008-08-12 | 公開日 | 2009-08-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents. Bioorg.Med.Chem.Lett., 18, 2008
|
|
3CO9
| Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor | 分子名称: | N-{3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7 -yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | 登録日 | 2008-03-27 | 公開日 | 2009-02-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
|
|
3CWJ
| Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor | 分子名称: | N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-DIRECTED RNA POLYMERASE | 著者 | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | 登録日 | 2008-04-21 | 公開日 | 2009-04-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase Bioorg.Med.Chem.Lett., 18, 2008
|
|
4FD5
| |