3ES9
 
 | | NADPH-Cytochrome P450 Reductase in an Open Conformation | | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Hamdane, D, Xia, C, Im, S.-C, Zhang, H, Kim, J.-J, Waskell, L. | | 登録日 | 2008-10-05 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450
J.Biol.Chem., 284, 2009
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8B02
 | | Crystal structure of the dsRBD domain of tRNA-dihydrouridine(20) synthase from Amphimedon queenslandica | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, DRBM domain-containing protein, ... | | 著者 | Pecqueur, L, Faivre, B, Hamdane, D. | | 登録日 | 2022-09-07 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.676 Å) | | 主引用文献 | Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family.
Biomolecules, 12, 2022
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6EI9
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6EI8
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4WFS
 | | Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain | | 分子名称: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, SULFATE ION, ... | | 著者 | Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D. | | 登録日 | 2014-09-17 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
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4WFT
 | | Crystal structure of tRNA-dihydrouridine(20) synthase dsRBD domain | | 分子名称: | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like | | 著者 | Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D. | | 登録日 | 2014-09-17 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
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6EZA
 | | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K mutant | | 分子名称: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | | 著者 | Bou-Nader, C, Bregeon, D, Pecqueur, L, Vincent, G, Fontecave, M, Hamdane, D. | | 登録日 | 2017-11-14 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
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6EZB
 | | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant | | 分子名称: | FLAVIN MONONUCLEOTIDE, GLYCEROL, SULFATE ION, ... | | 著者 | Bou-Nader, C, Bregeon, D, Pecqueur, L, Fontecave, M, Hamdane, D. | | 登録日 | 2017-11-14 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
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6EZC
 | | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K Q305K double mutant | | 分子名称: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | | 著者 | Bou-Nader, C, Bregeon, D, Vincent, G, Fontecave, M, Hamdane, D. | | 登録日 | 2017-11-14 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
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7NDZ
 | | ThyX reconstituted with N5-carbinolamine flavin | | 分子名称: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ... | | 著者 | Bou-Nader, C, Pecqueur, L, Hamdane, D. | | 登録日 | 2021-02-02 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
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7NDW
 | | ThyX-FADH2 soaked with 20 mM Formaldehyde | | 分子名称: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ... | | 著者 | Bou-Nader, C, Pecqueur, L, Hamdane, D. | | 登録日 | 2021-02-02 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
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3OJX
 | | Disulfide crosslinked cytochrome P450 reductase inactive | | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Xia, C, Hamdane, D, Shen, A, Choi, V, Kasper, C, Zhang, H, Im, S.-C, Waskell, L, Kim, J.-J.P. | | 登録日 | 2010-08-23 | | 公開日 | 2011-02-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding.
J.Biol.Chem., 286, 2011
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3OJW
 | | Disulfide crosslinked cytochrome P450 reductase inactive | | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH-cytochrome P450 reductase | | 著者 | Xia, C, Hamdane, D, Shen, A, Choi, V, Kasper, C, Zhang, H, Im, S.-C, Waskell, L, Kim, J.-J.P. | | 登録日 | 2010-08-23 | | 公開日 | 2011-02-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding.
J.Biol.Chem., 286, 2011
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5OC5
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5OC6
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5OC4
 | | Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD R361A-R362A mutant | | 分子名称: | CACODYLATE ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Bou-nader, C, Pecqueur, L, Hamdane, D. | | 登録日 | 2017-06-29 | | 公開日 | 2018-12-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
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