2UXA
| Crystal structure of the GluR2-flip ligand binding domain, r/g unedited. | 分子名称: | GLUTAMATE RECEPTOR SUBUNIT GLUR2-FLIP, GLUTAMIC ACID, ZINC ION | 著者 | Greger, I.H, Akamine, P, Khatri, L, Ziff, E.B. | 登録日 | 2007-03-27 | 公開日 | 2007-04-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Developmentally Regulated, Combinatorial RNA Processing Modulates Ampa Receptor Biogenesis. Neuron, 51, 2006
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3P3W
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7QHB
| Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... | 著者 | Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. | 登録日 | 2021-12-11 | 公開日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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7QHH
| Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... | 著者 | Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. | 登録日 | 2021-12-12 | 公開日 | 2022-02-23 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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3HSY
| High resolution structure of a dimeric GluR2 N-terminal domain (NTD) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2, SULFATE ION, ... | 著者 | Rossmann, M, Sukumaran, M, Penn, A.C, Veprintsev, D.B, Greger, I.H. | 登録日 | 2009-06-11 | 公開日 | 2010-06-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers Embo J., 30, 2011
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4GPA
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8AYM
| Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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8AYN
| Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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8AYO
| Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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3N6V
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3O21
| High resolution structure of GluA3 N-terminal domain (NTD) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 3, PHOSPHATE ION | 著者 | Rossmann, M, Sukumaran, M, Penn, A.C, Veprintsev, D.B, Babu, M.M, Jensen, M.H, Greger, I.H. | 登録日 | 2010-07-22 | 公開日 | 2011-03-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | Dynamics and allosteric potential of the AMPA receptor N-terminal domain Embo J., 30, 2011
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3O2J
| Structure of the GluA2 NTD-dimer interface mutant, N54A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | 著者 | Rossmann, M, Sukumaran, M, Penn, A.C, Veprintsev, D.B, Greger, I.H. | 登録日 | 2010-07-22 | 公開日 | 2011-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers Embo J., 30, 2011
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5FWX
| Crystal structure of the AMPA receptor GluA2/A4 N-terminal domain heterodimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMATE RECEPTOR 2, GLUTAMATE RECEPTOR 4, ... | 著者 | Garcia-Nafria, J, Herguedas, B, Greger, I.H. | 登録日 | 2016-02-21 | 公開日 | 2016-03-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and Organization of Heteromeric Ampa-Type Glutamate Receptors. Science, 352, 2016
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5IDE
| Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I) | 分子名称: | Glutamate receptor 2, Glutamate receptor 3 | 著者 | Herguedas, B, Garcia-Nafria, J, Fernandez-Leiro, R, Greger, I.H. | 登録日 | 2016-02-24 | 公開日 | 2016-03-16 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8.25 Å) | 主引用文献 | Structure and organization of heteromeric AMPA-type glutamate receptors. Science, 352, 2016
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5FWY
| Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMATE RECEPTOR 2, GLUTAMATE RECEPTOR 3, ... | 著者 | Herguedas, B, Garcia-Nafria, J, Greger, I.H. | 登録日 | 2016-02-21 | 公開日 | 2016-03-16 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structure and Organization of Heteromeric Ampa-Type Glutamate Receptors. Science, 352, 2016
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5IDF
| Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model II) | 分子名称: | Glutamate receptor 2, Glutamate receptor 3 | 著者 | Herguedas, B, Garcia-Nafria, J, Fernandez-Leiro, R, Greger, I.H. | 登録日 | 2016-02-24 | 公開日 | 2016-03-16 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (10.31 Å) | 主引用文献 | Structure and organization of heteromeric AMPA-type glutamate receptors. Science, 352, 2016
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9B60
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9B5Z
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9B64
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9B67
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9B6A
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9B63
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9B61
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9B69
| GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | 著者 | Nakagawa, T, Greger, I.H. | 登録日 | 2024-03-23 | 公開日 | 2024-07-31 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | 主引用文献 | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 31, 2024
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9B68
| GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | 著者 | Nakagawa, T, Greger, I.H. | 登録日 | 2024-03-23 | 公開日 | 2024-07-31 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 31, 2024
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