1C5G
| PLASMINOGEN ACTIVATOR INHIBITOR-1 | 分子名称: | PLASMINOGEN ACTIVATOR INHIBITOR-1 | 著者 | Goldsmith, E.J. | 登録日 | 1999-12-07 | 公開日 | 1999-12-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition. Nat.Struct.Biol., 2, 1995
|
|
8EDH
| |
1GOL
| |
6OTS
| Rat ERK2 E320K | 分子名称: | Mitogen-activated protein kinase 1 | 著者 | Taylor, C.A, Cormier, K.W, Juang, Y.-C, Goldsmith, E.J, Cobb, M.H. | 登録日 | 2019-05-03 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional divergence caused by mutations in an energetic hotspot in ERK2. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
5W7T
| |
7UOS
| |
2NVA
| The X-ray crystal structure of the Paramecium bursaria Chlorella virus arginine decarboxylase bound to agmatine | 分子名称: | (4-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, arginine decarboxylase, A207R protein | 著者 | Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A. | 登録日 | 2006-11-11 | 公開日 | 2007-03-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity. Biochemistry, 46, 2007
|
|
2NV9
| The X-ray Crystal Structure of the Paramecium bursaria Chlorella virus arginine decarboxylase | 分子名称: | A207R protein, arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A. | 登録日 | 2006-11-11 | 公開日 | 2007-03-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity. Biochemistry, 46, 2007
|
|
6OT6
| Rat ERK2 D319N | 分子名称: | Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Taylor, C.A, Goldsmith, E.J, Cobb, M.H. | 登録日 | 2019-05-02 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Functional divergence caused by mutations in an energetic hotspot in ERK2. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
5D9H
| Crystal structure of SPAK (STK39) dimer in the basal activity state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, STE20/SPS1-related proline-alanine-rich protein kinase, ... | 著者 | Taylor, C.A, Juang, Y.C, Goldsmith, E.J, Cobb, M.H. | 登録日 | 2015-08-18 | 公開日 | 2015-09-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK. Biochemistry, 54, 2015
|
|
4PWN
| Crystal structure of Active WNK1 kinase | 分子名称: | PHOSPHATE ION, Serine/threonine-protein kinase WNK1 | 著者 | Piala, A, Moon, T, Akella, T, He, H, Cobbm, M.H, Goldsmith, E. | 登録日 | 2014-03-20 | 公開日 | 2014-05-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation. Sci.Signal., 7, 2014
|
|
4Q2A
| WNK1: A chloride sensor via autophosphorylation | 分子名称: | BROMIDE ION, Serine/threonine-protein kinase WNK1 | 著者 | Piala, A, Moon, T, Akella, R, He, H, Cobb, M.H, Goldsmith, E. | 登録日 | 2014-04-07 | 公開日 | 2014-05-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation. Sci.Signal., 7, 2014
|
|
2PLK
| |
5UMO
| |
6OL2
| Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening | 分子名称: | ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ... | 著者 | Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J. | 登録日 | 2019-04-15 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening To Be Published
|
|
1F3T
| CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE (ODC) COMPLEXED WITH PUTRESCINE, ODC'S REACTION PRODUCT. | 分子名称: | 1,4-DIAMINOBUTANE, ORNITHINE DECARBOXYLASE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Jackson, L.K, Brooks, H.B, Osterman, A.L, Goldsmith, E.J, Phillips, M.A. | 登録日 | 2000-06-06 | 公開日 | 2000-11-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Altering the reaction specificity of eukaryotic ornithine decarboxylase. Biochemistry, 39, 2000
|
|
2PLJ
| |
2TOD
| ORNITHINE DECARBOXYLASE FROM TRYPANOSOMA BRUCEI K69A MUTANT IN COMPLEX WITH ALPHA-DIFLUOROMETHYLORNITHINE | 分子名称: | ALPHA-DIFLUOROMETHYLORNITHINE, PROTEIN (ORNITHINE DECARBOXYLASE), PYRIDOXAL-5'-PHOSPHATE | 著者 | Grishin, N.V, Osterman, A.L, Brooks, H.B, Phillips, M.A, Goldsmith, E.J. | 登録日 | 1999-05-18 | 公開日 | 1999-11-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine. Biochemistry, 38, 1999
|
|
5UOJ
| |
2LRU
| Solution Structure of the WNK1 Autoinhibitory Domain | 分子名称: | Serine/threonine-protein kinase WNK1 | 著者 | Moon, T.M, Correa, F, Gardner, K.H, Goldsmith, E.J. | 登録日 | 2012-04-13 | 公開日 | 2012-05-23 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain. J.Mol.Biol., 425, 2013
|
|
6CN9
| |
1A9U
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580 | 分子名称: | 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, MAP KINASE P38 | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-04-10 | 公開日 | 1999-04-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
|
|
1BMK
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655 | 分子名称: | 4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE, PROTEIN (MAP KINASE P38) | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-23 | 公開日 | 1999-07-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
|
|
1BL6
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995 | 分子名称: | 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38) | 著者 | Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-11 | 公開日 | 1999-07-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
|
|
1BL7
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025 | 分子名称: | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38) | 著者 | Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-23 | 公開日 | 1999-07-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
|
|