6ME5
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![BU of 6me5 by Molmil](/molmil-images/mine/6me5) | XFEL crystal structure of human melatonin receptor MT1 in complex with agomelatine | Descriptor: | OLEIC ACID, chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, ~{N}-[2-(7-methoxynaphthalen-1-yl)ethyl]ethanamide | Authors: | Stauch, B, Johansson, L.C, McCorvy, J.D, Patel, N, Han, G.W, Gati, C, Batyuk, A, Ishchenko, A, Brehm, W, White, T.A, Michaelian, N, Madsen, C, Zhu, L, Grant, T.D, Grandner, J.M, Olsen, R.H.J, Tribo, A.R, Weierstall, U, Roth, B.L, Katritch, V, Liu, W, Cherezov, V. | Deposit date: | 2018-09-05 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569, 2019
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6ME8
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![BU of 6me8 by Molmil](/molmil-images/mine/6me8) | XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin | Descriptor: | N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, ZINC ION | Authors: | Johansson, L.C, Stauch, B, McCorvy, J, Han, G.W, Patel, N, Batyuk, A, Gati, C, Li, C, Grandner, J, Hao, S, Olsen, R.H.J, Tribo, A.R, Zaare, S, Zhu, L, Zatsepin, N.A, Weierstall, U, Liu, W, Roth, B.L, Katritch, V, Cherezov, V. | Deposit date: | 2018-09-05 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity. Nature, 569, 2019
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6M9T
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![BU of 6m9t by Molmil](/molmil-images/mine/6m9t) | Crystal structure of EP3 receptor bound to misoprostol-FA | Descriptor: | (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, OLEIC ACID, ... | Authors: | Audet, M, White, K.L, Breton, B, Zarzycka, B, Han, G.W, Lu, Y, Gati, C, Batyuk, A, Popov, P, Velasquez, J, Manahan, D, Hu, H, Weierstall, U, Liu, W, Shui, W, Katrich, V, Cherezov, V, Hanson, M.A, Stevens, R.C. | Deposit date: | 2018-08-24 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor. Nat. Chem. Biol., 15, 2019
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6UO8
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![BU of 6uo8 by Molmil](/molmil-images/mine/6uo8) | Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator GS39783 | Descriptor: | (R)-(3-aminopropyl)methylphosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shaye, H, Han, G.W, Gati, C, Cherezov, V. | Deposit date: | 2019-10-14 | Release date: | 2020-06-10 | Last modified: | 2020-08-26 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Structural basis of the activation of a metabotropic GABA receptor. Nature, 584, 2020
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6UO9
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![BU of 6uo9 by Molmil](/molmil-images/mine/6uo9) | Human metabotropic GABA(B) receptor bound to agonist SKF97541 in its intermediate state 2 | Descriptor: | (R)-(3-aminopropyl)methylphosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shaye, H, Han, G.W, Gati, C, Cherezov, V. | Deposit date: | 2019-10-14 | Release date: | 2020-06-10 | Last modified: | 2020-08-26 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structural basis of the activation of a metabotropic GABA receptor. Nature, 584, 2020
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6UOA
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![BU of 6uoa by Molmil](/molmil-images/mine/6uoa) | Human metabotropic GABA(B) receptor in its intermediate state 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ... | Authors: | Shaye, H, Han, G.W, Gati, C, Cherezov, V. | Deposit date: | 2019-10-14 | Release date: | 2020-06-10 | Last modified: | 2020-08-26 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | Structural basis of the activation of a metabotropic GABA receptor. Nature, 584, 2020
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6WQA
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![BU of 6wqa by Molmil](/molmil-images/mine/6wqa) | 2.0A angstrom A2a adenosine receptor structure using XFEL data collected in helium atmosphere. | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | Authors: | Lee, M.-Y, Geiger, J, Ishchenko, A, Han, G.W, Barty, A, White, T.A, Gati, C, Batyuk, A, Hunter, M.S, Aquila, A, Boutet, S, Weierstall, U, Cherezov, V, Liu, W. | Deposit date: | 2020-04-28 | Release date: | 2020-11-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase Iucrj, 7, 2020
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6WW2
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![BU of 6ww2 by Molmil](/molmil-images/mine/6ww2) | Structure of human Frizzled5 by fiducial-assisted cryo-EM | Descriptor: | Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | Authors: | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | Deposit date: | 2020-05-07 | Release date: | 2020-08-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife, 9, 2020
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6VJM
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![BU of 6vjm by Molmil](/molmil-images/mine/6vjm) | Human metabotropic GABA(B) receptor in its apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shaye, H, Han, G.W, Gati, C, Cherezov, V. | Deposit date: | 2020-01-16 | Release date: | 2020-06-10 | Last modified: | 2020-08-26 | Method: | ELECTRON MICROSCOPY (3.97 Å) | Cite: | Structural basis of the activation of a metabotropic GABA receptor. Nature, 584, 2020
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