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PDB: 79 results

1ZJK
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BU of 1zjk by Molmil
Crystal structure of the zymogen catalytic region of human MASP-2
Descriptor: Mannan-binding lectin serine protease 2
Authors:Gal, P, Harmat, V, Kocsis, A, Bian, T, Barna, L, Ambrus, G, Vegh, B, Balczer, J, Sim, R.B, Naray-Szabo, G, Zavodszky, P.
Deposit date:2005-04-29
Release date:2005-07-26
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations
J.Biol.Chem., 280, 2005
4UEE
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BU of 4uee by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH
Descriptor: (2S)-2-{[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-17
Release date:2016-01-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
4UEZ
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BU of 4uez by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH
Descriptor: (2S)-3-[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]-2-phenylethyl}(hydroxy)phosphoryl]-2-benzylpropanoic acid, HUMAN CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-22
Release date:2016-01-20
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
6FZB
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BU of 6fzb by Molmil
AadA in complex with ATP, magnesium and streptomycin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kanchugal P, S, Selmer, M.
Deposit date:2018-03-14
Release date:2018-06-13
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase fromSalmonella enterica.
J. Biol. Chem., 293, 2018
6XZ0
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BU of 6xz0 by Molmil
Crystal structure of spectinomycin adenyltransferase AAD(9) from Enterococcus faecialis with spectinomycin
Descriptor: SPECTINOMYCIN, Streptomycin 3''-adenylyltransferase
Authors:Kanchugal P, S, Selmer, M.
Deposit date:2020-01-31
Release date:2020-04-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis.
Antimicrob.Agents Chemother., 64, 2020
7QCU
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BU of 7qcu by Molmil
Structure of the MUCIN-2 Cterminal domains partially deglycosylated.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-2, ...
Authors:Gallego, P, Hansson, G.C.
Deposit date:2021-11-25
Release date:2023-03-08
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Nat Commun, 14, 2023
7QCN
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BU of 7qcn by Molmil
Structure of the MUCIN-2 Cterminal domains: vWCN to TIL domains with a C2 symmetry
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-2, ...
Authors:Gallego, P, Hansson, G.C.
Deposit date:2021-11-24
Release date:2023-03-08
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Nat Commun, 14, 2023
7QCL
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BU of 7qcl by Molmil
Structure of the MUCIN-2 Cterminal domains
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-2, ...
Authors:Gallego, P, Hansson, G.C.
Deposit date:2021-11-24
Release date:2023-03-08
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Nat Commun, 14, 2023
6XXQ
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BU of 6xxq by Molmil
Crystal structure of spectinomycin adenyltransferase AAD(9) from Enterococcus faecialis with ATP and spectinomycin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ...
Authors:Kanchugal P, S, Selmer, M.
Deposit date:2020-01-28
Release date:2020-04-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis.
Antimicrob.Agents Chemother., 64, 2020
6I6Z
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BU of 6i6z by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH
Descriptor: (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, Carboxypeptidase A1, ZINC ION
Authors:Gallego, P, Reverter, D.
Deposit date:2018-11-15
Release date:2018-12-12
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes.
J. Med. Chem., 62, 2019
5FW6
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BU of 5fw6 by Molmil
Structure of human transthyretin mutant A108V
Descriptor: TRANSTHYRETIN
Authors:Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
Deposit date:2016-02-12
Release date:2017-03-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
5FW8
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BU of 5fw8 by Molmil
Structure of human transthyretin mutant E89K
Descriptor: TRANSTHYRETIN
Authors:Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
Deposit date:2016-02-12
Release date:2016-12-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published
5AEK
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BU of 5aek by Molmil
Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W
Descriptor: SENTRIN-SPECIFIC PROTEASE 2, SMALL UBIQUITIN-RELATED MODIFIER 1
Authors:Gallego, P, Grana-Montes, R, Espargaro, A, Castillo, V, Torrent, J, Lange, R, Papaleo, E, Lindorff-Larsend, K, Ventura, S, Reverter, D.
Deposit date:2014-12-23
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Stepping Back and Forward on Sumo Folding Evolution
To be Published
5AQ0
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BU of 5aq0 by Molmil
The structure of the Transthyretin-like domain of the first catalytic domain of the HUMAN Carboxypeptidase D
Descriptor: CARBOXYPEPTIDASE D, GLYCEROL
Authors:Gallego, P, Garcia-Pardo, J, Lorenzo, J, Aviles, F.X, Ventura, S, Reverter, D.
Deposit date:2015-09-18
Release date:2016-09-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:The Structure of the Ttldomain of the Human Carboxypeptidase D
To be Published
5LQG
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BU of 5lqg by Molmil
A two-quartet G-quadruplex formed by human telomere in KCl solution at neutral pH
Descriptor: DNA (5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*G)-3')
Authors:Galer, P, Wang, B, Sket, P, Plavec, J.
Deposit date:2016-08-17
Release date:2018-06-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Reversible pH Switch of Two-Quartet G-Quadruplexes Formed by Human Telomere.
Angew.Chem.Int.Ed.Engl., 55, 2016
5OM9
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BU of 5om9 by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor
Descriptor: (2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic acid, Carboxypeptidase A1, ZINC ION
Authors:Gallego, P, Granados, C, Fernandez, D, Pallares, I, Covaleda, G, Aviles, F.X, Vendrell, J, Reverter, D.
Deposit date:2017-07-28
Release date:2017-08-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.
ACS Med Chem Lett, 8, 2017
5LQH
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BU of 5lqh by Molmil
A two-quartet G-quadruplex formed by human telomere in KCl solution at pH 5.0
Descriptor: DNA (5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*G)-3')
Authors:Galer, P, Wang, B, Sket, P, Plavec, J.
Deposit date:2016-08-17
Release date:2018-01-17
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Reversible pH Switch of Two-Quartet G-Quadruplexes Formed by Human Telomere.
Angew.Chem.Int.Ed.Engl., 55, 2016
6SXJ
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BU of 6sxj by Molmil
Crystal structure of spectinomycin adenyltransferase AAD(9) from Enterococcus faecialis
Descriptor: GLYCEROL, Streptomycin 3''-adenylyltransferase
Authors:Kanchugal P, S, Selmer, M.
Deposit date:2019-09-26
Release date:2020-04-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis.
Antimicrob.Agents Chemother., 64, 2020
3NS7
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BU of 3ns7 by Molmil
Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1)
Descriptor: (3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid, Caspase-1
Authors:Galatsis, P.
Deposit date:2010-07-01
Release date:2011-08-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).
Bioorg.Med.Chem.Lett., 20, 2010
3OWU
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BU of 3owu by Molmil
Crystal Structure of Ketosteroid Isomerase D40N/C69S/C81S/C97S/F86C-CN from P. putida with Bound Equilenin
Descriptor: EQUILENIN, Steroid Delta-isomerase
Authors:Sigala, P.A, Fenn, T.D, Herschlag, D.
Deposit date:2010-09-20
Release date:2011-09-21
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.
Proc.Natl.Acad.Sci.USA, 109, 2012
3OX9
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BU of 3ox9 by Molmil
Crystal Structure of Ketosteroid Isomerase D40N/C69S/C81S/C97S/F86C-CN from P. putida
Descriptor: Steroid Delta-isomerase
Authors:Sigala, P.A, Fenn, T.D, Herschlag, D.
Deposit date:2010-09-21
Release date:2011-09-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.
Proc.Natl.Acad.Sci.USA, 109, 2012
3OWS
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BU of 3ows by Molmil
Crystal Structure of Ketosteroid Isomerase D40N/C69S/C81S/C97S/M116C-CN from P. putida with Bound Equilenin
Descriptor: EQUILENIN, Steroid Delta-isomerase
Authors:Sigala, P.A, Fenn, T.D, Herschlag, D.
Deposit date:2010-09-20
Release date:2011-09-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.
Proc.Natl.Acad.Sci.USA, 109, 2013
3OXA
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BU of 3oxa by Molmil
Crystal Structure of Ketosteroid Isomerase D40N/C69S/C81S/C97S/M116C-CN from P. putida
Descriptor: Steroid Delta-isomerase
Authors:Sigala, P.A, Fenn, T.D, Herschlag, D.
Deposit date:2010-09-21
Release date:2011-09-21
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.
Proc.Natl.Acad.Sci.USA, 109, 2012
3OWY
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BU of 3owy by Molmil
Crystal Structure of Ketosteroid Isomerase D40N/C69S/C81S/C97S/M105C-CN from P. putida with Bound Equilenin
Descriptor: EQUILENIN, Steroid Delta-isomerase
Authors:Sigala, P.A, Fenn, T.D, Herschlag, D.
Deposit date:2010-09-20
Release date:2011-09-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.
Proc.Natl.Acad.Sci.USA, 109, 2012
3ZKE
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BU of 3zke by Molmil
Structure of LC8 in complex with Nek9 peptide
Descriptor: DYNEIN LIGHT CHAIN 1, CYTOPLASMIC, NEK9 PROTEIN
Authors:Gallego, P, Velazquez-Campoy, A, Regue, L, Roig, J, Reverter, D.
Deposit date:2013-01-22
Release date:2013-03-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of the Regulation of the Dynll/Lc8 Binding to Nek9 by Phosphorylation
J.Biol.Chem., 288, 2013

 

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