5V1I
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![BU of 5v1i by Molmil](/molmil-images/mine/5v1i) | DNA polymerase beta ternary product complex with 8-oxoG:C and inserted dCTP | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(8OG)P*C)-3'), ... | 著者 | Freudenthal, B.D, Smith, M.R, Whitaker, A.M, Schaich, M.A. | 登録日 | 2017-03-02 | 公開日 | 2017-05-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.035 Å) | 主引用文献 | Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res., 45, 2017
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5V1R
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![BU of 5v1r by Molmil](/molmil-images/mine/5v1r) | DNA polymerase beta reactant complex with 8-oxoG:C at the primer terminus and incoming dCTP | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Freudenthal, B.D, Smith, M.R, Whitaker, A.M, Schaich, M.A. | 登録日 | 2017-03-02 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.077 Å) | 主引用文献 | Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res., 45, 2017
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5V1H
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![BU of 5v1h by Molmil](/molmil-images/mine/5v1h) | DNA polymerase beta binary complex with 8-oxoG:A at the primer terminus | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(8OG))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Freudenthal, B.D, Schaich, M.A, Whitaker, A.M, Smith, M.R. | 登録日 | 2017-03-02 | 公開日 | 2017-05-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.946 Å) | 主引用文献 | Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res., 45, 2017
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5V1O
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![BU of 5v1o by Molmil](/molmil-images/mine/5v1o) | DNA polymerase beta product complex with 8-oxoG:A and inserted dCTP | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(8OG)P*C)-3'), ... | 著者 | Freudenthal, B.D, Schaich, M.A, Whitaker, A.M, Smith, M.R. | 登録日 | 2017-03-02 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res., 45, 2017
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5V1F
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![BU of 5v1f by Molmil](/molmil-images/mine/5v1f) | DNA polymerase beta substrate complex with 8-oxoG at the primer terminus and incoming dCTP | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Freudenthal, B.D, Smith, M.R, Schaich, M.A, Whitaker, A.M. | 登録日 | 2017-03-02 | 公開日 | 2017-05-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.181 Å) | 主引用文献 | Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Res., 45, 2017
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6MR8
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![BU of 6mr8 by Molmil](/molmil-images/mine/6mr8) | D276G DNA polymerase beta substrate complex with templating adenine and incoming Fapy-dGTP analog | 分子名称: | 1,2-ETHANEDIOL, 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol, CALCIUM ION, ... | 著者 | Freudenthal, B.D, Smith, M.R, Wilson, S.H, Beard, W.A. | 登録日 | 2018-10-11 | 公開日 | 2019-01-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | 主引用文献 | A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Res., 47, 2019
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6MR7
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![BU of 6mr7 by Molmil](/molmil-images/mine/6mr7) | DNA polymerase beta substrate complex with templating adenine and incoming Fapy-dGTP analog | 分子名称: | 1,2-ETHANEDIOL, 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol, CALCIUM ION, ... | 著者 | Freudenthal, B.D, Smith, M.R, Wilson, S.H, Beard, W.A. | 登録日 | 2018-10-11 | 公開日 | 2019-01-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.144 Å) | 主引用文献 | A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Res., 47, 2019
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7TR7
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![BU of 7tr7 by Molmil](/molmil-images/mine/7tr7) | APE1 product complex with abasic ssDNA | 分子名称: | DNA (5'-D(P*(3DR)P*CP*GP*AP*TP*GP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION | 著者 | Freudenthal, B.D, Hoitsma, N.M. | 登録日 | 2022-01-28 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics. Nucleic Acids Res., 51, 2023
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7U53
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![BU of 7u53 by Molmil](/molmil-images/mine/7u53) | |
7U51
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![BU of 7u51 by Molmil](/molmil-images/mine/7u51) | |
7U52
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![BU of 7u52 by Molmil](/molmil-images/mine/7u52) | |
3L0X
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![BU of 3l0x by Molmil](/molmil-images/mine/3l0x) | |
3L0W
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![BU of 3l0w by Molmil](/molmil-images/mine/3l0w) | Structure of split monoubiquitinated PCNA with ubiquitin in position two | 分子名称: | Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen | 著者 | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | 登録日 | 2009-12-10 | 公開日 | 2010-03-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
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3L10
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![BU of 3l10 by Molmil](/molmil-images/mine/3l10) | Structure of split monoubiquitinated PCNA with ubiquitin in position one | 分子名称: | Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen | 著者 | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | 登録日 | 2009-12-10 | 公開日 | 2010-03-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
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7LPH
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![BU of 7lph by Molmil](/molmil-images/mine/7lph) | APE1 Mn-bound product complex with abasic ribonucleotide DNA | 分子名称: | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-R(P*N)-D(P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Hoitsma, N.M. | 登録日 | 2021-02-11 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker. Comput Struct Biotechnol J, 19, 2021
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7LPJ
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![BU of 7lpj by Molmil](/molmil-images/mine/7lpj) | APE1 Mn-bound phosphorothioate substrate complex with abasic ribonucleotide DNA | 分子名称: | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-R(P*(YA4))-D(P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase, ... | 著者 | Freudenthal, B.D, Hoitsma, N.M. | 登録日 | 2021-02-11 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker. Comput Struct Biotechnol J, 19, 2021
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7LPG
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![BU of 7lpg by Molmil](/molmil-images/mine/7lpg) | APE1 product complex with abasic ribonucleotide DNA | 分子名称: | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-R(P*N)-D(P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Hoitsma, N.M. | 登録日 | 2021-02-11 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker. Comput Struct Biotechnol J, 19, 2021
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7LPI
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![BU of 7lpi by Molmil](/molmil-images/mine/7lpi) | APE1 phosphorothioate substrate complex with abasic ribonucleotide DNA | 分子名称: | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-R(P*(YA4))-D(P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase | 著者 | Freudenthal, B.D, Hoitsma, N.M. | 登録日 | 2021-02-11 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker. Comput Struct Biotechnol J, 19, 2021
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5WN0
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![BU of 5wn0 by Molmil](/molmil-images/mine/5wn0) | APE1 exonuclease substrate complex with a C/G match | 分子名称: | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Whitaker, A.M. | 登録日 | 2017-07-31 | 公開日 | 2018-02-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
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6BOS
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![BU of 6bos by Molmil](/molmil-images/mine/6bos) | |
6BOU
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![BU of 6bou by Molmil](/molmil-images/mine/6bou) | |
6BOV
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![BU of 6bov by Molmil](/molmil-images/mine/6bov) | |
6BOQ
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![BU of 6boq by Molmil](/molmil-images/mine/6boq) | Human APE1 substrate complex with an A/A mismatch adjacent the THF | 分子名称: | 1,2-ETHANEDIOL, 21-mer DNA, DNA-(apurinic or apyrimidinic site) lyase | 著者 | Freudenthal, B.D, Whitaker, A.M, Fairlamb, M.S. | 登録日 | 2017-11-20 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallogr D Struct Biol, 74, 2018
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6BOR
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![BU of 6bor by Molmil](/molmil-images/mine/6bor) | Human APE1 substrate complex with an G/G mismatch adjacent the THF | 分子名称: | 1,2-ETHANEDIOL, 21-mer DNA, CHLORIDE ION, ... | 著者 | Freudenthal, B.D, Whitaker, A.M, Fairlamb, M.S. | 登録日 | 2017-11-20 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallogr D Struct Biol, 74, 2018
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6BOT
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![BU of 6bot by Molmil](/molmil-images/mine/6bot) | Human APE1 substrate complex with an C/C mismatch adjacent the THF | 分子名称: | 1,2-ETHANEDIOL, 21-mer DNA, DNA-(apurinic or apyrimidinic site) lyase | 著者 | Freudenthal, B.D, Whitaker, A.M, Fairlamb, M.S. | 登録日 | 2017-11-20 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallogr D Struct Biol, 74, 2018
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