7LGW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lgw by Molmil](/molmil-images/mine/7lgw) | |
7LH2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lh2 by Molmil](/molmil-images/mine/7lh2) | |
7LH3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lh3 by Molmil](/molmil-images/mine/7lh3) | |
1N0T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n0t by Molmil](/molmil-images/mine/1n0t) | X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution. | 分子名称: | (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, ACETATE ION, Glutamate receptor 2, ... | 著者 | Hogner, A, Greenwood, J.R, Liljefors, T, Lunn, M.-L, Egebjerg, J, Larsen, I.K, Gouaux, E, Kastrup, J.S. | 登録日 | 2002-10-15 | 公開日 | 2003-03-04 | 最終更新日 | 2017-08-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Competitive antagonism of AMPA receptors by ligands of
different classes: crystal structure of ATPO bound to the
GluR2 ligand-binding core, in comparison with DNQX. J.Med.Chem., 46, 2003
|
|
5I74
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i74 by Molmil](/molmil-images/mine/5i74) | X-ray structure of the ts3 human serotonin transporter complexed with Br-citalopram at the central site | 分子名称: | (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, ... | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | 登録日 | 2016-02-16 | 公開日 | 2016-04-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.395 Å) | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
|
|
5I71
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i71 by Molmil](/molmil-images/mine/5i71) | X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site | 分子名称: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, ... | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | 登録日 | 2016-02-16 | 公開日 | 2016-04-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
|
|
5IOU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5iou by Molmil](/molmil-images/mine/5iou) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation | 分子名称: | GLUTAMIC ACID, GLYCINE, Ionotropic glutamate receptor subunit NR2B, ... | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
5IPU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ipu by Molmil](/molmil-images/mine/5ipu) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (15.4 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
5IPS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ips by Molmil](/molmil-images/mine/5ips) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 4 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (13.5 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
5I6Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i6z by Molmil](/molmil-images/mine/5i6z) | X-ray structure of the ts2 human serotonin transporter | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | 登録日 | 2016-02-16 | 公開日 | 2016-04-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.53 Å) | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
|
|
5I73
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i73 by Molmil](/molmil-images/mine/5i73) | X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central and allosteric sites | 分子名称: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINOHEXANOIC ACID, ... | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | 登録日 | 2016-02-16 | 公開日 | 2016-04-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
|
|
5IOV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5iov by Molmil](/molmil-images/mine/5iov) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine/Ro25-6981-bound conformation | 分子名称: | 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, GLUTAMIC ACID, GLYCINE, ... | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
5IPV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ipv by Molmil](/molmil-images/mine/5ipv) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 1 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, McHaourab, S.H, Gouaux, E. | 登録日 | 2016-03-10 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (9.25 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
5I66
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i66 by Molmil](/molmil-images/mine/5i66) | X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter | 分子名称: | 8B6 antibody, heavy chain, light chain | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | 登録日 | 2016-02-16 | 公開日 | 2016-04-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.624 Å) | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
|
|
5I75
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i75 by Molmil](/molmil-images/mine/5i75) | X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site and Br-citalopram at the allosteric site | 分子名称: | (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile, (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | 登録日 | 2016-02-16 | 公開日 | 2016-04-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
|
|
5I6X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i6x by Molmil](/molmil-images/mine/5i6x) | X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | 登録日 | 2016-02-16 | 公開日 | 2016-04-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
|
|
5IPT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ipt by Molmil](/molmil-images/mine/5ipt) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 5 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (14.1 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
5IPR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ipr by Molmil](/molmil-images/mine/5ipr) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 3 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (14.1 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
5IPQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ipq by Molmil](/molmil-images/mine/5ipq) | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 2 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (13.5 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
|
|
4MM5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mm5 by Molmil](/molmil-images/mine/4mm5) | Crystal structure of LeuBAT (delta13 mutant) in complex with sertraline | 分子名称: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter | 著者 | Wang, H, Gouaux, E. | 登録日 | 2013-09-08 | 公開日 | 2013-10-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
|
|
4MMB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mmb by Molmil](/molmil-images/mine/4mmb) | Crystal structure of LeuBAT (delta6 mutant) in complex with sertraline | 分子名称: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter, ... | 著者 | Wang, H, Gouaux, E. | 登録日 | 2013-09-08 | 公開日 | 2013-10-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
|
|
4MMA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mma by Molmil](/molmil-images/mine/4mma) | |
1MQD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mqd by Molmil](/molmil-images/mine/1mqd) | X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. | 分子名称: | (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, GLYCEROL, Glutamate receptor subunit 2, ... | 著者 | Kasper, C, Lunn, M.-L, Liljefors, T, Gouaux, E, Egebjerg, J, Kastrup, J.S. | 登録日 | 2002-09-16 | 公開日 | 2003-07-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | GluR2 ligand-binding core complexes: Importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists. FEBS Lett., 531, 2002
|
|
4MM6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mm6 by Molmil](/molmil-images/mine/4mm6) | |
4MME
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mme by Molmil](/molmil-images/mine/4mme) | Crystal structure of LeuBAT (delta6 mutant) in complex with mazindol | 分子名称: | (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ... | 著者 | Wang, H, Gouaux, E. | 登録日 | 2013-09-08 | 公開日 | 2013-10-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
|
|