6CJW
Crystal Structure of Mnk2-D228G in Complex With Inhibitor
Summary for 6CJW
Entry DOI | 10.2210/pdb6cjw/pdb |
Descriptor | MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION, 3-(pyridin-4-yl)imidazo[1,2-b]pyridazine, ... (4 entities in total) |
Functional Keywords | mnk2 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 2: Nucleus, PML body. Isoform 1: Cytoplasm: Q9HBH9 |
Total number of polymer chains | 1 |
Total formula weight | 35866.08 |
Authors | |
Primary citation | Reich, S.H.,Sprengeler, P.A.,Chiang, G.G.,Appleman, J.R.,Chen, J.,Clarine, J.,Eam, B.,Ernst, J.T.,Han, Q.,Goel, V.K.,Han, E.Z.R.,Huang, V.,Hung, I.N.J.,Jemison, A.,Jessen, K.A.,Molter, J.,Murphy, D.,Neal, M.,Parker, G.S.,Shaghafi, M.,Sperry, S.,Staunton, J.,Stumpf, C.R.,Thompson, P.A.,Tran, C.,Webber, S.E.,Wegerski, C.J.,Zheng, H.,Webster, K.R. Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61:3516-3540, 2018 Cited by PubMed: 29526098DOI: 10.1021/acs.jmedchem.7b01795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.38 Å) |
Structure validation
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