7ER9
 
 | | Crystal structure of human Biliverdin IX-beta reductase B with Febuxostat (TEI) | | Descriptor: | 2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERE
 | | Crystal structure of human Biliverdin IX-beta reductase B with Pyrantel Pamoate (PPA) | | Descriptor: | 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ER6
 | | Crystal structure of human Biliverdin IX-beta reductase B | | Descriptor: | Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ER7
 | | Crystal structure of hyman Biliverdin IX-beta reductase B with Tamibarotene (A80) | | Descriptor: | 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERC
 | | Crystal structure of human Biliverdin IX-beta reductase B with Deferasirox (ICL) | | Descriptor: | 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERD
 | | Crystal structure of human Biliverdin IX-beta reductase B with Flunixin Meglumin (FMG) | | Descriptor: | 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ER8
 | | Crystal structure of human Biliverdin IX-beta reductase B with Sulfasalazine (SAS) | | Descriptor: | 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERB
 | | Crystal structure of human Biliverdin IX-beta reductase B with Ataluren (PTC) | | Descriptor: | 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERA
 | | Crystal structure of human Biliverdin IX-beta reductase B with Olsalazine Sodium (OSS) | | Descriptor: | 5-[(E)-(3-carboxy-4-oxidanyl-phenyl)diazenyl]-2-oxidanyl-benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | Deposit date: | 2021-05-06 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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6V5D
 | | EROS3 RDC and NOE Derived Ubiquitin Ensemble | | Descriptor: | Ubiquitin | | Authors: | Lange, O.F, Lakomek, N.A, Smith, C.A, Griesinger, C, de Groot, B.L. | | Deposit date: | 2019-12-04 | | Release date: | 2020-01-01 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Enhancing NMR derived ensembles with kinetics on multiple timescales.
J.Biomol.Nmr, 74, 2020
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4UN2
 | | Crystal structure of the UBA domain of Dsk2 in complex with Ubiquitin | | Descriptor: | UBIQUITIN, UBIQUITIN DOMAIN-CONTAINING PROTEIN DSK2 | | Authors: | Michielssens, S, Peters, J.H, Ban, D, Pratihar, S, Seeliger, D, Sharma, M, Giller, K, Sabo, T.M, Becker, S, Lee, D, Griesinger, C, de Groot, B.L. | | Deposit date: | 2014-05-23 | | Release date: | 2014-08-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | A Designed Conformational Shift to Control Protein Binding Specificity.
Angew.Chem.Int.Ed.Engl., 53, 2014
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5JDP
 | | E73V mutant of the human voltage-dependent anion channel | | Descriptor: | Voltage-dependent anion-selective channel protein 1 | | Authors: | Jaremko, M, Jaremko, L, Villinger, S, Schmidt, C, Giller, K, Griesinger, C, Becker, S, Zweckstetter, M. | | Deposit date: | 2016-04-17 | | Release date: | 2016-08-10 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins.
Angew.Chem.Int.Ed.Engl., 55, 2016
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1TKQ
 | | SOLUTION STRUCTURE OF A LINKED UNSYMMETRIC GRAMICIDIN IN A MEMBRANE-ISOELECTRICAL SOLVENTS MIXTURE IN THE PRESENCE OF CsCl | | Descriptor: | GRAMICIDIN A, MINI-GRAMICIDIN A, SUCCINIC ACID | | Authors: | Xie, X, Al-Momani, L, Bockelmann, D, Griesinger, C, Koert, U. | | Deposit date: | 2004-06-09 | | Release date: | 2004-07-13 | | Last modified: | 2019-09-25 | | Method: | SOLUTION NMR | | Cite: | An Asymmetric Ion Channel Derived from Gramicidin A. Synthesis, Function and NMR Structure.
FEBS J., 272, 2005
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2KV7
 | | NMR solution structure of a soluble PrgI mutant from Salmonella Typhimurium | | Descriptor: | Protein prgI | | Authors: | Schmidt, H, Poyraz, O, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinski, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M. | | Deposit date: | 2010-03-09 | | Release date: | 2010-06-16 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Protein refolding is required for assembly of the type three secretion needle.
Nat.Struct.Mol.Biol., 17, 2010
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2L8I
 | | A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex | | Descriptor: | DNA (5'-D(*CP*GP*AP*CP*G*(2L8)P*TP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*AP*AP*AP*CP*GP*TP*CP*G)-3') | | Authors: | El-Sagheer, A, Brown, T, Ernsting, N, Dehmel, L, Griesinger, C, Mugge, C. | | Deposit date: | 2011-01-13 | | Release date: | 2011-12-28 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained.
Chemistry, 17, 2011
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2LPZ
 | | Atomic model of the Type-III Secretion System Needle | | Descriptor: | Protein prgI | | Authors: | Loquet, A, Sgourakis, N.G, Gupta, R, Giller, K, Riedel, D, Goosmann, C, Griesinger, C, Kolbe, M.G, Baker, D, Becker, S, Lange, A. | | Deposit date: | 2012-02-21 | | Release date: | 2012-05-16 | | Last modified: | 2024-05-15 | | Method: | SOLID-STATE NMR | | Cite: | Atomic model of the type III secretion system needle.
Nature, 486, 2012
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6GEL
 | | The structure of TWITCH-2B | | Descriptor: | CALCIUM ION, FORMIC ACID, GLYCEROL, ... | | Authors: | Trigo Mourino, P, Paulat, M, Thestrup, T, Griesbeck, O, Griesinger, C, Becker, S. | | Deposit date: | 2018-04-26 | | Release date: | 2019-08-21 | | Last modified: | 2019-09-11 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Dynamic tuning of FRET in a green fluorescent protein biosensor.
Sci Adv, 5, 2019
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6GEZ
 | | THE STRUCTURE OF TWITCH-2B N532F | | Descriptor: | CALCIUM ION, FORMIC ACID, Green fluorescent protein,Optimized Ratiometric Calcium Sensor,Green fluorescent protein,Green fluorescent protein | | Authors: | Trigo Mourino, P, Paulat, M, Thestrup, T, Griesbeck, O, Griesinger, C, Becker, S. | | Deposit date: | 2018-04-27 | | Release date: | 2019-08-21 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Dynamic tuning of FRET in a green fluorescent protein biosensor.
Sci Adv, 5, 2019
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1XA8
 | | Crystal Structure Analysis of Glutathione-dependent formaldehyde-activating enzyme (Gfa) | | Descriptor: | GLUTATHIONE, GLYCEROL, Glutathione-dependent formaldehyde-activating enzyme, ... | | Authors: | Neculai, A.M, Neculai, D, Griesinger, C, Vorholt, J.A, Becker, S. | | Deposit date: | 2004-08-25 | | Release date: | 2004-11-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A dynamic zinc redox switch
J.Biol.Chem., 280, 2005
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5ABS
 | | CRYSTAL STRUCTURE OF THE C-TERMINAL COILED-COIL DOMAIN OF CIN85 IN SPACE GROUP P321 | | Descriptor: | SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1, ZINC ION | | Authors: | Wong, L, Habeck, M, Griesinger, C, Becker, S. | | Deposit date: | 2015-08-07 | | Release date: | 2016-07-13 | | Last modified: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | The Adaptor Protein Cin85 Assembles Intracellular Signaling Clusters for B Cell Activation.
Sci.Signal., 9, 2016
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1KQE
 | | Solution structure of a linked shortened gramicidin A in benzene/acetone 10:1 | | Descriptor: | MINI-GRAMICIDIN A | | Authors: | Arndt, H.D, Bockelmann, D, Knoll, A, Lamberth, S, Griesinger, C, Koert, U. | | Deposit date: | 2002-01-05 | | Release date: | 2002-11-27 | | Last modified: | 2023-11-15 | | Method: | SOLUTION NMR | | Cite: | Cation Control in Functional Helical Programming: Structures of a D,L-Peptide Ion Channel
Angew.Chem.Int.Ed.Engl., 41, 2002
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8OWJ
 | | Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2 | | Descriptor: | Amyloid-beta A4 protein | | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | | Deposit date: | 2023-04-28 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
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8OVM
 | | Lipidic amyloid-beta(1-40) fibril - polymorph L2 | | Descriptor: | Amyloid-beta A4 protein | | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | | Deposit date: | 2023-04-26 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
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8OWE
 | | Lipidic amyloid-beta(1-40) fibril - polymorph L2-L3 | | Descriptor: | Amyloid-beta A4 protein | | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | | Deposit date: | 2023-04-27 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
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8OVK
 | | Lipidic amyloid-beta(1-40) fibril - polymorph L1 | | Descriptor: | Amyloid-beta A4 protein | | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | | Deposit date: | 2023-04-26 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
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